====== Aphidicolin 0.4μM R08 exp440 ======
==== Mechanism of Action ====
Inhibits DNA polymerases Polα, Polδ, Polϵ and Polζ
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Replication Inhibitor
  * **<color #00a2e8>Class / Subclass 2:</color>** Cell Cycle / Replication Inhibitor
  * **<color #00a2e8>Class / Subclass 3:</color>** Infectious Disease / Antiviral


==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Aphidicolin%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 38966-21-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/457964|457964]]
    * **<color #00a2e8>IUPAC:</color>** %%(1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** NOFOAYPPHIUXJR-APNQCZIXSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 338.5
    * **<color #00a2e8>Canonical SMILES:</color>** CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
    * **<color #00a2e8>Molecular Formula:</color>** C20H34O4
{{:chemogenomics:structures:chem-0157.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** A726260
    * **<color #00a2e8>Lot #:</color>** 1-TSS-153-1
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C20H34O4 361.23493; found 361.23594
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Aphidicolin_A
    * **<color #00a2e8>Min:</color>** -33.0803; **<color #00a2e8>Max:</color>** 90.7760
{{:chemogenomics:dose_response:dr_498.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |0.2361    |
| IC20  |0.3133    |
| IC30  |0.3781    |
| IC40  |0.4411    |
| IC50  |0.5081    |
| IC60  |0.5853    |
| IC70  |0.6828    |
| IC80  |0.8240    |
| IC90  |1.0930    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 400nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.9
    * **<color #00a2e8>Numbers of reads</color>**: 16794216


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|26/94|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Aphidicolin_0.4uM_Round-8_exp440.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Aphidicolin 0.4μM R08 exp440'>
{{:chemogenomics:cranks_plots:exp440.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GTPBP2|GTPBP2]]|-4.72|<0.01|
|[[:human_genes:O:OTUB1|OTUB1]]|-3.78|<0.01|
|[[:human_genes:D:DERA|DERA]]|-3.72|<0.01|
|[[:human_genes:K:KPNA4|KPNA4]]|-3.37|<0.01|
|[[:human_genes:M:MSI2|MSI2]]|-3.23|<0.01|
|[[:human_genes:A:ANKRD32|ANKRD32]]|-3.11|<0.01|
|[[:human_genes:R:RECQL5|RECQL5]]|-3.00|<0.01|
|[[:human_genes:D:DCK|DCK]]|-2.91|<0.01|
|[[:human_genes:R:RING1|RING1]]|-2.74|0.02|
|[[:human_genes:T:TMOD4|TMOD4]]|-2.72|0.02|
|[[:human_genes:A:ALDH16A1|ALDH16A1]]|-2.71|0.01|
|[[:human_genes:U:UBE2N|UBE2N]]|-2.63|0.02|
|[[:human_genes:S:SPEN|SPEN]]|-2.61|0.02|
|[[:human_genes:U:UXS1|UXS1]]|-2.58|0.02|
|[[:human_genes:V:VPS25|VPS25]]|-2.53|0.27|
|[[:human_genes:G:GIGYF2|GIGYF2]]|-2.52|0.04|
|[[:human_genes:S:SMG7|SMG7]]|-2.52|0.04|
|[[:human_genes:I:INTS12|INTS12]]|-2.51|0.02|
|[[:human_genes:P:PDS5B|PDS5B]]|-2.49|0.02|
|[[:human_genes:P:PCGF1|PCGF1]]|-2.48|0.02|
|[[:human_genes:T:TRAF2|TRAF2]]|-2.47|0.04|
|[[:human_genes:P:PSME3|PSME3]]|-2.47|0.02|
|[[:human_genes:S:SMARCAL1|SMARCAL1]]|-2.44|0.03|
|[[:human_genes:T:TRMT44|TRMT44]]|-2.44|0.03|
|[[:human_genes:C:CSE1L|CSE1L]]|-2.42|0.14|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.41|0.06|
|[[:human_genes:U:UBE2D2|UBE2D2]]|-2.41|0.03|
|[[:human_genes:P:PSMB1|PSMB1]]|-2.36|0.10|
|[[:human_genes:U:UBE2E1|UBE2E1]]|-2.33|0.04|
|[[:human_genes:O:OR51S1|OR51S1]]|-2.33|0.04|
|[[:human_genes:Z:ZNF330|ZNF330]]|2.83|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|2.83|<0.01|
|[[:human_genes:S:SLC39A10|SLC39A10]]|2.88|<0.01|
|[[:human_genes:K:KLF16|KLF16]]|2.92|<0.01|
|[[:human_genes:C:CD19|CD19]]|2.94|<0.01|
|[[:human_genes:N:NSD1|NSD1]]|2.97|<0.01|
|[[:human_genes:T:TP53|TP53]]|2.99|<0.01|
|[[:human_genes:A:ATP2A2|ATP2A2]]|3.00|0.12|
|[[:human_genes:I:IRF1|IRF1]]|3.02|0.00|
|[[:human_genes:R:RAD23B|RAD23B]]|3.06|<0.01|
|[[:human_genes:T:TRMT61A|TRMT61A]]|3.18|<0.01|
|[[:human_genes:R:RICTOR|RICTOR]]|3.23|0.00|
|[[:human_genes:A:APAF1|APAF1]]|3.25|0.00|
|[[:human_genes:R:RMI2|RMI2]]|3.27|0.00|
|[[:human_genes:D:DOHH|DOHH]]|3.34|0.00|
|[[:human_genes:K:KCTD5|KCTD5]]|3.36|0.00|
|[[:human_genes:C:CD81|CD81]]|3.36|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|3.39|0.00|
|[[:human_genes:A:AHCYL1|AHCYL1]]|3.44|0.00|
|[[:human_genes:M:MLST8|MLST8]]|3.57|0.00|
|[[:human_genes:H:HCCS|HCCS]]|3.61|0.00|
|[[:human_genes:C:CASP9|CASP9]]|3.68|0.00|
|[[:human_genes:Y:YARS2|YARS2]]|3.68|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|3.76|0.00|
|[[:human_genes:S:SLFN11|SLFN11]]|3.93|0.00|
|[[:human_genes:P:PLAA|PLAA]]|4.10|0.00|
|[[:human_genes:P:PIK3CD|PIK3CD]]|4.25|0.00|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.59|0.00|
|[[:human_genes:B:BAK1|BAK1]]|5.73|0.00|
|[[:human_genes:F:FBXO11|FBXO11]]|5.93|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.16|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.152|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.146|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.14|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.138|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.134|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.13|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.126|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.122|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.112|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.109|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.103|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.103|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.1|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.1|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.1|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.099|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.098|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.098|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.096|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.095|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.094|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.092|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.092|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.085|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.085|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.084|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.082|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.081|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.081|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.08|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.079|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.079|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.078|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.078|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|0.076|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.074|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.072|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.071|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.071|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.07|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.069|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp532|TIC10 10μM R08 exp532]]|0.066|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.065|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.064|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.064|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.064|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.063|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.062|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|0.062|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.062|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|0.06|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.058|<button type="primary" size="small" modal="53">View</button>|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|0.057|<button type="primary" size="small" modal="54">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.056|<button type="primary" size="small" modal="55">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.055|<button type="primary" size="small" modal="56">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.054|<button type="primary" size="small" modal="57">View</button>|
|[[:results:exp360|Genistein 15μM R07 exp360]]|0.054|<button type="primary" size="small" modal="58">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.053|<button type="primary" size="small" modal="59">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.052|<button type="primary" size="small" modal="60">View</button>|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|0.052|<button type="primary" size="small" modal="61">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.051|<button type="primary" size="small" modal="62">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.115|<button type="primary" size="small" modal="63">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.113|<button type="primary" size="small" modal="64">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.107|<button type="primary" size="small" modal="65">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.091|<button type="primary" size="small" modal="66">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.071|<button type="primary" size="small" modal="67">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.068|<button type="primary" size="small" modal="68">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.062|<button type="primary" size="small" modal="69">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.062|<button type="primary" size="small" modal="70">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.054|<button type="primary" size="small" modal="71">View</button>|
</modal>


<modal id="1" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp440_vs_exp512.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp440_vs_exp456.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp440_vs_exp488.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp440_vs_exp503.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp440_vs_exp489.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Hydroxyurea 100μM R07 exp329">
{{:chemogenomics:comparison_plots:exp329_vs_exp440.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp440_vs_exp451.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp440_vs_exp472.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp440.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp440_vs_exp529.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp440_vs_exp478.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp440.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp440_vs_exp535.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp440_vs_exp524.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp440_vs_exp459.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp440_vs_exp515.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp440.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp440_vs_exp441.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp440_vs_exp527.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp440_vs_exp78.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp440_vs_exp531.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp440_vs_exp525.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp440_vs_exp450.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp440_vs_exp443.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp357_vs_exp440.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp440.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Diepoxybutane 3μM R07 exp354">
{{:chemogenomics:comparison_plots:exp354_vs_exp440.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp440_vs_exp517.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp440_vs_exp526.png?nolink |}}
</modal>

<modal id="30" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp440.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp440.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp440.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp440_vs_exp485.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp350_vs_exp440.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp440_vs_exp474.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp440.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp440_vs_exp500.png?nolink |}}
</modal>

<modal id="38" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp440_vs_exp80.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp440_vs_exp468.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp440.png?nolink |}}
</modal>

<modal id="41" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp294_vs_exp440.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp440_vs_exp520.png?nolink |}}
</modal>

<modal id="43" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  TIC10 10μM R08 exp532">
{{:chemogenomics:comparison_plots:exp440_vs_exp532.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp440_vs_exp84.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp440_vs_exp502.png?nolink |}}
</modal>

<modal id="46" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp440_vs_exp85.png?nolink |}}
</modal>

<modal id="47" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp440.png?nolink |}}
</modal>

<modal id="48" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp440_vs_exp492.png?nolink |}}
</modal>

<modal id="49" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp440.png?nolink |}}
</modal>

<modal id="50" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  LLY-283 2.6μM R06 exp290">
{{:chemogenomics:comparison_plots:exp290_vs_exp440.png?nolink |}}
</modal>

<modal id="51" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp355_vs_exp440.png?nolink |}}
</modal>

<modal id="52" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  ONC212 0.15μM R08 exp513">
{{:chemogenomics:comparison_plots:exp440_vs_exp513.png?nolink |}}
</modal>

<modal id="53" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp374_vs_exp440.png?nolink |}}
</modal>

<modal id="54" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  TRAIL 50ng/ml R00 exp36">
{{:chemogenomics:comparison_plots:exp36_vs_exp440.png?nolink |}}
</modal>

<modal id="55" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  ML-792 0.2μM R08 exp505">
{{:chemogenomics:comparison_plots:exp440_vs_exp505.png?nolink |}}
</modal>

<modal id="56" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  LY2090314 0.003μM R08 exp499">
{{:chemogenomics:comparison_plots:exp440_vs_exp499.png?nolink |}}
</modal>

<modal id="57" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  BVD-523 15μM R02 exp67">
{{:chemogenomics:comparison_plots:exp440_vs_exp67.png?nolink |}}
</modal>

<modal id="58" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Genistein 15μM R07 exp360">
{{:chemogenomics:comparison_plots:exp360_vs_exp440.png?nolink |}}
</modal>

<modal id="59" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Lead acetate 2000μM R08 exp497">
{{:chemogenomics:comparison_plots:exp440_vs_exp497.png?nolink |}}
</modal>

<modal id="60" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp440.png?nolink |}}
</modal>

<modal id="61" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  CoCl2 18μM R07 exp346">
{{:chemogenomics:comparison_plots:exp346_vs_exp440.png?nolink |}}
</modal>

<modal id="62" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp440.png?nolink |}}
</modal>

<modal id="63" size="lg" title="AICAR 240μM R05 exp211  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp211_vs_exp440.png?nolink |}}
</modal>

<modal id="64" size="lg" title="AICAR 240μM R03 exp116  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp116_vs_exp440.png?nolink |}}
</modal>

<modal id="65" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp2_vs_exp440.png?nolink |}}
</modal>

<modal id="66" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp3_vs_exp440.png?nolink |}}
</modal>

<modal id="67" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp440_vs_exp448.png?nolink |}}
</modal>

<modal id="68" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp259_vs_exp440.png?nolink |}}
</modal>

<modal id="69" size="lg" title="42°C R08 exp539  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp440_vs_exp539.png?nolink |}}
</modal>

<modal id="70" size="lg" title="Amiloride 100μM R08 exp447  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp440_vs_exp447.png?nolink |}}
</modal>

<modal id="71" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp175_vs_exp440.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.63|CASP9,APAF1|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.58|CASP9,APAF1,CYCS|
|glial cell apoptotic process|276.32|CASP9,TP53|
|porin activity|221.05|BAK1,VDAC2|
|TORC2 complex|207.24|MAPKAP1,MLST8,RICTOR|
|positive regulation of mitochondrial membrane permeability|59.21|BAK1,VDAC2,TP53|
|positive regulation of membrane permeability|53.48|BAK1,VDAC2,TP53|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|50.24|BAK1,APAF1,TP53|
|TOR signaling|47.37|MAPKAP1,MLST8,RICTOR|
|intrinsic apoptotic signaling pathway|17.27|BAK1,CASP9,APAF1,TP53,CYCS|
|cellular response to external stimulus|10.14|BAK1,MAPKAP1,MLST8,RICTOR,IRF1,TP53|
</modal>