====== Docetaxel 0.002μM R01 exp45 ======
==== Mechanism of Action ====
Inihibts microtubule depolymerization, semi-synthetic analog of the paclitaxel
  * **<color #00a2e8>Class / Subclass 1:</color>** Cell Cycle / Microtubule Poison
  * **<color #00a2e8>Class / Subclass 2:</color>** Organelle Function / Cytoskeletal Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Docetaxel%%
    * **<color #00a2e8>Synonyms:</color>** RP-56976
    * **<color #00a2e8>CAS #:</color>** 114977-28-5
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/148124|148124]]
    * **<color #00a2e8>IUPAC:</color>** %%[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** ZDZOTLJHXYCWBA-VCVYQWHSSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 807.9
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
    * **<color #00a2e8>Molecular Formula:</color>** C43H53NO14
{{:chemogenomics:structures:chem-0025.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Abcam
    * **<color #00a2e8>Catalog #:</color>** AB141248
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C43H53NO14 830.33583; found 830.33216
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DOCETAXEL
    * **<color #00a2e8>Min:</color>** 6.3537; **<color #00a2e8>Max:</color>** 75.1022
{{:chemogenomics:dose_response:dr_78.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |0.0002    |
| IC40  |0.0006    |
| IC50  |0.0020    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 01
    * **<color #00a2e8>Dose</color>**: 2nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.2
    * **<color #00a2e8>Numbers of reads</color>**: 15167862


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|13/3|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Docetaxel_0.002uM_Round-1_exp45.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Docetaxel 0.002μM R01 exp45'>
{{:chemogenomics:cranks_plots:exp45.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:K:KIF18B|KIF18B]]|-3.67|<0.01|
|[[:human_genes:G:GNA13|GNA13]]|-3.66|<0.01|
|[[:human_genes:R:RHOA|RHOA]]|-3.60|<0.01|
|[[:human_genes:K:KIF2A|KIF2A]]|-3.40|<0.01|
|[[:human_genes:A:ATP8B2|ATP8B2]]|-3.31|<0.01|
|[[:human_genes:T:TRIP13|TRIP13]]|-3.24|<0.01|
|[[:human_genes:T:TMEM30A|TMEM30A]]|-3.18|<0.01|
|[[:human_genes:K:KATNA1|KATNA1]]|-3.12|<0.01|
|[[:human_genes:K:KIF2C|KIF2C]]|-2.89|<0.01|
|[[:human_genes:L:LIG4|LIG4]]|-2.84|0.17|
|[[:human_genes:E:ENPP2|ENPP2]]|-2.78|0.04|
|[[:human_genes:H:HERC1|HERC1]]|-2.75|0.04|
|[[:human_genes:R:RIC8A|RIC8A]]|-2.73|<0.01|
|[[:human_genes:D:DLGAP5|DLGAP5]]|-2.65|0.17|
|[[:human_genes:T:TACC3|TACC3]]|-2.61|0.17|
|[[:human_genes:K:KCTD5|KCTD5]]|-2.59|0.18|
|[[:human_genes:K:KIAA0247|KIAA0247]]|-2.48|0.04|
|[[:human_genes:B:BCORL1|BCORL1]]|-2.47|0.33|
|[[:human_genes:K:KLHL9|KLHL9]]|-2.45|0.33|
|[[:human_genes:T:TP53INP2|TP53INP2]]|-2.41|0.28|
|[[:human_genes:G:GSG2|GSG2]]|-2.39|0.12|
|[[:human_genes:C:CTPS1|CTPS1]]|-2.38|0.31|
|[[:human_genes:F:FRG2|FRG2]]|-2.36|0.21|
|[[:human_genes:L:LIN9|LIN9]]|-2.35|0.37|
|[[:human_genes:T:TRAF3|TRAF3]]|-2.33|0.33|
|[[:human_genes:A:ACACA|ACACA]]|-2.30|0.23|
|[[:human_genes:G:GTSE1|GTSE1]]|-2.30|0.23|
|[[:human_genes:G:G3BP1|G3BP1]]|-2.29|0.33|
|[[:human_genes:G:GALNT11|GALNT11]]|-2.28|0.17|
|[[:human_genes:I:ITIH3|ITIH3]]|-2.27|0.33|
|[[:human_genes:M:METAP1|METAP1]]|2.33|0.18|
|[[:human_genes:L:LCE2A|LCE2A]]|2.37|0.16|
|[[:human_genes:Y:YTHDF1|YTHDF1]]|2.39|0.15|
|[[:human_genes:M:MOB4|MOB4]]|2.39|0.10|
|[[:human_genes:B:BICD2|BICD2]]|2.41|0.15|
|[[:human_genes:P:PALM2-AKAP2|PALM2-AKAP2]]|2.41|0.22|
|[[:human_genes:C:CLK2|CLK2]]|2.42|0.10|
|[[:human_genes:F:FMNL1|FMNL1]]|2.43|0.10|
|[[:human_genes:S:STRIP1|STRIP1]]|2.43|0.08|
|[[:human_genes:A:AIM1|AIM1]]|2.47|0.18|
|[[:human_genes:B:BCAP29|BCAP29]]|2.48|0.18|
|[[:human_genes:P:PHTF1|PHTF1]]|2.49|0.10|
|[[:human_genes:Z:ZCCHC9|ZCCHC9]]|2.49|0.12|
|[[:human_genes:C:CAMSAP1|CAMSAP1]]|2.50|0.27|
|[[:human_genes:P:PSMD3|PSMD3]]|2.51|0.27|
|[[:human_genes:T:TMEM161B|TMEM161B]]|2.53|0.09|
|[[:human_genes:T:TP53|TP53]]|2.53|0.10|
|[[:human_genes:S:SLC25A51|SLC25A51]]|2.56|0.06|
|[[:human_genes:M:MAPKAPK5|MAPKAPK5]]|2.57|0.10|
|[[:human_genes:Z:ZNF114|ZNF114]]|2.57|0.23|
|[[:human_genes:S:SLMAP|SLMAP]]|2.58|0.10|
|[[:human_genes:P:PLK1|PLK1]]|2.62|0.34|
|[[:human_genes:N:NOP2|NOP2]]|2.64|0.20|
|[[:human_genes:M:MYO9A|MYO9A]]|2.64|0.20|
|[[:human_genes:S:SLTM|SLTM]]|2.73|0.08|
|[[:human_genes:O:OTUD6B|OTUD6B]]|2.78|0.05|
|[[:human_genes:S:SPIRE2|SPIRE2]]|2.83|0.07|
|[[:human_genes:N:NCKAP1L|NCKAP1L]]|3.68|<0.01|
|[[:human_genes:A:AHCYL1|AHCYL1]]|4.57|<0.01|
|[[:human_genes:C:CLASP1|CLASP1]]|4.58|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|0.091|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|0.089|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.083|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|0.083|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|0.079|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|0.075|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|0.073|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.054|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|0.052|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|0.051|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|0.089|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|0.061|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.053|<button type="primary" size="small" modal="13">View</button>|
</modal>


<modal id="1" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  HMS-I1 1μM R01 exp46">
{{:chemogenomics:comparison_plots:exp45_vs_exp46.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Taxol 0.002μM R01 exp54">
{{:chemogenomics:comparison_plots:exp45_vs_exp54.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Taxol 0.004μM R03 exp103">
{{:chemogenomics:comparison_plots:exp103_vs_exp45.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Epothilone-B 0.0015μM R05 exp231">
{{:chemogenomics:comparison_plots:exp231_vs_exp45.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Ixabepilone 0.004 to 0.005μM on day4 R04 exp184">
{{:chemogenomics:comparison_plots:exp184_vs_exp45.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Vinblastine 0.002μM R01 exp60">
{{:chemogenomics:comparison_plots:exp45_vs_exp60.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Vincristine 0.0005μM R04 exp190">
{{:chemogenomics:comparison_plots:exp190_vs_exp45.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp45_vs_exp59.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  UM131593 0.1μM R01 exp58">
{{:chemogenomics:comparison_plots:exp45_vs_exp58.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Docetaxel 0.002μM R01 exp45  vs  Mdivi-1 15μM R05 exp217">
{{:chemogenomics:comparison_plots:exp217_vs_exp45.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Cabazitaxel 0.001μM R05 exp223  vs  Docetaxel 0.002μM R01 exp45">
{{:chemogenomics:comparison_plots:exp223_vs_exp45.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Docetaxel 0.001 to 0.002μM on day4 R04 exp159  vs  Docetaxel 0.002μM R01 exp45">
{{:chemogenomics:comparison_plots:exp159_vs_exp45.png?nolink |}}
</modal>

<modal id="13" size="lg" title="BML-284 0.09μM R08 exp460  vs  Docetaxel 0.002μM R01 exp45">
{{:chemogenomics:comparison_plots:exp45_vs_exp460.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|mitotic sister chromatid segregation|22.07|KIF18B,RHOA,KIF2A,KIF2C,DLGAP5|
|sister chromatid segregation|21.43|KIF18B,RHOA,KIF2A,KIF2C,DLGAP5|
|mitotic nuclear division|18.37|KIF18B,RHOA,KIF2A,KIF2C,DLGAP5|
|nuclear chromosome segregation|16.43|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,DLGAP5|
|microtubule binding|13.49|KIF18B,KIF2A,KATNA1,KIF2C,DLGAP5,GTSE1|
|chromosome organization|12.15|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,LIG4,DLGAP5,HASPIN,G3BP1|
|nuclear division|11.83|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,DLGAP5|
|ATP hydrolysis activity|10.64|KIF18B,KIF2A,ATP8B2,TRIP13,KATNA1,KIF2C,G3BP1|
|mitotic cell cycle process|10.39|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,DLGAP5,TACC3,HASPIN,GTSE1|
|spindle|10.02|KIF18B,KIF2A,KATNA1,KIF2C,DLGAP5,TACC3,HASPIN|
|cell division|9.44|KIF18B,RHOA,KIF2A,KATNA1,KIF2C,LIG4,TACC3,KLHL9|
|mitotic cell cycle|8.93|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,DLGAP5,TACC3,HASPIN,GTSE1|
|ATP-dependent activity|8.66|KIF18B,KIF2A,ATP8B2,TRIP13,TMEM30A,KATNA1,KIF2C,G3BP1|
|ribonucleoside triphosphate phosphatase activity|7.56|KIF18B,GNA13,RHOA,KIF2A,ATP8B2,TRIP13,KATNA1,KIF2C,G3BP1|
|pyrophosphatase activity|6.94|KIF18B,GNA13,RHOA,KIF2A,ATP8B2,TRIP13,KATNA1,KIF2C,G3BP1|
|hydrolase activity, acting on acid anhydrides|6.93|KIF18B,GNA13,RHOA,KIF2A,ATP8B2,TRIP13,KATNA1,KIF2C,G3BP1|
|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|6.93|KIF18B,GNA13,RHOA,KIF2A,ATP8B2,TRIP13,KATNA1,KIF2C,G3BP1|
|regulation of cell cycle process|6.89|RHOA,TRIP13,KIF2C,DLGAP5,TACC3,KLHL9,HASPIN,GTSE1|
|cell cycle process|6.14|KIF18B,RHOA,KIF2A,TRIP13,KIF2C,DLGAP5,TACC3,HASPIN,GTSE1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>