====== Bleomycin 5μM R08 exp459 ======
==== Mechanism of Action ====
Induces DNA strand breaks, possibly by iron chelation and ROS generation, or generation of alkali-labile lesions
* **Class / Subclass 1:** DNA Damage, Repair and Replication / Clastogen
==== Technical Notes ====
* **PubChem Name:** %%Bleomycin sulfate%%
* **Synonyms:** N/A
* **CAS #:** 9041-93-4
* **PubChem CID:** [[https://pubchem.ncbi.nlm.nih.gov/compound/72466|72466]]
* **IUPAC:** %%3-[[2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium;hydrogen sulfate%%
* **INCHI Name:** InChI=1S/C55H83N17O21S3.H2O4S/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t21?,22?,23?,24?,25?,29-,30+,34?,35?,36?,37+,38+,39-,40-,41?,42-,43-,53+,54-;/m0./s1
* **INCHI Key:** WUIABRMSWOKTOF-OCBSMOPSSA-N
* **Molecular Weight:** 1512.6
* **Canonical SMILES:** CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
* **Isomeric SMILES:** CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
* **Molecular Formula:** C55H85N17O25S4
{{:chemogenomics:structures:chem-0269.svg?nolink}}
* **Supplier Name:** Med Chem Express
* **Catalog #:** HY-17565
* **Lot #:** 27306
* **HRMS (ESI-TOF) m/z:** (M)+ Calcd for C55H84N17O21S3 1414.51898; found 1414.51692
* **Platform ID:** Bleomycin
* **Min:** -9.4082; **Max:** 78.5072
{{:chemogenomics:dose_response:dr_505.png?nolink&500 |}}
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^ IC ^ Concentration (µM) ^
| IC10 |0.8983 |
| IC20 |1.7420 |
| IC30 |2.7040 |
| IC40 |3.8790 |
| IC50 |5.4010 |
| IC60 |7.5210 |
| IC70 |10.7900 |
| IC80 |16.7500 |
| IC90 |32.4800 |
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==== Screen Summary ====
* **Round**: 08
* **Dose**: 5µM
* **Days of incubation**: 8
* **Doublings**: -0.2
* **Numbers of reads**: 14879101
==== Screen Results ====
^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/57|[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Bleomycin_5uM_Round-8_exp459.txt|Scores]]||||||
{{:chemogenomics:cranks_plots:exp459.png?nolink}}
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SMG1|SMG1]]|-2.89|0.06|
|[[:human_genes:Z:ZFYVE20|ZFYVE20]]|-2.79|0.13|
|[[:human_genes:G:GPX4|GPX4]]|-2.71|0.06|
|[[:human_genes:U:UBE4B|UBE4B]]|-2.65|0.06|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.61|0.26|
|[[:human_genes:M:MUL1|MUL1]]|-2.52|0.13|
|[[:human_genes:O:OSBP|OSBP]]|-2.50|0.13|
|[[:human_genes:P:PSMD14|PSMD14]]|-2.46|0.54|
|[[:human_genes:M:MTCH2|MTCH2]]|-2.45|0.24|
|[[:human_genes:P:PRMT1|PRMT1]]|-2.34|0.34|
|[[:human_genes:Z:ZNF880|ZNF880]]|-2.34|0.13|
|[[:human_genes:Q:QSER1|QSER1]]|-2.33|0.13|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-2.32|0.13|
|[[:human_genes:M:MDM2|MDM2]]|-2.29|0.31|
|[[:human_genes:D:DDX21|DDX21]]|-2.29|0.54|
|[[:human_genes:E:EXOSC4|EXOSC4]]|-2.27|0.31|
|[[:human_genes:H:HPS4|HPS4]]|-2.22|0.21|
|[[:human_genes:D:DNM2|DNM2]]|-2.21|0.54|
|[[:human_genes:N:NRL|NRL]]|-2.20|0.21|
|[[:human_genes:A:ABRA|ABRA]]|-2.12|0.31|
|[[:human_genes:T:TMEM202|TMEM202]]|-2.12|0.26|
|[[:human_genes:C:CPSF2|CPSF2]]|-2.09|0.54|
|[[:human_genes:T:TP53BP2|TP53BP2]]|-2.07|0.31|
|[[:human_genes:R:RND1|RND1]]|-2.07|0.31|
|[[:human_genes:P:PSMD1|PSMD1]]|-2.06|0.47|
|[[:human_genes:T:TMEM174|TMEM174]]|-2.04|0.34|
|[[:human_genes:A:ATXN1|ATXN1]]|-2.03|0.54|
|[[:human_genes:B:BRIX1|BRIX1]]|-2.02|0.35|
|[[:human_genes:P:PSMD6|PSMD6]]|-2.02|0.54|
|[[:human_genes:R:RBM7|RBM7]]|-2.02|0.51|
|[[:human_genes:M:METAP2|METAP2]]|2.61|0.03|
|[[:human_genes:S:SLC4A7|SLC4A7]]|2.62|0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|2.62|<0.01|
|[[:human_genes:H:HSPD1|HSPD1]]|2.66|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|2.74|<0.01|
|[[:human_genes:A:ATP5A1|ATP5A1]]|2.74|0.02|
|[[:human_genes:K:KCTD5|KCTD5]]|2.76|<0.01|
|[[:human_genes:R:RABIF|RABIF]]|2.77|<0.01|
|[[:human_genes:M:METAP1|METAP1]]|2.83|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|2.83|<0.01|
|[[:human_genes:T:TRIAP1|TRIAP1]]|2.85|0.01|
|[[:human_genes:T:THG1L|THG1L]]|2.86|<0.01|
|[[:human_genes:R:RHOA|RHOA]]|2.88|<0.01|
|[[:human_genes:T:TP53|TP53]]|2.92|<0.01|
|[[:human_genes:T:TLE4|TLE4]]|3.04|<0.01|
|[[:human_genes:D:DOHH|DOHH]]|3.15|<0.01|
|[[:human_genes:S:SPOP|SPOP]]|3.21|0.00|
|[[:human_genes:E:EXOC2|EXOC2]]|3.24|0.00|
|[[:human_genes:R:RPTOR|RPTOR]]|3.41|0.00|
|[[:human_genes:R:RIC8A|RIC8A]]|3.44|0.00|
|[[:human_genes:E:ENY2|ENY2]]|3.62|0.00|
|[[:human_genes:M:MED16|MED16]]|3.65|0.00|
|[[:human_genes:G:GMPPB|GMPPB]]|3.67|0.01|
|[[:human_genes:F:FAF2|FAF2]]|3.81|0.00|
|[[:human_genes:U:UBQLN1|UBQLN1]]|4.09|0.00|
|[[:human_genes:G:GNA13|GNA13]]|4.38|0.00|
|[[:human_genes:P:PLAA|PLAA]]|4.40|0.00|
|[[:human_genes:A:ATP2B1|ATP2B1]]|4.75|0.00|
|[[:human_genes:B:BAK1|BAK1]]|6.61|0.00|
|[[:human_genes:G:GJC1|GJC1]]|7.08|0.00|
^Screen^Correlation^Plot^
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.152||
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.15||
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.15||
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.142||
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.127||
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.121||
|[[:results:exp135|MS023 7μM R03 exp135]]|0.119||
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.119||
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.115||
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.105||
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.1||
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.099||
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.096||
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.095||
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.092||
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.09||
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.087||
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.083||
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.08||
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.075||
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.074||
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.071||
|[[:results:exp134|MS023 2μM R03 exp134]]|0.071||
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.07||
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.068||
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.064||
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.063||
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.061||
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.061||
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.057||
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.055||
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.052||
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.166||
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.119||
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.115||
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.11||
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.109||
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.1||
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.085||
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.079||
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.079||
|[[:results:exp539|42°C R08 exp539]]|0.067||
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.065||
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.063||
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.055||
{{:chemogenomics:comparison_plots:exp459_vs_exp478.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp503.png?nolink |}}
{{:chemogenomics:comparison_plots:exp199_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp531.png?nolink |}}
{{:chemogenomics:comparison_plots:exp443_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp28_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp135_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp472.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp524.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp80.png?nolink |}}
{{:chemogenomics:comparison_plots:exp19_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp34_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp527.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp515.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp489.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp512.png?nolink |}}
{{:chemogenomics:comparison_plots:exp126_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp488.png?nolink |}}
{{:chemogenomics:comparison_plots:exp106_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp85.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp474.png?nolink |}}
{{:chemogenomics:comparison_plots:exp435_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp134_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp357_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp22_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp485.png?nolink |}}
{{:chemogenomics:comparison_plots:exp355_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp468.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp529.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp502.png?nolink |}}
{{:chemogenomics:comparison_plots:exp108_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp500.png?nolink |}}
{{:chemogenomics:comparison_plots:exp456_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp3_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp2_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp451_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp259_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp440_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp448_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp211_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp450_vs_exp459.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp539.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp98.png?nolink |}}
{{:chemogenomics:comparison_plots:exp459_vs_exp96.png?nolink |}}
{{:chemogenomics:comparison_plots:exp116_vs_exp459.png?nolink |}}
No GO term hits below threshold. (FDR <0.05)
No GO term hits below threshold. (FDR <0.05)