====== Cannabidiol 13μM R08 exp465 ======
==== Mechanism of Action ====
Negative allosteric modulator of cannabinoid CB1 receptor
  * **<color #00a2e8>Class / Subclass 1:</color>** Environmental Stresses / Psychoactive Drug
  * **<color #00a2e8>Class / Subclass 2:</color>** Signal Transduction / GPCR Antagonist



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Cannabidiol%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 13956-29-1
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/644019|644019]]
    * **<color #00a2e8>IUPAC:</color>** %%2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
    * **<color #00a2e8>INCHI Key:</color>** QHMBSVQNZZTUGM-ZWKOTPCHSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 314.5
    * **<color #00a2e8>Canonical SMILES:</color>** CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O
    * **<color #00a2e8>Isomeric SMILES:</color>** CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O
    * **<color #00a2e8>Molecular Formula:</color>** C21H30O2
{{:chemogenomics:structures:chem-0275.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** C175300
    * **<color #00a2e8>Lot #:</color>** 9-RIT-154-2
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 1.38 min, m/z 315+ [M+H]+, 313- [M-H]-
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** CBD
    * **<color #00a2e8>Min:</color>** -4.3129; **<color #00a2e8>Max:</color>** 99.8419
{{:chemogenomics:dose_response:dr_606.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |7.8520    |
| IC20  |10.4800    |
| IC30  |12.6900    |
| IC40  |14.8500    |
| IC50  |17.1600    |
| IC60  |19.8200    |
| IC70  |23.1900    |
| IC80  |28.0900    |
| IC90  |37.4800    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 13µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.1
    * **<color #00a2e8>Numbers of reads</color>**: 14029650


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|12/5|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Cannabidiol_13uM_Round-8_exp465.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Cannabidiol 13μM R08 exp465'>
{{:chemogenomics:cranks_plots:exp465.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:S:SLC5A3|SLC5A3]]|-4.09|<0.01|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.72|<0.01|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-3.01|<0.01|
|[[:human_genes:G:GOT1|GOT1]]|-2.99|<0.01|
|[[:human_genes:W:WDR44|WDR44]]|-2.78|0.04|
|[[:human_genes:Q:QARS|QARS]]|-2.69|0.38|
|[[:human_genes:D:DERL1|DERL1]]|-2.62|0.04|
|[[:human_genes:P:PRKAA1|PRKAA1]]|-2.58|0.04|
|[[:human_genes:A:ASTE1|ASTE1]]|-2.54|0.04|
|[[:human_genes:S:SLC39A10|SLC39A10]]|-2.54|0.04|
|[[:human_genes:J:JTB|JTB]]|-2.52|0.04|
|[[:human_genes:A:ATP2A2|ATP2A2]]|-2.51|0.64|
|[[:human_genes:Z:ZNF730|ZNF730]]|-2.48|0.07|
|[[:human_genes:A:ARL1|ARL1]]|-2.47|0.04|
|[[:human_genes:S:SH3KBP1|SH3KBP1]]|-2.46|0.04|
|[[:human_genes:G:GPR107|GPR107]]|-2.37|0.07|
|[[:human_genes:C:C18orf32|C18orf32]]|-2.30|0.59|
|[[:human_genes:G:GMPPB|GMPPB]]|-2.28|0.61|
|[[:human_genes:L:LRP1B|LRP1B]]|-2.23|0.12|
|[[:human_genes:Z:ZNF395|ZNF395]]|-2.23|0.17|
|[[:human_genes:K:KAT7|KAT7]]|-2.22|0.12|
|[[:human_genes:V:VMA21|VMA21]]|-2.22|0.12|
|[[:human_genes:T:TMEM30A|TMEM30A]]|-2.17|0.15|
|[[:human_genes:R:RER1|RER1]]|-2.14|0.16|
|[[:human_genes:K:KDSR|KDSR]]|-2.14|0.16|
|[[:human_genes:O:OR5F1|OR5F1]]|-2.12|0.36|
|[[:human_genes:R:RCE1|RCE1]]|-2.12|0.17|
|[[:human_genes:C:CHMP6|CHMP6]]|-2.10|0.28|
|[[:human_genes:V:VPS35|VPS35]]|-2.10|0.17|
|[[:human_genes:U:UGT1A9|UGT1A9]]|-2.08|0.19|
|[[:human_genes:A:ATP5C1|ATP5C1]]|2.00|0.30|
|[[:human_genes:C:COX4I1|COX4I1]]|2.00|0.49|
|[[:human_genes:C:CCDC179|CCDC179]]|2.02|0.29|
|[[:human_genes:C:C19orf33|C19orf33]]|2.03|0.28|
|[[:human_genes:S:SH3GLB1|SH3GLB1]]|2.04|0.28|
|[[:human_genes:T:TMEM242|TMEM242]]|2.07|0.26|
|[[:human_genes:D:DCST2|DCST2]]|2.09|0.26|
|[[:human_genes:F:FOXRED1|FOXRED1]]|2.09|0.30|
|[[:human_genes:C:CXorf56|CXorf56]]|2.11|0.30|
|[[:human_genes:N:NDUFS8|NDUFS8]]|2.11|0.25|
|[[:human_genes:E:EIF1|EIF1]]|2.13|0.39|
|[[:human_genes:S:SHMT2|SHMT2]]|2.13|0.39|
|[[:human_genes:S:SON|SON]]|2.14|0.23|
|[[:human_genes:R:RAB5C|RAB5C]]|2.14|0.23|
|[[:human_genes:H:HEATR5B|HEATR5B]]|2.15|0.23|
|[[:human_genes:P:PPP1R21|PPP1R21]]|2.16|0.23|
|[[:human_genes:M:MYRF|MYRF]]|2.18|0.27|
|[[:human_genes:Z:ZNF224|ZNF224]]|2.18|0.23|
|[[:human_genes:P:PARP2|PARP2]]|2.21|0.26|
|[[:human_genes:S:SRSF7|SRSF7]]|2.29|0.23|
|[[:human_genes:F:FAM98B|FAM98B]]|2.29|0.23|
|[[:human_genes:P:POLE|POLE]]|2.36|0.43|
|[[:human_genes:D:DNAH17|DNAH17]]|2.38|0.23|
|[[:human_genes:O:OR2AE1|OR2AE1]]|2.61|0.04|
|[[:human_genes:L:LIPT2|LIPT2]]|2.61|0.20|
|[[:human_genes:S:SLC25A19|SLC25A19]]|2.62|0.04|
|[[:human_genes:S:SARS|SARS]]|2.74|0.49|
|[[:human_genes:P:PTAR1|PTAR1]]|2.98|0.02|
|[[:human_genes:P:PPP6C|PPP6C]]|3.13|<0.01|
|[[:human_genes:D:DLD|DLD]]|3.66|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|0.087|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|0.074|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.072|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.07|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp149|SB203580 25μM R03 exp149]]|0.068|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|0.065|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.062|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|0.061|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.056|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|0.056|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.078|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|0.063|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|0.061|<button type="primary" size="small" modal="13">View</button>|
</modal>


<modal id="1" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Cannabidiol 20μM R08 exp466">
{{:chemogenomics:comparison_plots:exp465_vs_exp466.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Prochlorperazine 5.2μM R02 exp77">
{{:chemogenomics:comparison_plots:exp465_vs_exp77.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Chlorpromazine 10μM R07 exp344">
{{:chemogenomics:comparison_plots:exp344_vs_exp465.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp465_vs_exp530.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Cannabidiol 13μM R08 exp465  vs  SB203580 25μM R03 exp149">
{{:chemogenomics:comparison_plots:exp149_vs_exp465.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Cannabidiol 13μM R08 exp465  vs  EPZ-5676 30μM R05 exp233">
{{:chemogenomics:comparison_plots:exp233_vs_exp465.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Cannabidiol 13μM R08 exp465  vs  ∆-9-Tetrahydrocannabinol 30μM R08 exp445">
{{:chemogenomics:comparison_plots:exp445_vs_exp465.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Hydroxychloroquine 30μM R08 exp490">
{{:chemogenomics:comparison_plots:exp465_vs_exp490.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Cannabidiol 13μM R08 exp465  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp465_vs_exp508.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Cannabidiol 13μM R08 exp465  vs  Cryptotanshinone 12μM R05 exp227">
{{:chemogenomics:comparison_plots:exp227_vs_exp465.png?nolink |}}
</modal>

<modal id="11" size="lg" title="BS-181 20μM R08 exp461  vs  Cannabidiol 13μM R08 exp465">
{{:chemogenomics:comparison_plots:exp461_vs_exp465.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Bisphenol A 100μM R06 exp269  vs  Cannabidiol 13μM R08 exp465">
{{:chemogenomics:comparison_plots:exp269_vs_exp465.png?nolink |}}
</modal>

<modal id="13" size="lg" title="CCT251545 20μM R07 exp326  vs  Cannabidiol 13μM R08 exp465">
{{:chemogenomics:comparison_plots:exp326_vs_exp465.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>