====== Pimelic-diphenylamide-106 0.5μM R00 exp27 ======
==== Mechanism of Action ====
Inhibits HDAC3 selectively, benzamide derivative
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Pimelic Diphenylamide 106%%
    * **<color #00a2e8>Synonyms:</color>** RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII; RGFA-8;TC-H 106;Histone Deacetylase Inhibitor VII
    * **<color #00a2e8>CAS #:</color>** 937039-45-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/16070100|16070100]]
    * **<color #00a2e8>IUPAC:</color>** %%N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
    * **<color #00a2e8>INCHI Key:</color>** WTKBRPXPNAKVEQ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 339.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H25N3O2
{{:chemogenomics:structures:chem-0015.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** SML0313
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H25N3O2 340.20195; found 340.20313
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** PD106
    * **<color #00a2e8>Min:</color>** -5.1320; **<color #00a2e8>Max:</color>** 91.7728
{{:chemogenomics:dose_response:dr_106.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.7702    |
| IC30  |1.0245    |
| IC40  |1.2946    |
| IC50  |1.6046    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 500nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.2
    * **<color #00a2e8>Numbers of reads</color>**: 11779532


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|2/3|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Pimelic_Diphenylamide_106_0.5uM_Round-0_exp27.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Pimelic-diphenylamide-106 0.5μM R00 exp27'>
{{:chemogenomics:cranks_plots:exp27.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.95|0.04|
|[[:human_genes:A:ASB3|ASB3]]|-2.91|0.03|
|[[:human_genes:D:DCAF15|DCAF15]]|-2.62|0.11|
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|-2.55|0.54|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|-2.54|0.54|
|[[:human_genes:S:STAG2|STAG2]]|-2.52|0.11|
|[[:human_genes:A:ADK|ADK]]|-2.48|0.11|
|[[:human_genes:R:RPP30|RPP30]]|-2.46|0.11|
|[[:human_genes:P:PDCD5|PDCD5]]|-2.45|0.11|
|[[:human_genes:R:RABIF|RABIF]]|-2.41|0.11|
|[[:human_genes:D:DDX20|DDX20]]|-2.40|0.11|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.31|0.11|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.26|0.35|
|[[:human_genes:G:GFPT1|GFPT1]]|-2.23|0.34|
|[[:human_genes:K:KHDRBS1|KHDRBS1]]|-2.09|0.36|
|[[:human_genes:Z:ZNHIT1|ZNHIT1]]|-2.08|0.34|
|[[:human_genes:T:TAF1B|TAF1B]]|-2.08|0.36|
|[[:human_genes:W:WT1|WT1]]|-2.07|0.34|
|[[:human_genes:R:RPE|RPE]]|-2.07|0.36|
|[[:human_genes:C:CUL2|CUL2]]|-2.06|0.36|
|[[:human_genes:P:PMM2|PMM2]]|-2.05|0.34|
|[[:human_genes:W:WDR61|WDR61]]|-2.05|0.40|
|[[:human_genes:P:PEX1|PEX1]]|-2.04|0.34|
|[[:human_genes:C:CTC1|CTC1]]|-2.03|0.36|
|[[:human_genes:G:GEMIN5|GEMIN5]]|-2.02|0.34|
|[[:human_genes:T:TCF4|TCF4]]|-2.01|0.34|
|[[:human_genes:R:RAB36|RAB36]]|-2.01|0.34|
|[[:human_genes:T:TRMT44|TRMT44]]|-2.01|0.34|
|[[:human_genes:T:TTC39A|TTC39A]]|-2.00|0.36|
|[[:human_genes:F:FCGR3B|FCGR3B]]|-1.99|0.36|
|[[:human_genes:M:MYH2|MYH2]]|2.04|0.48|
|[[:human_genes:N:NDC80|NDC80]]|2.04|0.52|
|[[:human_genes:M:MSH3|MSH3]]|2.05|0.35|
|[[:human_genes:B:BIRC3|BIRC3]]|2.06|0.35|
|[[:human_genes:O:ORC6|ORC6]]|2.07|0.45|
|[[:human_genes:T:TFIP11|TFIP11]]|2.08|0.36|
|[[:human_genes:C:COPE|COPE]]|2.09|0.48|
|[[:human_genes:P:PLEKHA4|PLEKHA4]]|2.09|0.35|
|[[:human_genes:S:SUPT6H|SUPT6H]]|2.10|0.51|
|[[:human_genes:K:KIR3DL3|KIR3DL3]]|2.11|0.35|
|[[:human_genes:S:SULT2B1|SULT2B1]]|2.13|0.35|
|[[:human_genes:O:OR6C68|OR6C68]]|2.15|0.28|
|[[:human_genes:T:TRA2B|TRA2B]]|2.18|0.37|
|[[:human_genes:R:RFFL|RFFL]]|2.19|0.35|
|[[:human_genes:C:CNKSR2|CNKSR2]]|2.21|0.25|
|[[:human_genes:S:STAMBPL1|STAMBPL1]]|2.24|0.23|
|[[:human_genes:T:TRAPPC2L|TRAPPC2L]]|2.24|0.23|
|[[:human_genes:A:ATP2C1|ATP2C1]]|2.28|0.23|
|[[:human_genes:R:RPL34|RPL34]]|2.28|0.48|
|[[:human_genes:P:PROCA1|PROCA1]]|2.28|0.28|
|[[:human_genes:R:RPL37|RPL37]]|2.29|0.48|
|[[:human_genes:T:TPX2|TPX2]]|2.52|0.37|
|[[:human_genes:R:RPL7L1|RPL7L1]]|2.57|0.23|
|[[:human_genes:T:THAP5|THAP5]]|2.66|0.05|
|[[:human_genes:O:OR1L1|OR1L1]]|2.69|0.05|
|[[:human_genes:N:NSA2|NSA2]]|2.79|0.33|
|[[:human_genes:P:POLE|POLE]]|2.79|0.37|
|[[:human_genes:O:OR52D1|OR52D1]]|2.89|0.08|
|[[:human_genes:K:KIF11|KIF11]]|3.30|0.35|
|[[:human_genes:D:DEFB114|DEFB114]]|3.62|0.05|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|0.084|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|0.073|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|0.067|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|0.065|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|0.06|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|0.056|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|0.053|<button type="primary" size="small" modal="7">View</button>|
</modal>


<modal id="1" size="lg" title="Pimelic-diphenylamide-106 0.5μM R00 exp27  vs  Rifampicin 1μM R00 exp31">
{{:chemogenomics:comparison_plots:exp27_vs_exp31.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Pimelic-diphenylamide-106 0.5μM R00 exp27  vs  Wortmannin 0.5μM R00 exp37">
{{:chemogenomics:comparison_plots:exp27_vs_exp37.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Nocodazole 0.02μM R00 exp23  vs  Pimelic-diphenylamide-106 0.5μM R00 exp27">
{{:chemogenomics:comparison_plots:exp23_vs_exp27.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Cycloheximide 0.02μM R00 exp14  vs  Pimelic-diphenylamide-106 0.5μM R00 exp27">
{{:chemogenomics:comparison_plots:exp14_vs_exp27.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Alpha-Amanitin 0.5μM R00 exp5  vs  Pimelic-diphenylamide-106 0.5μM R00 exp27">
{{:chemogenomics:comparison_plots:exp27_vs_exp5.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Doxycycline 10μM R00 exp18  vs  Pimelic-diphenylamide-106 0.5μM R00 exp27">
{{:chemogenomics:comparison_plots:exp18_vs_exp27.png?nolink |}}
</modal>

<modal id="7" size="lg" title="5-Fluorouracil 2μM R00 exp1  vs  Pimelic-diphenylamide-106 0.5μM R00 exp27">
{{:chemogenomics:comparison_plots:exp1_vs_exp27.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>