====== Benzoate 10000μM R08 exp455 ======
==== Mechanism of Action ====
Food additive (E211), bacteriostatic and fungistatic
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Food Preservative




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Sodium benzoate%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 532-32-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/517055|517055]]
    * **<color #00a2e8>IUPAC:</color>** %%sodium;benzoate%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C7H6O2.Na/c8-7(9)6-4-2-1-3-5-6;/h1-5H,(H,8,9);/q;+1/p-1
    * **<color #00a2e8>INCHI Key:</color>** WXMKPNITSTVMEF-UHFFFAOYSA-M
    * **<color #00a2e8>Molecular Weight:</color>** 144.1
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C(C=C1)C(=O)[O-].[Na+]
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C7H5O2Na
{{:chemogenomics:structures:chem-0266.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-Y1316
    * **<color #00a2e8>Lot #:</color>** 26735
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C7H6O2 145.026; found 145.02692
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Benzoate
    * **<color #00a2e8>Min:</color>** -0.6897; **<color #00a2e8>Max:</color>** 28.0815
{{:chemogenomics:dose_response:dr_503.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 10000µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.9
    * **<color #00a2e8>Numbers of reads</color>**: 13097136


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|14/4|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Benzoate_10000uM_Round-8_exp455.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Benzoate 10000μM R08 exp455'>
{{:chemogenomics:cranks_plots:exp455.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:R:RSRC2|RSRC2]]|-4.69|<0.01|
|[[:human_genes:C:CSK|CSK]]|-3.16|<0.01|
|[[:human_genes:M:MNS1|MNS1]]|-3.11|0.02|
|[[:human_genes:P:PAG1|PAG1]]|-2.90|0.02|
|[[:human_genes:M:MTF2|MTF2]]|-2.81|0.03|
|[[:human_genes:D:DERL2|DERL2]]|-2.76|0.03|
|[[:human_genes:U:UBE2J1|UBE2J1]]|-2.76|0.02|
|[[:human_genes:A:ARF1|ARF1]]|-2.62|0.03|
|[[:human_genes:L:LAMTOR4|LAMTOR4]]|-2.59|0.03|
|[[:human_genes:O:OPA1|OPA1]]|-2.57|0.04|
|[[:human_genes:S:SEPSECS|SEPSECS]]|-2.53|0.05|
|[[:human_genes:G:GCLM|GCLM]]|-2.53|0.03|
|[[:human_genes:H:HSD17B10|HSD17B10]]|-2.52|0.05|
|[[:human_genes:G:GCLC|GCLC]]|-2.49|0.03|
|[[:human_genes:S:SLC7A11|SLC7A11]]|-2.49|0.03|
|[[:human_genes:C:CARM1|CARM1]]|-2.48|0.03|
|[[:human_genes:S:SHISA8|SHISA8]]|-2.34|0.10|
|[[:human_genes:C:CSDE1|CSDE1]]|-2.31|0.06|
|[[:human_genes:B:BCL2|BCL2]]|-2.31|0.06|
|[[:human_genes:S:SMG7|SMG7]]|-2.28|0.12|
|[[:human_genes:S:SEC31A|SEC31A]]|-2.22|0.10|
|[[:human_genes:P:PDCD10|PDCD10]]|-2.22|0.10|
|[[:human_genes:N:NID1|NID1]]|-2.21|0.10|
|[[:human_genes:B:BACH2|BACH2]]|-2.17|0.20|
|[[:human_genes:D:DNAJC3|DNAJC3]]|-2.16|0.12|
|[[:human_genes:T:TCF4|TCF4]]|-2.13|0.13|
|[[:human_genes:T:TSC1|TSC1]]|-2.08|0.25|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-2.06|0.27|
|[[:human_genes:V:VPS52|VPS52]]|-2.06|0.54|
|[[:human_genes:N:NDUFA2|NDUFA2]]|-2.02|0.30|
|[[:human_genes:G:G6PD|G6PD]]|2.04|0.24|
|[[:human_genes:S:SRM|SRM]]|2.06|0.24|
|[[:human_genes:K:KANSL3|KANSL3]]|2.08|0.24|
|[[:human_genes:I:IPO13|IPO13]]|2.10|0.34|
|[[:human_genes:S:SF3A2|SF3A2]]|2.14|0.24|
|[[:human_genes:H:HDAC7|HDAC7]]|2.15|0.17|
|[[:human_genes:M:MFAP1|MFAP1]]|2.16|0.24|
|[[:human_genes:N:NCBP1|NCBP1]]|2.17|0.38|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.17|0.17|
|[[:human_genes:S:SBNO2|SBNO2]]|2.20|0.24|
|[[:human_genes:E:EXOSC6|EXOSC6]]|2.21|0.36|
|[[:human_genes:G:GGT7|GGT7]]|2.22|0.17|
|[[:human_genes:R:RPL11|RPL11]]|2.24|0.40|
|[[:human_genes:N:NOL9|NOL9]]|2.24|0.25|
|[[:human_genes:R:R3HDM1|R3HDM1]]|2.26|0.15|
|[[:human_genes:D:DYSF|DYSF]]|2.28|0.17|
|[[:human_genes:F:FAM98B|FAM98B]]|2.28|0.17|
|[[:human_genes:M:MARCH5|MARCH5]]|2.29|0.17|
|[[:human_genes:B:BAK1|BAK1]]|2.30|0.13|
|[[:human_genes:H:HSPA13|HSPA13]]|2.42|0.10|
|[[:human_genes:S:SHMT2|SHMT2]]|2.43|0.17|
|[[:human_genes:C:CD19|CD19]]|2.48|0.11|
|[[:human_genes:Z:ZCCHC8|ZCCHC8]]|2.53|0.10|
|[[:human_genes:R:RBM26|RBM26]]|2.56|0.10|
|[[:human_genes:Z:ZBTB7A|ZBTB7A]]|2.62|0.05|
|[[:human_genes:H:HEXIM1|HEXIM1]]|2.65|0.05|
|[[:human_genes:M:MTRNR2L4|MTRNR2L4]]|2.68|0.46|
|[[:human_genes:A:ARID4B|ARID4B]]|2.74|0.05|
|[[:human_genes:S:SLC25A1|SLC25A1]]|2.99|<0.01|
|[[:human_genes:R:RHOH|RHOH]]|3.56|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.082|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.062|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.059|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.057|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.052|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|0.051|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.064|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|0.056|<button type="primary" size="small" modal="8">View</button>|
</modal>


<modal id="1" size="lg" title="Benzoate 10000μM R08 exp455  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp234_vs_exp455.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Benzoate 10000μM R08 exp455  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp407_vs_exp455.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Benzoate 10000μM R08 exp455  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp455.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Benzoate 10000μM R08 exp455  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp455_vs_exp525.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Benzoate 10000μM R08 exp455  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp455_vs_exp526.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Benzoate 10000μM R08 exp455  vs  ETC-159 50μM R08 exp480">
{{:chemogenomics:comparison_plots:exp455_vs_exp480.png?nolink |}}
</modal>

<modal id="7" size="lg" title="B02 10μM R08 exp453  vs  Benzoate 10000μM R08 exp455">
{{:chemogenomics:comparison_plots:exp453_vs_exp455.png?nolink |}}
</modal>

<modal id="8" size="lg" title="5-Azacytidine 2μM R07 exp330  vs  Benzoate 10000μM R08 exp455">
{{:chemogenomics:comparison_plots:exp330_vs_exp455.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|regulation of mitochondrial depolarization|104.43|GCLM,GCLC,BCL2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>