====== 6-Thio-2-deoxyguanosine 2μM R06 exp259 ======
==== Mechanism of Action ====
Nucleoside analog, incorporated into telomeric DNA by telomerase, impairs proliferation of telomerase-positive cells
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Antimetabolite
  * **<color #00a2e8>Class / Subclass 2:</color>** DNA Damage, Repair and Replication / Helix-Distorting Adduct



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%2'-Deoxythioguanosine%%
    * **<color #00a2e8>Synonyms:</color>** 6-thio-dG; β-TGdR; 6-thio-dG;β-TGdR
    * **<color #00a2e8>CAS #:</color>** 789-61-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3000603|3000603]]
    * **<color #00a2e8>IUPAC:</color>** %%2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** SCVJRXQHFJXZFZ-KVQBGUIXSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 283.31
    * **<color #00a2e8>Canonical SMILES:</color>** C1C(C(OC1N2C=NC3=C2NC(=NC3=S)N)CO)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC(=NC3=S)N)CO)O
    * **<color #00a2e8>Molecular Formula:</color>** C10H13N5O3S
{{:chemogenomics:structures:chem-0154.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals
    * **<color #00a2e8>Catalog #:</color>** S7757
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C10H13N5O3S 284.08119; found 284.07903
</panel>


<panel title='Dose Response Curve'>
Dose response curve not available.
</panel>


</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 06
    * **<color #00a2e8>Dose</color>**: 2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.6
    * **<color #00a2e8>Numbers of reads</color>**: 8752501


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/28|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/6-Thio-2-deoxyguanosine_2uM_Round-6_exp259.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='6-Thio-2-deoxyguanosine 2μM R06 exp259'>
{{:chemogenomics:cranks_plots:exp259.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:C:CKAP5|CKAP5]]|-2.81|0.56|
|[[:human_genes:M:MAU2|MAU2]]|-2.63|0.56|
|[[:human_genes:P:PPP2CA|PPP2CA]]|-2.59|0.20|
|[[:human_genes:T:TMEM132A|TMEM132A]]|-2.56|0.20|
|[[:human_genes:R:RAPSN|RAPSN]]|-2.48|0.20|
|[[:human_genes:I:IL1RL2|IL1RL2]]|-2.43|0.20|
|[[:human_genes:M:MGA|MGA]]|-2.36|0.20|
|[[:human_genes:I:INTS6|INTS6]]|-2.34|0.56|
|[[:human_genes:C:CCNA2|CCNA2]]|-2.29|0.53|
|[[:human_genes:O:ORC1|ORC1]]|-2.28|0.53|
|[[:human_genes:S:SV2A|SV2A]]|-2.27|0.22|
|[[:human_genes:C:C12orf66|C12orf66]]|-2.27|0.22|
|[[:human_genes:C:CDT1|CDT1]]|-2.24|0.56|
|[[:human_genes:Z:ZFAND2B|ZFAND2B]]|-2.21|0.53|
|[[:human_genes:P:PRC1|PRC1]]|-2.21|0.56|
|[[:human_genes:L:LANCL2|LANCL2]]|-2.18|0.56|
|[[:human_genes:P:PPP2R1A|PPP2R1A]]|-2.15|0.53|
|[[:human_genes:S:SKIV2L2|SKIV2L2]]|-2.15|0.57|
|[[:human_genes:F:FGF10|FGF10]]|-2.08|0.56|
|[[:human_genes:W:WEE1|WEE1]]|-2.07|0.61|
|[[:human_genes:T:TICRR|TICRR]]|-2.05|0.56|
|[[:human_genes:I:INCENP|INCENP]]|-2.04|0.63|
|[[:human_genes:D:DNAJB8|DNAJB8]]|-2.04|0.53|
|[[:human_genes:P:POLA1|POLA1]]|-2.03|0.75|
|[[:human_genes:P:PSMC6|PSMC6]]|-2.02|0.56|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.01|0.53|
|[[:human_genes:Z:ZNF821|ZNF821]]|-1.98|0.56|
|[[:human_genes:V:VPREB1|VPREB1]]|-1.97|0.56|
|[[:human_genes:C:CACNA1F|CACNA1F]]|-1.97|0.56|
|[[:human_genes:M:MEIG1|MEIG1]]|-1.96|0.69|
|[[:human_genes:H:H2AFZ|H2AFZ]]|2.32|0.04|
|[[:human_genes:R:RPS25|RPS25]]|2.32|0.04|
|[[:human_genes:U:UBQLN1|UBQLN1]]|2.33|0.04|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.37|0.04|
|[[:human_genes:G:GTF3C5|GTF3C5]]|2.37|0.09|
|[[:human_genes:P:PPP6C|PPP6C]]|2.39|0.05|
|[[:human_genes:T:TUT1|TUT1]]|2.40|0.05|
|[[:human_genes:T:THG1L|THG1L]]|2.40|0.05|
|[[:human_genes:M:MOCS3|MOCS3]]|2.41|0.05|
|[[:human_genes:Q:QARS|QARS]]|2.41|0.33|
|[[:human_genes:P:PLAA|PLAA]]|2.42|0.03|
|[[:human_genes:F:FBXO11|FBXO11]]|2.61|0.03|
|[[:human_genes:T:TMED10|TMED10]]|2.66|0.02|
|[[:human_genes:V:VDAC2|VDAC2]]|2.71|<0.01|
|[[:human_genes:I:INO80C|INO80C]]|2.72|<0.01|
|[[:human_genes:C:CTU1|CTU1]]|2.76|<0.01|
|[[:human_genes:I:IKZF1|IKZF1]]|2.88|<0.01|
|[[:human_genes:I:IRF2|IRF2]]|3.09|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|3.11|<0.01|
|[[:human_genes:E:ELP3|ELP3]]|3.14|<0.01|
|[[:human_genes:R:RPTOR|RPTOR]]|3.16|<0.01|
|[[:human_genes:K:KCTD5|KCTD5]]|3.23|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.37|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|3.53|<0.01|
|[[:human_genes:G:GOLGA8H|GOLGA8H]]|3.55|0.03|
|[[:human_genes:G:GUK1|GUK1]]|4.00|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|4.51|<0.01|
|[[:human_genes:S:SLC43A3|SLC43A3]]|4.89|<0.01|
|[[:human_genes:N:NUDT5|NUDT5]]|8.08|<0.01|
|[[:human_genes:H:HPRT1|HPRT1]]|8.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.16|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.118|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.109|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.109|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.101|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.099|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.097|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.096|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.096|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.086|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.084|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.083|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.081|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.077|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.076|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.076|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.076|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.074|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.073|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.071|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.07|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.069|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.069|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.068|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.067|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.063|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.062|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.062|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.062|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.062|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.06|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.057|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.056|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.054|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.053|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.052|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.051|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.105|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.058|<button type="primary" size="small" modal="39">View</button>|
</modal>


<modal id="1" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp259_vs_exp456.png?nolink |}}
</modal>

<modal id="2" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp259.png?nolink |}}
</modal>

<modal id="3" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp259_vs_exp459.png?nolink |}}
</modal>

<modal id="4" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp259.png?nolink |}}
</modal>

<modal id="5" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp259_vs_exp472.png?nolink |}}
</modal>

<modal id="6" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp259_vs_exp80.png?nolink |}}
</modal>

<modal id="7" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp259_vs_exp85.png?nolink |}}
</modal>

<modal id="8" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp259_vs_exp478.png?nolink |}}
</modal>

<modal id="9" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp259_vs_exp531.png?nolink |}}
</modal>

<modal id="10" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp259_vs_exp503.png?nolink |}}
</modal>

<modal id="11" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp259_vs_exp527.png?nolink |}}
</modal>

<modal id="12" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp259_vs_exp3.png?nolink |}}
</modal>

<modal id="13" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp259_vs_exp443.png?nolink |}}
</modal>

<modal id="14" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp259_vs_exp488.png?nolink |}}
</modal>

<modal id="15" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp211_vs_exp259.png?nolink |}}
</modal>

<modal id="16" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp259_vs_exp28.png?nolink |}}
</modal>

<modal id="17" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp259_vs_exp357.png?nolink |}}
</modal>

<modal id="18" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp259_vs_exp489.png?nolink |}}
</modal>

<modal id="19" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp259_vs_exp512.png?nolink |}}
</modal>

<modal id="20" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp259_vs_exp34.png?nolink |}}
</modal>

<modal id="21" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp259_vs_exp515.png?nolink |}}
</modal>

<modal id="22" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp259_vs_exp450.png?nolink |}}
</modal>

<modal id="23" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp259.png?nolink |}}
</modal>

<modal id="24" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp259_vs_exp440.png?nolink |}}
</modal>

<modal id="25" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp259.png?nolink |}}
</modal>

<modal id="26" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  AICAR 240μM R03 exp116">
{{:chemogenomics:comparison_plots:exp116_vs_exp259.png?nolink |}}
</modal>

<modal id="27" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp259_vs_exp355.png?nolink |}}
</modal>

<modal id="28" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp259.png?nolink |}}
</modal>

<modal id="29" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp259_vs_exp451.png?nolink |}}
</modal>

<modal id="30" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp259.png?nolink |}}
</modal>

<modal id="31" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp259_vs_exp524.png?nolink |}}
</modal>

<modal id="32" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp259.png?nolink |}}
</modal>

<modal id="33" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp259_vs_exp485.png?nolink |}}
</modal>

<modal id="34" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp259_vs_exp435.png?nolink |}}
</modal>

<modal id="35" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp259_vs_exp468.png?nolink |}}
</modal>

<modal id="36" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp259_vs_exp502.png?nolink |}}
</modal>

<modal id="37" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  BI-2536 0.02μM R03 exp96">
{{:chemogenomics:comparison_plots:exp259_vs_exp96.png?nolink |}}
</modal>

<modal id="38" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  6-Thio-2-deoxyguanosine 2μM R06 exp259">
{{:chemogenomics:comparison_plots:exp2_vs_exp259.png?nolink |}}
</modal>

<modal id="39" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  6-Thio-2-deoxyguanosine 2μM R06 exp259">
{{:chemogenomics:comparison_plots:exp214_vs_exp259.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|DNA replication checkpoint signaling|108.31|ORC1,CDT1,TICRR|
|regulation of DNA replication|25.15|PPP2CA,CCNA2,CDT1,PPP2R1A,TICRR|
|mitotic cell cycle process|13.03|CKAP5,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1|
|mitotic cell cycle|12.23|CKAP5,PPP2CA,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1|
|regulation of mitotic cell cycle phase transition|11.40|PPP2CA,ORC1,FGF10,WEE1,TICRR,INCENP|
|regulation of cell cycle phase transition|10.33|PPP2CA,ORC1,CDT1,FGF10,WEE1,TICRR,INCENP|
|chromosomal region|9.90|CKAP5,PPP2CA,ORC1,CDT1,PPP2R1A,INCENP|
|cell division|8.47|CKAP5,MAU2,CCNA2,CDT1,PRC1,WEE1,INCENP|
|cell cycle process|8.43|CKAP5,MAU2,CCNA2,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP,POLA1|
|regulation of cell cycle process|7.97|PPP2CA,ORC1,CDT1,PRC1,PPP2R1A,FGF10,WEE1,TICRR,INCENP|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|protein urmylation|368.27|CTU1,MOCS3|
|tRNA thio-modification|276.20|CTU1,MOCS3|
|tRNA wobble uridine modification|103.58|ELP3,CTU1,MOCS3|
|tRNA wobble base modification|87.22|ELP3,CTU1,MOCS3|
|tRNA modification|25.11|ELP3,CTU1,MOCS3,THG1L|
|nucleotidyltransferase activity|20.31|NUDT5,CTU1,MOCS3,THG1L,TUT1|
|tRNA metabolic process|17.92|ELP3,CTU1,QARS1,MOCS3,THG1L,GTF3C5|
|ncRNA metabolic process|8.79|ELP3,CTU1,QARS1,MOCS3,THG1L,TUT1,GTF3C5,RPS25|
|intracellular protein-containing complex|5.68|EIF4A1,KCTD5,RPTOR,ELP3,ENY2,CTU1,FBXO11,QARS1,UBQLN1|
</modal>