====== Dexamethasone 0.006μM R07 exp351 ======
==== Mechanism of Action ====
Glucocorticoid receptor agonist, anti-inflammatory
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Hormone Agonist
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / GPCR Agonist



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Dexamethasone%%
    * **<color #00a2e8>Synonyms:</color>** Hexadecadrol; Prednisolone F
    * **<color #00a2e8>CAS #:</color>** 50-02-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5743|5743]]
    * **<color #00a2e8>IUPAC:</color>** %%(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** UREBDLICKHMUKA-CXSFZGCWSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 392.5
    * **<color #00a2e8>Canonical SMILES:</color>** CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
    * **<color #00a2e8>Molecular Formula:</color>** C22H29FO5
{{:chemogenomics:structures:chem-0208.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** D4902
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C22H29FO5 393.20718; found 393.2068
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Dexamethasone
    * **<color #00a2e8>Min:</color>** -4.7517; **<color #00a2e8>Max:</color>** 71.3612
{{:chemogenomics:dose_response:dr_463.png?nolink&500 |}}
\\ 
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\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.0111    |
| IC30  |0.0159    |
| IC40  |0.0223    |
| IC50  |0.0178    |
| IC60  |N/A    |
| IC70  |0.2312    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 07
    * **<color #00a2e8>Dose</color>**: 6nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.0
    * **<color #00a2e8>Numbers of reads</color>**: 21288604


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|10/12|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Dexamethasone_0.006uM_Round-7_exp351.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Dexamethasone 0.006μM R07 exp351'>
{{:chemogenomics:cranks_plots:exp351.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:N:NRAS|NRAS]]|-3.39|<0.01|
|[[:human_genes:C:CREBBP|CREBBP]]|-2.97|0.02|
|[[:human_genes:S:SHOC2|SHOC2]]|-2.86|0.02|
|[[:human_genes:N:NFKBIA|NFKBIA]]|-2.74|0.02|
|[[:human_genes:F:FKBP5|FKBP5]]|-2.68|0.02|
|[[:human_genes:C:CYLD|CYLD]]|-2.62|0.03|
|[[:human_genes:D:DPH1|DPH1]]|-2.59|0.03|
|[[:human_genes:L:LDB1|LDB1]]|-2.53|0.04|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.52|0.12|
|[[:human_genes:D:DPH5|DPH5]]|-2.48|0.04|
|[[:human_genes:T:TRIM33|TRIM33]]|-2.45|0.05|
|[[:human_genes:R:RPL36A-HNRNPH2|RPL36A-HNRNPH2]]|-2.45|0.59|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|-2.40|0.06|
|[[:human_genes:A:ASB3|ASB3]]|-2.38|0.12|
|[[:human_genes:H:HLA-DRA|HLA-DRA]]|-2.35|0.07|
|[[:human_genes:A:ABHD5|ABHD5]]|-2.34|0.12|
|[[:human_genes:G:GPR75-ASB3|GPR75-ASB3]]|-2.28|0.16|
|[[:human_genes:K:KDM5A|KDM5A]]|-2.24|0.12|
|[[:human_genes:P:PIK3CD|PIK3CD]]|-2.23|0.12|
|[[:human_genes:T:TP53RK|TP53RK]]|-2.16|0.30|
|[[:human_genes:L:LAMTOR4|LAMTOR4]]|-2.16|0.22|
|[[:human_genes:W:WDR59|WDR59]]|-2.14|0.16|
|[[:human_genes:S:ST6GALNAC2|ST6GALNAC2]]|-2.13|0.16|
|[[:human_genes:D:DAZAP2|DAZAP2]]|-2.13|0.24|
|[[:human_genes:R:RSRC2|RSRC2]]|-2.13|0.61|
|[[:human_genes:C:CTCF|CTCF]]|-2.11|0.24|
|[[:human_genes:S:SSBP2|SSBP2]]|-2.11|0.17|
|[[:human_genes:C:CHKA|CHKA]]|-2.07|0.21|
|[[:human_genes:M:MT1H|MT1H]]|-2.07|0.47|
|[[:human_genes:D:DCDC2C|DCDC2C]]|-2.06|0.21|
|[[:human_genes:S:SF3A3|SF3A3]]|2.14|0.47|
|[[:human_genes:S:STIP1|STIP1]]|2.17|0.27|
|[[:human_genes:T:TCF3|TCF3]]|2.18|0.27|
|[[:human_genes:S:SURF1|SURF1]]|2.19|0.13|
|[[:human_genes:M:MLPH|MLPH]]|2.24|0.10|
|[[:human_genes:C:CABP4|CABP4]]|2.25|0.10|
|[[:human_genes:G:GPS2|GPS2]]|2.26|0.15|
|[[:human_genes:M:MED17|MED17]]|2.26|0.15|
|[[:human_genes:A:ARID3A|ARID3A]]|2.28|0.24|
|[[:human_genes:P:PRKG2|PRKG2]]|2.29|0.14|
|[[:human_genes:S:STIL|STIL]]|2.31|0.13|
|[[:human_genes:G:GSK3B|GSK3B]]|2.32|0.07|
|[[:human_genes:K:KPTN|KPTN]]|2.38|0.05|
|[[:human_genes:D:DPEP1|DPEP1]]|2.40|0.05|
|[[:human_genes:P:POLE2|POLE2]]|2.42|0.34|
|[[:human_genes:G:GAGE12H|GAGE12H]]|2.51|0.20|
|[[:human_genes:E:EIF3A|EIF3A]]|2.52|0.03|
|[[:human_genes:N:NPY4R|NPY4R]]|2.53|0.05|
|[[:human_genes:H:HMGXB4|HMGXB4]]|2.53|0.03|
|[[:human_genes:N:NANS|NANS]]|2.53|0.03|
|[[:human_genes:C:CHAF1A|CHAF1A]]|2.57|0.16|
|[[:human_genes:U:UBE2H|UBE2H]]|2.72|0.01|
|[[:human_genes:P:PTGES3|PTGES3]]|2.84|<0.01|
|[[:human_genes:A:AXIN1|AXIN1]]|2.89|0.01|
|[[:human_genes:A:ACTB|ACTB]]|3.03|<0.01|
|[[:human_genes:E:EIF4B|EIF4B]]|3.03|<0.01|
|[[:human_genes:S:SCAP|SCAP]]|3.32|<0.01|
|[[:human_genes:Y:YPEL5|YPEL5]]|3.48|<0.01|
|[[:human_genes:T:TSC2|TSC2]]|4.03|<0.01|
|[[:human_genes:N:NR3C1|NR3C1]]|5.34|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|0.077|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|0.063|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|0.06|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.059|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|0.056|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|0.055|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.054|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|0.228|<button type="primary" size="small" modal="8">View</button>|
</modal>


<modal id="1" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307">
{{:chemogenomics:comparison_plots:exp307_vs_exp351.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Wortmannin 5μM R00 exp38">
{{:chemogenomics:comparison_plots:exp351_vs_exp38.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Rapamycin 0.001μM R08 exp429">
{{:chemogenomics:comparison_plots:exp351_vs_exp429.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Rapamycin 1μM R00 exp29">
{{:chemogenomics:comparison_plots:exp29_vs_exp351.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Rapamycin 2μM plus FK-506 5μM R07 exp308">
{{:chemogenomics:comparison_plots:exp308_vs_exp351.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Tunicamycin 0.04μM R07 exp418">
{{:chemogenomics:comparison_plots:exp351_vs_exp418.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Dexamethasone 0.006μM R07 exp351  vs  Rapamycin 10μM R00 exp30">
{{:chemogenomics:comparison_plots:exp30_vs_exp351.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Dexamethasone 0.006 to 0.015μM on day4 R07 exp352  vs  Dexamethasone 0.006μM R07 exp351">
{{:chemogenomics:comparison_plots:exp351_vs_exp352.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|Hsp90 protein binding|55.26|NR3C1,TSC2,PTGES3,STIP1|
</modal>