====== GSK626616 14μM R08 exp485 ======
==== Mechanism of Action ====
Inhibits DYRK3, prevents stress granule dissolution, mTORC1 release
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%4(5H)-Thiazolone, 2-((2,6-dichlorophenyl)amino)-5-(6-quinoxalinylmethylene)-, (5Z)-%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1025821-33-3
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/135416229|135416229]]
    * **<color #00a2e8>IUPAC:</color>** %%(5Z)-2-(2,6-dichlorophenyl)imino-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidin-4-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
    * **<color #00a2e8>INCHI Key:</color>** RJPNRXFBYZVRIB-DHDCSXOGSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 401.3
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=C(C(=C1)Cl)N=C2NC(=O)C(=CC3=CC4=NC=CN=C4C=C3)S2)Cl
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=C(C(=C1)Cl)N=C2NC(=O)/C(=C/C3=CC4=NC=CN=C4C=C3)/S2)Cl
    * **<color #00a2e8>Molecular Formula:</color>** C18H10Cl2N4OS
{{:chemogenomics:structures:chem-0294.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Tocris Bioscience
    * **<color #00a2e8>Catalog #:</color>** 6638
    * **<color #00a2e8>Lot #:</color>** 1A/216989
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C18H10Cl2N4OS 401.00251; found 401.00255
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** GSK626616
    * **<color #00a2e8>Min:</color>** -3.2829; **<color #00a2e8>Max:</color>** 99.0208
{{:chemogenomics:dose_response:dr_539.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |8.4010    |
| IC20  |11.1700    |
| IC30  |13.4900    |
| IC40  |15.7500    |
| IC50  |18.1600    |
| IC60  |20.9400    |
| IC70  |24.4500    |
| IC80  |29.5400    |
| IC90  |39.2700    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 14µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.9
    * **<color #00a2e8>Numbers of reads</color>**: 16240671


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|22/93|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/GSK626616_14uM_Round-8_exp485.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='GSK626616 14μM R08 exp485'>
{{:chemogenomics:cranks_plots:exp485.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:C:CLK3|CLK3]]|-5.35|<0.01|
|[[:human_genes:T:TCF4|TCF4]]|-3.48|<0.01|
|[[:human_genes:S:STMN1|STMN1]]|-3.38|<0.01|
|[[:human_genes:B:BRD1|BRD1]]|-3.10|<0.01|
|[[:human_genes:N:NRAS|NRAS]]|-2.98|<0.01|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.93|<0.01|
|[[:human_genes:P:PDS5B|PDS5B]]|-2.87|<0.01|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.87|<0.01|
|[[:human_genes:Z:ZBTB10|ZBTB10]]|-2.79|<0.01|
|[[:human_genes:F:FTO|FTO]]|-2.77|<0.01|
|[[:human_genes:S:SNRPD1|SNRPD1]]|-2.74|0.07|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.74|0.02|
|[[:human_genes:G:GAK|GAK]]|-2.73|<0.01|
|[[:human_genes:S:STYX|STYX]]|-2.70|0.02|
|[[:human_genes:K:KIF18A|KIF18A]]|-2.65|0.01|
|[[:human_genes:S:SRPK1|SRPK1]]|-2.58|0.02|
|[[:human_genes:C:CLK1|CLK1]]|-2.53|0.02|
|[[:human_genes:K:KAT7|KAT7]]|-2.51|0.02|
|[[:human_genes:C:C9orf41|C9orf41]]|-2.51|0.07|
|[[:human_genes:T:TRIM44|TRIM44]]|-2.50|0.04|
|[[:human_genes:D:DCAF15|DCAF15]]|-2.49|0.04|
|[[:human_genes:R:RNF4|RNF4]]|-2.48|0.04|
|[[:human_genes:X:XPO6|XPO6]]|-2.35|0.04|
|[[:human_genes:S:SKA1|SKA1]]|-2.34|0.04|
|[[:human_genes:F:FZR1|FZR1]]|-2.32|0.08|
|[[:human_genes:C:C1orf21|C1orf21]]|-2.29|0.06|
|[[:human_genes:R:RBM12|RBM12]]|-2.28|0.06|
|[[:human_genes:N:NSMCE1|NSMCE1]]|-2.26|0.06|
|[[:human_genes:W:WAPAL|WAPAL]]|-2.26|0.10|
|[[:human_genes:S:SHOC2|SHOC2]]|-2.24|0.10|
|[[:human_genes:I:IKZF2|IKZF2]]|3.46|0.00|
|[[:human_genes:P:PCIF1|PCIF1]]|3.48|0.00|
|[[:human_genes:R:RMND5A|RMND5A]]|3.49|0.00|
|[[:human_genes:P:PLAA|PLAA]]|3.62|0.00|
|[[:human_genes:T:TSC2|TSC2]]|3.62|0.00|
|[[:human_genes:E:ELF2|ELF2]]|3.69|0.00|
|[[:human_genes:R:RPL5|RPL5]]|3.69|0.00|
|[[:human_genes:C:CDK2|CDK2]]|3.79|0.00|
|[[:human_genes:A:APAF1|APAF1]]|3.81|0.00|
|[[:human_genes:G:GPATCH8|GPATCH8]]|3.84|0.00|
|[[:human_genes:U:UBQLN1|UBQLN1]]|4.00|0.00|
|[[:human_genes:G:GID8|GID8]]|4.19|0.00|
|[[:human_genes:S:SMEK1|SMEK1]]|4.35|0.00|
|[[:human_genes:M:MAEA|MAEA]]|4.38|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|4.39|0.00|
|[[:human_genes:F:FAM58A|FAM58A]]|4.40|0.00|
|[[:human_genes:E:EIF2AK4|EIF2AK4]]|4.53|0.00|
|[[:human_genes:D:DEPDC5|DEPDC5]]|4.56|0.00|
|[[:human_genes:H:HEATR3|HEATR3]]|4.61|0.00|
|[[:human_genes:R:RPL22|RPL22]]|4.67|0.00|
|[[:human_genes:R:RBM26|RBM26]]|4.75|0.00|
|[[:human_genes:N:NPRL2|NPRL2]]|4.82|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|5.05|0.00|
|[[:human_genes:Y:YLPM1|YLPM1]]|5.53|0.00|
|[[:human_genes:N:NPRL3|NPRL3]]|5.56|0.00|
|[[:human_genes:R:RPL11|RPL11]]|5.91|0.00|
|[[:human_genes:B:BAK1|BAK1]]|5.93|0.00|
|[[:human_genes:D:DDX3X|DDX3X]]|6.48|0.00|
|[[:human_genes:E:EIF4A1|EIF4A1]]|7.54|0.00|
|[[:human_genes:T:TP53|TP53]]|7.60|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.104|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.101|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.096|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.092|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.092|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.089|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.087|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp504|MK2206 4μM R08 exp504]]|0.084|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.082|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.08|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.073|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.07|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.069|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.068|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.068|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.068|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.067|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.066|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.064|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|0.063|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.062|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.061|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|0.061|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.061|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.061|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|0.06|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.058|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.055|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.055|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|0.055|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|0.054|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|0.054|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp210|LB-100 2μM R05 exp210]]|0.052|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.051|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.12|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.118|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.101|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.089|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.087|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.087|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.08|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.079|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.079|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|0.075|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.069|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.067|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.065|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.064|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.063|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|0.062|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.062|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.061|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|0.061|<button type="primary" size="small" modal="53">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.056|<button type="primary" size="small" modal="54">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.056|<button type="primary" size="small" modal="55">View</button>|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|0.055|<button type="primary" size="small" modal="56">View</button>|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|0.055|<button type="primary" size="small" modal="57">View</button>|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|0.054|<button type="primary" size="small" modal="58">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.053|<button type="primary" size="small" modal="59">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.051|<button type="primary" size="small" modal="60">View</button>|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|0.051|<button type="primary" size="small" modal="61">View</button>|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.051|<button type="primary" size="small" modal="62">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.051|<button type="primary" size="small" modal="63">View</button>|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|0.051|<button type="primary" size="small" modal="64">View</button>|
</modal>


<modal id="1" size="lg" title="GSK626616 14μM R08 exp485  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp485_vs_exp489.png?nolink |}}
</modal>

<modal id="2" size="lg" title="GSK626616 14μM R08 exp485  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp485_vs_exp524.png?nolink |}}
</modal>

<modal id="3" size="lg" title="GSK626616 14μM R08 exp485  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp485_vs_exp488.png?nolink |}}
</modal>

<modal id="4" size="lg" title="GSK626616 14μM R08 exp485  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp485_vs_exp512.png?nolink |}}
</modal>

<modal id="5" size="lg" title="GSK626616 14μM R08 exp485  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp485.png?nolink |}}
</modal>

<modal id="6" size="lg" title="GSK626616 14μM R08 exp485  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp485_vs_exp80.png?nolink |}}
</modal>

<modal id="7" size="lg" title="GSK626616 14μM R08 exp485  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp485_vs_exp503.png?nolink |}}
</modal>

<modal id="8" size="lg" title="GSK626616 14μM R08 exp485  vs  MK2206 4μM R08 exp504">
{{:chemogenomics:comparison_plots:exp485_vs_exp504.png?nolink |}}
</modal>

<modal id="9" size="lg" title="GSK626616 14μM R08 exp485  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp407_vs_exp485.png?nolink |}}
</modal>

<modal id="10" size="lg" title="GSK626616 14μM R08 exp485  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp485_vs_exp529.png?nolink |}}
</modal>

<modal id="11" size="lg" title="GSK626616 14μM R08 exp485  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp485_vs_exp517.png?nolink |}}
</modal>

<modal id="12" size="lg" title="GSK626616 14μM R08 exp485  vs  Lead acetate 2000μM R08 exp498 no dilution day6">
{{:chemogenomics:comparison_plots:exp485_vs_exp498.png?nolink |}}
</modal>

<modal id="13" size="lg" title="GSK626616 14μM R08 exp485  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp485_vs_exp85.png?nolink |}}
</modal>

<modal id="14" size="lg" title="GSK626616 14μM R08 exp485  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp485.png?nolink |}}
</modal>

<modal id="15" size="lg" title="GSK626616 14μM R08 exp485  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp374_vs_exp485.png?nolink |}}
</modal>

<modal id="16" size="lg" title="GSK626616 14μM R08 exp485  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp485_vs_exp502.png?nolink |}}
</modal>

<modal id="17" size="lg" title="GSK626616 14μM R08 exp485  vs  Lead acetate 2000μM R08 exp497">
{{:chemogenomics:comparison_plots:exp485_vs_exp497.png?nolink |}}
</modal>

<modal id="18" size="lg" title="GSK626616 14μM R08 exp485  vs  ML-792 0.2μM R08 exp505">
{{:chemogenomics:comparison_plots:exp485_vs_exp505.png?nolink |}}
</modal>

<modal id="19" size="lg" title="GSK626616 14μM R08 exp485  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp485.png?nolink |}}
</modal>

<modal id="20" size="lg" title="GSK626616 14μM R08 exp485  vs  I-BRD9 4μM R07 exp365">
{{:chemogenomics:comparison_plots:exp365_vs_exp485.png?nolink |}}
</modal>

<modal id="21" size="lg" title="GSK626616 14μM R08 exp485  vs  Tozasertib 0.1μM R07 exp414">
{{:chemogenomics:comparison_plots:exp414_vs_exp485.png?nolink |}}
</modal>

<modal id="22" size="lg" title="GSK626616 14μM R08 exp485  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp485_vs_exp531.png?nolink |}}
</modal>

<modal id="23" size="lg" title="GSK626616 14μM R08 exp485  vs  Wortmannin 5μM R00 exp38">
{{:chemogenomics:comparison_plots:exp38_vs_exp485.png?nolink |}}
</modal>

<modal id="24" size="lg" title="GSK626616 14μM R08 exp485  vs  Nutlin-3A 1.6μM R06 exp294">
{{:chemogenomics:comparison_plots:exp294_vs_exp485.png?nolink |}}
</modal>

<modal id="25" size="lg" title="GSK626616 14μM R08 exp485  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp485_vs_exp525.png?nolink |}}
</modal>

<modal id="26" size="lg" title="GSK626616 14μM R08 exp485  vs  TRAIL 5ng/ml R00 exp35">
{{:chemogenomics:comparison_plots:exp35_vs_exp485.png?nolink |}}
</modal>

<modal id="27" size="lg" title="GSK626616 14μM R08 exp485  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp485.png?nolink |}}
</modal>

<modal id="28" size="lg" title="GSK626616 14μM R08 exp485  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp435_vs_exp485.png?nolink |}}
</modal>

<modal id="29" size="lg" title="GSK626616 14μM R08 exp485  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp485.png?nolink |}}
</modal>

<modal id="30" size="lg" title="GSK626616 14μM R08 exp485  vs  Tubacin 1.6μM R07 exp416">
{{:chemogenomics:comparison_plots:exp416_vs_exp485.png?nolink |}}
</modal>

<modal id="31" size="lg" title="GSK626616 14μM R08 exp485  vs  Rapamycin 10μM R00 exp30">
{{:chemogenomics:comparison_plots:exp30_vs_exp485.png?nolink |}}
</modal>

<modal id="32" size="lg" title="GSK626616 14μM R08 exp485  vs  Rapamycin 2μM R07 exp306">
{{:chemogenomics:comparison_plots:exp306_vs_exp485.png?nolink |}}
</modal>

<modal id="33" size="lg" title="GSK626616 14μM R08 exp485  vs  LB-100 2μM R05 exp210">
{{:chemogenomics:comparison_plots:exp210_vs_exp485.png?nolink |}}
</modal>

<modal id="34" size="lg" title="GSK626616 14μM R08 exp485  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp485_vs_exp527.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp3_vs_exp485.png?nolink |}}
</modal>

<modal id="36" size="lg" title="AICAR 240μM R03 exp116  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp116_vs_exp485.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Benzoate 20000μM R08 exp456  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp456_vs_exp485.png?nolink |}}
</modal>

<modal id="38" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp357_vs_exp485.png?nolink |}}
</modal>

<modal id="39" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp2_vs_exp485.png?nolink |}}
</modal>

<modal id="40" size="lg" title="AICAR 240μM R05 exp211  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp211_vs_exp485.png?nolink |}}
</modal>

<modal id="41" size="lg" title="CR131-b 0.005μM R08 exp474  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp474_vs_exp485.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Etoposide 0.3μM R05 exp199  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp199_vs_exp485.png?nolink |}}
</modal>

<modal id="43" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp440_vs_exp485.png?nolink |}}
</modal>

<modal id="44" size="lg" title="Dexamethasone 0.006 to 0.015μM on day4 R07 exp352  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp352_vs_exp485.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Centrinone 0.5μM R07 exp343  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp343_vs_exp485.png?nolink |}}
</modal>

<modal id="46" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp355_vs_exp485.png?nolink |}}
</modal>

<modal id="47" size="lg" title="Ethanol 0.01 R05 exp234  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp234_vs_exp485.png?nolink |}}
</modal>

<modal id="48" size="lg" title="Bleomycin 5μM R08 exp459  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp459_vs_exp485.png?nolink |}}
</modal>

<modal id="49" size="lg" title="Arsenate 40μM R06 exp264  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp264_vs_exp485.png?nolink |}}
</modal>

<modal id="50" size="lg" title="Erlotinib 10μM R05 exp216  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp216_vs_exp485.png?nolink |}}
</modal>

<modal id="51" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp478_vs_exp485.png?nolink |}}
</modal>

<modal id="52" size="lg" title="CB-5083 0.4μM R08 exp468  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp468_vs_exp485.png?nolink |}}
</modal>

<modal id="53" size="lg" title="Cytochalasin-B 5μM R07 exp349  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp349_vs_exp485.png?nolink |}}
</modal>

<modal id="54" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp259_vs_exp485.png?nolink |}}
</modal>

<modal id="55" size="lg" title="BML-284 0.09μM R08 exp460  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp460_vs_exp485.png?nolink |}}
</modal>

<modal id="56" size="lg" title="Etoposide 0.1μM R05 exp198  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp198_vs_exp485.png?nolink |}}
</modal>

<modal id="57" size="lg" title="Demecolcine 0.03μM R05 exp228  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp228_vs_exp485.png?nolink |}}
</modal>

<modal id="58" size="lg" title="Azithromycin 100μM R08 exp452  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp452_vs_exp485.png?nolink |}}
</modal>

<modal id="59" size="lg" title="CI-1040 9.5μM R08 exp472  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp472_vs_exp485.png?nolink |}}
</modal>

<modal id="60" size="lg" title="Etoposide 1μM R00 exp19  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp19_vs_exp485.png?nolink |}}
</modal>

<modal id="61" size="lg" title="BI-D1870 3.15μM R02 exp66  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp485_vs_exp66.png?nolink |}}
</modal>

<modal id="62" size="lg" title="Combretastatin A4 0.002 to 0.003μM day4 R04 exp179  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp179_vs_exp485.png?nolink |}}
</modal>

<modal id="63" size="lg" title="CAY10603 0.55μM R08 exp467  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp467_vs_exp485.png?nolink |}}
</modal>

<modal id="64" size="lg" title="GSK-J4 1-1.25μM to day4 R07 exp363  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp363_vs_exp485.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|chromosomal region|11.52|PDS5B,ZBTB10,KIF18A,KAT7,SKA1,NSMCE1,WAPL|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|GATOR1 complex|552.30|NPRL3,NPRL2|
|negative regulation of protein neddylation|368.20|RPL11,RPL5|
|Seh1-associated complex|236.70|NPRL3,NPRL2,DEPDC5|
|negative regulation of TORC1 signaling|53.88|NPRL3,NPRL2,DEPDC5,TSC2|
|cellular response to amino acid starvation|46.02|NPRL3,NPRL2,DEPDC5,EIF2AK4|
|response to amino acid starvation|43.32|NPRL3,NPRL2,DEPDC5,EIF2AK4|
|negative regulation of TOR signaling|33.47|NPRL3,NPRL2,DEPDC5,TSC2|
|regulation of TORC1 signaling|25.69|NPRL3,NPRL2,DEPDC5,TSC2|
|cellular response to starvation|19.38|TP53,NPRL3,NPRL2,DEPDC5,EIF2AK4,TSC2|
|regulation of intrinsic apoptotic signaling pathway|15.96|TP53,DDX3X,RPL11,VDAC2,UBQLN1|
|response to starvation|15.78|TP53,NPRL3,NPRL2,DEPDC5,EIF2AK4,TSC2|
|response to endoplasmic reticulum stress|14.73|TP53,DDX3X,BAK1,EIF2AK4,UBQLN1,APAF1|
|cellular response to nutrient levels|14.22|TP53,NPRL3,NPRL2,DEPDC5,EIF2AK4,TSC2|
|cellular response to extracellular stimulus|12.65|TP53,NPRL3,NPRL2,DEPDC5,EIF2AK4,TSC2|
|cellular response to external stimulus|11.82|TP53,BAK1,NPRL3,NPRL2,DEPDC5,EIF2AK4,TSC2|
|regulation of apoptotic signaling pathway|10.34|TP53,DDX3X,BAK1,RPL11,VDAC2,UBQLN1,APAF1|
|enzyme activator activity|7.79|DDX3X,NPRL3,NPRL2,DEPDC5,PPP4R3A,APAF1,TSC2,PLAA|
|regulation of proteolysis|7.49|TP53,DDX3X,BAK1,RPL11,UBQLN1,APAF1,CDK2,RPL5|
|negative regulation of protein metabolic process|5.88|TP53,DDX3X,BAK1,RPL11,EIF2AK4,RPL5,TSC2,PLAA,PCIF1|
</modal>