====== Actinomycin-D 0.001μM R00 exp3 ======
==== Mechanism of Action ====
Inhibits RNA polymerases, intercalates DNA, prevents chain elongation
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Transcription Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dactinomycin%%
    * **<color #00a2e8>Synonyms:</color>** Dactinomycin; Actinomycin IV
    * **<color #00a2e8>CAS #:</color>** 50-76-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/457193|457193]]
    * **<color #00a2e8>IUPAC:</color>** %%2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** RJURFGZVJUQBHK-IIXSONLDSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 1255.4
    * **<color #00a2e8>Canonical SMILES:</color>** CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
    * **<color #00a2e8>Molecular Formula:</color>** C62H86N12O16
{{:chemogenomics:structures:chem-0002.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** A1410
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C62H86N12O16 1255.63575; found 1255.63738
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Actinomycin_D
    * **<color #00a2e8>Min:</color>** -23.7457; **<color #00a2e8>Max:</color>** 97.9710
{{:chemogenomics:dose_response:dr_254.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0002    |
| IC30  |0.0002    |
| IC40  |0.0002    |
| IC50  |0.0002    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 1nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.7
    * **<color #00a2e8>Numbers of reads</color>**: 9813688


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|15/132|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Actinomycin_D_0.001uM_Round-0_exp3.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Actinomycin-D 0.001μM R00 exp3'>
{{:chemogenomics:cranks_plots:exp3.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MSI2|MSI2]]|-3.40|<0.01|
|[[:human_genes:P:PSMC5|PSMC5]]|-3.21|0.05|
|[[:human_genes:W:WAPAL|WAPAL]]|-3.20|<0.01|
|[[:human_genes:S:SF3A1|SF3A1]]|-2.98|0.29|
|[[:human_genes:V:VPS51|VPS51]]|-2.96|0.01|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.95|<0.01|
|[[:human_genes:S:SIN3A|SIN3A]]|-2.85|0.02|
|[[:human_genes:H:HEXIM1|HEXIM1]]|-2.85|0.01|
|[[:human_genes:B:BRD2|BRD2]]|-2.69|0.02|
|[[:human_genes:T:TCF3|TCF3]]|-2.65|0.03|
|[[:human_genes:A:ATP6AP2|ATP6AP2]]|-2.65|0.07|
|[[:human_genes:X:XPO1|XPO1]]|-2.65|0.28|
|[[:human_genes:A:ABCB4|ABCB4]]|-2.65|0.03|
|[[:human_genes:L:LGI4|LGI4]]|-2.64|0.02|
|[[:human_genes:T:TCF4|TCF4]]|-2.59|0.03|
|[[:human_genes:A:ATXN2L|ATXN2L]]|-2.58|0.04|
|[[:human_genes:E:EP300|EP300]]|-2.53|0.22|
|[[:human_genes:T:TSC2|TSC2]]|-2.51|0.03|
|[[:human_genes:I:ING1|ING1]]|-2.46|0.04|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-2.42|0.37|
|[[:human_genes:G:GTPBP4|GTPBP4]]|-2.38|0.16|
|[[:human_genes:P:PSMB3|PSMB3]]|-2.36|0.11|
|[[:human_genes:D:DHX8|DHX8]]|-2.33|0.31|
|[[:human_genes:T:TCF12|TCF12]]|-2.30|0.13|
|[[:human_genes:Z:ZCCHC4|ZCCHC4]]|-2.29|0.17|
|[[:human_genes:E:ERCC3|ERCC3]]|-2.29|0.17|
|[[:human_genes:O:OSBP|OSBP]]|-2.25|0.33|
|[[:human_genes:C:COX7A2L|COX7A2L]]|-2.24|0.11|
|[[:human_genes:N:NUP133|NUP133]]|-2.24|0.18|
|[[:human_genes:S:SLC22A14|SLC22A14]]|-2.21|0.12|
|[[:human_genes:R:RB1|RB1]]|3.94|<0.01|
|[[:human_genes:R:RPL5|RPL5]]|4.00|<0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|4.04|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|4.08|<0.01|
|[[:human_genes:M:MCL1|MCL1]]|4.09|<0.01|
|[[:human_genes:C:CDKN1A|CDKN1A]]|4.20|<0.01|
|[[:human_genes:P:PPP6C|PPP6C]]|4.21|<0.01|
|[[:human_genes:S:SUV420H1|SUV420H1]]|4.29|<0.01|
|[[:human_genes:R:RIOK3|RIOK3]]|4.40|<0.01|
|[[:human_genes:G:GTF3A|GTF3A]]|4.59|<0.01|
|[[:human_genes:M:MEAF6|MEAF6]]|4.69|<0.01|
|[[:human_genes:D:DIABLO|DIABLO]]|4.77|<0.01|
|[[:human_genes:U:UBE2K|UBE2K]]|4.79|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|4.80|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|4.95|<0.01|
|[[:human_genes:S:SPOP|SPOP]]|5.00|<0.01|
|[[:human_genes:X:XPO7|XPO7]]|5.15|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|5.29|<0.01|
|[[:human_genes:N:NXT1|NXT1]]|5.41|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|5.60|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|5.97|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|6.12|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|6.28|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|6.40|<0.01|
|[[:human_genes:H:HEATR3|HEATR3]]|6.60|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|6.90|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|7.03|<0.01|
|[[:human_genes:R:RPL11|RPL11]]|7.54|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|7.94|<0.01|
|[[:human_genes:T:TP53|TP53]]|8.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.165|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.158|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.148|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.148|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.127|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.124|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.123|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.12|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.119|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.119|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.111|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.11|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.106|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.105|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.103|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.096|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.091|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.088|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.083|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.081|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.081|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.079|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.078|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.074|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.071|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.071|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.07|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.068|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.064|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.064|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.062|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.062|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.06|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.058|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.058|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.058|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.056|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.056|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|0.056|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.055|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.055|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|0.055|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.053|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.053|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|0.052|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.052|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.051|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.051|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.31|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.111|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.087|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.083|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.069|<button type="primary" size="small" modal="53">View</button>|
</modal>


<modal id="1" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp3.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp3_vs_exp34.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp3.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp3.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp3_vs_exp456.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp3_vs_exp478.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp3_vs_exp503.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp3_vs_exp485.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  MLN-4924 2μM R00 exp22">
{{:chemogenomics:comparison_plots:exp22_vs_exp3.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp3_vs_exp459.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp3_vs_exp80.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp3_vs_exp472.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp3_vs_exp531.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp3.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp3.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp3_vs_exp524.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp3_vs_exp440.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp3_vs_exp489.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp3_vs_exp515.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp3_vs_exp488.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp3_vs_exp512.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp3_vs_exp527.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp3_vs_exp357.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Bortezomib 0.05μM R00 exp7">
{{:chemogenomics:comparison_plots:exp3_vs_exp7.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp3_vs_exp443.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp3_vs_exp85.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Atovaquone 15μM R08 exp451">
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</modal>

<modal id="28" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  JQ1 0.8μM R08 exp435">
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</modal>

<modal id="29" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  DABN 20μM R00 exp17">
{{:chemogenomics:comparison_plots:exp17_vs_exp3.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp3.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Pyridostatin 4μM R05 exp240">
{{:chemogenomics:comparison_plots:exp240_vs_exp3.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Dinaciclib 0.007μM R07 exp355">
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</modal>

<modal id="33" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  MLN-4924 0.2μM R00 exp21">
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</modal>

<modal id="34" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp3.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Diepoxybutane 3μM R07 exp354">
{{:chemogenomics:comparison_plots:exp3_vs_exp354.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp3_vs_exp350.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  CR131-b 0.005μM R08 exp474">
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</modal>

<modal id="38" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp3_vs_exp33.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  BI-D1870 3.15μM R02 exp66">
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</modal>

<modal id="40" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp3_vs_exp468.png?nolink |}}
</modal>

<modal id="41" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  LY2090314 0.003μM R08 exp499">
{{:chemogenomics:comparison_plots:exp3_vs_exp499.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  THZ531 0.225μM R08 exp444">
{{:chemogenomics:comparison_plots:exp3_vs_exp444.png?nolink |}}
</modal>

<modal id="43" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp3_vs_exp448.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp3_vs_exp441.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  TRAIL 5ng/ml R00 exp35">
{{:chemogenomics:comparison_plots:exp3_vs_exp35.png?nolink |}}
</modal>

<modal id="46" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp3_vs_exp59.png?nolink |}}
</modal>

<modal id="47" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp3_vs_exp502.png?nolink |}}
</modal>

<modal id="48" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp3_vs_exp500.png?nolink |}}
</modal>

<modal id="49" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp2_vs_exp3.png?nolink |}}
</modal>

<modal id="50" size="lg" title="AICAR 240μM R05 exp211  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp211_vs_exp3.png?nolink |}}
</modal>

<modal id="51" size="lg" title="AICAR 240μM R03 exp116  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp116_vs_exp3.png?nolink |}}
</modal>

<modal id="52" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp259_vs_exp3.png?nolink |}}
</modal>

<modal id="53" size="lg" title="42°C R08 exp539  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp3_vs_exp539.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.73|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|442.19|APAF1,CASP9,CYCS,DIABLO|
|glial cell apoptotic process|414.55|TP53,CASP9,RB1|
|5S rRNA binding|207.28|RPL11,GTF3A,RPL5|
|release of cytochrome c from mitochondria|78.96|TP53,BAK1,MCL1|
|apoptotic mitochondrial changes|39.48|TP53,BAK1,VDAC2,MCL1|
|intrinsic apoptotic signaling pathway in response to DNA damage|38.92|TP53,BAK1,CASP9,CDKN1A,MCL1|
|intrinsic apoptotic signaling pathway|27.64|TP53,BAK1,APAF1,CASP9,CYCS,DIABLO,CDKN1A,MCL1|
|neuron apoptotic process|27.36|TP53,APAF1,CASP9,DIABLO,RB1|
|positive regulation of cysteine-type endopeptidase activity|22.29|BAK1,APAF1,CASP9,CYCS,DIABLO|
|positive regulation of endopeptidase activity|19.06|BAK1,APAF1,CASP9,CYCS,DIABLO|
|apoptotic signaling pathway|16.15|TP53,BAK1,APAF1,CASP9,VDAC2,CYCS,DIABLO,CDKN1A,MCL1|
|ubiquitin protein ligase binding|14.79|TP53,RPL11,SPOP,FAF2,UBE2K,CDKN1A,RPL5,RB1|
|nuclear transport|14.11|TP53,HEATR3,ENY2,NXT1,XPO7,CDKN1A|
|nucleocytoplasmic transport|14.11|TP53,HEATR3,ENY2,NXT1,XPO7,CDKN1A|
|ubiquitin-like protein ligase binding|13.95|TP53,RPL11,SPOP,FAF2,UBE2K,CDKN1A,RPL5,RB1|
|regulation of apoptotic signaling pathway|11.79|TP53,RPL11,BAK1,UBQLN1,APAF1,VDAC2,MCL1,RB1|
|regulation of proteolysis|10.31|TP53,RPL11,BAK1,UBQLN1,APAF1,CASP9,SPOP,CYCS,UBE2K,DIABLO,RPL5|
|positive regulation of programmed cell death|8.69|TP53,RPL11,BAK1,APAF1,CASP9,DIABLO,CDKN1A,MCL1|
</modal>