====== Olaparib 4μM R08 exp512 ======
==== Mechanism of Action ====
Inhibits PARP1 and PARP2, blocks ssDNA break repair, selectively toxic to BRCA1/2 negative cancers
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / PARP Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Olaparib%%
    * **<color #00a2e8>Synonyms:</color>** AZD2281; KU0059436
    * **<color #00a2e8>CAS #:</color>** 763113-22-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/23725625|23725625]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
    * **<color #00a2e8>INCHI Key:</color>** FDLYAMZZIXQODN-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 434.5
    * **<color #00a2e8>Canonical SMILES:</color>** C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C24H23FN4O3
{{:chemogenomics:structures:chem-0317.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Med Chem Express
    * **<color #00a2e8>Catalog #:</color>** HY-10162
    * **<color #00a2e8>Lot #:</color>** 24830
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C24H23FN4O3 435.1827; found 435.18457
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Olaparib
    * **<color #00a2e8>Min:</color>** -6.7026; **<color #00a2e8>Max:</color>** 94.1282
{{:chemogenomics:dose_response:dr_566.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |2.5010    |
| IC20  |3.3100    |
| IC30  |3.9880    |
| IC40  |4.6460    |
| IC50  |5.3450    |
| IC60  |6.1490    |
| IC70  |7.1640    |
| IC80  |8.6310    |
| IC90  |11.4200    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 4µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.2
    * **<color #00a2e8>Numbers of reads</color>**: 17298761


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|42/114|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Olaparib_4uM_Round-8_exp512.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Olaparib 4μM R08 exp512'>
{{:chemogenomics:cranks_plots:exp512.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MCM9|MCM9]]|-4.83|0.00|
|[[:human_genes:P:PRDX1|PRDX1]]|-4.38|0.00|
|[[:human_genes:D:DNPH1|DNPH1]]|-3.97|0.00|
|[[:human_genes:S:SWSAP1|SWSAP1]]|-3.85|0.00|
|[[:human_genes:S:SMARCAL1|SMARCAL1]]|-3.83|0.00|
|[[:human_genes:A:APITD1|APITD1]]|-3.70|0.00|
|[[:human_genes:G:GTPBP2|GTPBP2]]|-3.65|0.00|
|[[:human_genes:P:POLB|POLB]]|-3.55|0.00|
|[[:human_genes:A:APITD1-CORT|APITD1-CORT]]|-3.48|0.00|
|[[:human_genes:U:UBE2N|UBE2N]]|-3.30|0.00|
|[[:human_genes:Z:ZBTB1|ZBTB1]]|-3.28|0.00|
|[[:human_genes:R:RAD54L|RAD54L]]|-3.24|0.00|
|[[:human_genes:H:HELLS|HELLS]]|-3.22|0.00|
|[[:human_genes:Z:ZSWIM7|ZSWIM7]]|-3.16|0.00|
|[[:human_genes:K:KPNA3|KPNA3]]|-3.13|<0.01|
|[[:human_genes:S:SIVA1|SIVA1]]|-3.03|<0.01|
|[[:human_genes:M:MDM2|MDM2]]|-3.03|<0.01|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.99|<0.01|
|[[:human_genes:H:HELQ|HELQ]]|-2.98|<0.01|
|[[:human_genes:V:VPS25|VPS25]]|-2.82|0.13|
|[[:human_genes:N:NFRKB|NFRKB]]|-2.73|<0.01|
|[[:human_genes:K:KPNA4|KPNA4]]|-2.68|<0.01|
|[[:human_genes:C:C1orf112|C1orf112]]|-2.67|<0.01|
|[[:human_genes:R:RNF168|RNF168]]|-2.67|<0.01|
|[[:human_genes:S:SPIDR|SPIDR]]|-2.67|<0.01|
|[[:human_genes:L:LIG3|LIG3]]|-2.66|0.01|
|[[:human_genes:I:ITPA|ITPA]]|-2.54|0.01|
|[[:human_genes:U:USP7|USP7]]|-2.54|0.02|
|[[:human_genes:S:STRA13|STRA13]]|-2.50|0.01|
|[[:human_genes:R:RNASEH2A|RNASEH2A]]|-2.49|0.05|
|[[:human_genes:C:CASP9|CASP9]]|3.35|0.00|
|[[:human_genes:C:CYCS|CYCS]]|3.36|0.00|
|[[:human_genes:P:PLAA|PLAA]]|3.41|0.00|
|[[:human_genes:A:ALAS1|ALAS1]]|3.42|<0.01|
|[[:human_genes:T:TFDP1|TFDP1]]|3.48|0.00|
|[[:human_genes:F:FAF2|FAF2]]|3.48|0.00|
|[[:human_genes:G:GCN1L1|GCN1L1]]|3.48|0.00|
|[[:human_genes:S:SLC20A1|SLC20A1]]|3.50|0.00|
|[[:human_genes:R:RPS25|RPS25]]|3.55|0.00|
|[[:human_genes:E:ENY2|ENY2]]|3.56|0.00|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.57|0.00|
|[[:human_genes:T:TRMT10A|TRMT10A]]|3.62|0.00|
|[[:human_genes:N:NSUN2|NSUN2]]|3.65|0.00|
|[[:human_genes:Z:ZCCHC8|ZCCHC8]]|3.71|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|3.82|0.00|
|[[:human_genes:D:DIABLO|DIABLO]]|3.88|0.00|
|[[:human_genes:R:RICTOR|RICTOR]]|3.98|0.00|
|[[:human_genes:M:MLST8|MLST8]]|4.02|0.00|
|[[:human_genes:P:PMAIP1|PMAIP1]]|4.26|0.00|
|[[:human_genes:I:IRF2|IRF2]]|4.28|0.00|
|[[:human_genes:P:PARP2|PARP2]]|4.53|0.00|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.53|0.00|
|[[:human_genes:A:AHCYL1|AHCYL1]]|4.60|0.00|
|[[:human_genes:A:APAF1|APAF1]]|4.97|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|5.41|0.00|
|[[:human_genes:A:ADPRHL2|ADPRHL2]]|5.99|0.00|
|[[:human_genes:B:BAK1|BAK1]]|6.55|0.00|
|[[:human_genes:S:SLFN11|SLFN11]]|6.79|0.00|
|[[:human_genes:T:TP53|TP53]]|7.12|0.00|
|[[:human_genes:P:PARP1|PARP1]]|7.76|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.204|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|0.088|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.086|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.083|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.082|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.079|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.077|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.075|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.074|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.072|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.069|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.067|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|0.064|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.063|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.059|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|0.058|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.057|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|0.055|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.055|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.16|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.121|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.117|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.116|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.115|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.113|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.105|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.104|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.093|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.092|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.091|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.09|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.09|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.086|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.081|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|0.078|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.076|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.076|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.076|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.075|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.073|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.073|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.072|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.07|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.07|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.069|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|0.066|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.066|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|0.065|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|0.064|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.062|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.061|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.06|<button type="primary" size="small" modal="52">View</button>|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|0.06|<button type="primary" size="small" modal="53">View</button>|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|0.057|<button type="primary" size="small" modal="54">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.057|<button type="primary" size="small" modal="55">View</button>|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|0.056|<button type="primary" size="small" modal="56">View</button>|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|0.056|<button type="primary" size="small" modal="57">View</button>|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|0.055|<button type="primary" size="small" modal="58">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.055|<button type="primary" size="small" modal="59">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.054|<button type="primary" size="small" modal="60">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.052|<button type="primary" size="small" modal="61">View</button>|
</modal>


<modal id="1" size="lg" title="Olaparib 4μM R08 exp512  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp512_vs_exp520.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Olaparib 4μM R08 exp512  vs  Talazoparib 0.006μM R06 exp299">
{{:chemogenomics:comparison_plots:exp299_vs_exp512.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Olaparib 4μM R08 exp512  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp512_vs_exp529.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Olaparib 4μM R08 exp512  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp512.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Olaparib 4μM R08 exp512  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp512_vs_exp535.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Olaparib 4μM R08 exp512  vs  Sulforaphane 9μM R08 exp525">
{{:chemogenomics:comparison_plots:exp512_vs_exp525.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Olaparib 4μM R08 exp512  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp512_vs_exp80.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Olaparib 4μM R08 exp512  vs  Pterostilbene 16μM R02 exp78">
{{:chemogenomics:comparison_plots:exp512_vs_exp78.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Olaparib 4μM R08 exp512  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp512_vs_exp531.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Olaparib 4μM R08 exp512  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp512_vs_exp524.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Olaparib 4μM R08 exp512  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp28_vs_exp512.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Olaparib 4μM R08 exp512  vs  Quercetin 20μM R08 exp517">
{{:chemogenomics:comparison_plots:exp512_vs_exp517.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Olaparib 4μM R08 exp512  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp512_vs_exp526.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Olaparib 4μM R08 exp512  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp512_vs_exp85.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Olaparib 4μM R08 exp512  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp512_vs_exp515.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Olaparib 4μM R08 exp512  vs  TRAIL 50ng/ml R00 exp36">
{{:chemogenomics:comparison_plots:exp36_vs_exp512.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Olaparib 4μM R08 exp512  vs  Pyridostatin 4μM R05 exp240">
{{:chemogenomics:comparison_plots:exp240_vs_exp512.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Olaparib 4μM R08 exp512  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp512.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Olaparib 4μM R08 exp512  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp512.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp440_vs_exp512.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp503_vs_exp512.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp489_vs_exp512.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp354_vs_exp512.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp488_vs_exp512.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Benzoate 20000μM R08 exp456  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp456_vs_exp512.png?nolink |}}
</modal>

<modal id="26" size="lg" title="MS023 7μM R03 exp135  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp135_vs_exp512.png?nolink |}}
</modal>

<modal id="27" size="lg" title="AICAR 240μM R05 exp211  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp211_vs_exp512.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Ethanol 0.01 R05 exp234  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp234_vs_exp512.png?nolink |}}
</modal>

<modal id="29" size="lg" title="GSK626616 14μM R08 exp485  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp485_vs_exp512.png?nolink |}}
</modal>

<modal id="30" size="lg" title="AICAR 240μM R03 exp116  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp116_vs_exp512.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Bleomycin 5μM R08 exp459  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="32" size="lg" title="MS023 2μM R03 exp134  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="33" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="34" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="35" size="lg" title="Nutlin-3A 1.6μM R06 exp294  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="36" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="37" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="38" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="39" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="40" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="41" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp329_vs_exp512.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Latrunculin-B 10μM R07 exp374  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="43" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="44" size="lg" title="JQ1 0.8μM R08 exp435  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp435_vs_exp512.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="46" size="lg" title="Cytochalasin-B 5μM R07 exp349  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="47" size="lg" title="Artemisinin 50μM R08 exp450  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp450_vs_exp512.png?nolink |}}
</modal>

<modal id="48" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="49" size="lg" title="Etoposide 0.1μM R05 exp198  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp198_vs_exp512.png?nolink |}}
</modal>

<modal id="50" size="lg" title="MLN-4924 0.2μM R00 exp21  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="51" size="lg" title="ML-792 0.2μM R08 exp505  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp505_vs_exp512.png?nolink |}}
</modal>

<modal id="52" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp468_vs_exp512.png?nolink |}}
</modal>

<modal id="53" size="lg" title="Bortezomib 0.005μM R00 exp6  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp512_vs_exp6.png?nolink |}}
</modal>

<modal id="54" size="lg" title="Aminopterin 0.005μM R07 exp335  vs  Olaparib 4μM R08 exp512">
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</modal>

<modal id="55" size="lg" title="Etoposide 1μM R00 exp19  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp19_vs_exp512.png?nolink |}}
</modal>

<modal id="56" size="lg" title="Campthothecin 0.001μM R06 exp270  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp270_vs_exp512.png?nolink |}}
</modal>

<modal id="57" size="lg" title="3-Bromopyruvate 7μM R04 exp175  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp175_vs_exp512.png?nolink |}}
</modal>

<modal id="58" size="lg" title="MK-1775 0.32μM R02 exp75  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp512_vs_exp75.png?nolink |}}
</modal>

<modal id="59" size="lg" title="Lead acetate 2000μM R08 exp497  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp497_vs_exp512.png?nolink |}}
</modal>

<modal id="60" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp498_vs_exp512.png?nolink |}}
</modal>

<modal id="61" size="lg" title="GSK-J4 1.5μM R08 exp441  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp441_vs_exp512.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|interstrand cross-link repair|72.20|MCM9,CENPS,RNF168,CENPX|
|double-strand break repair via nonhomologous end joining|58.44|SMARCAL1,POLB,HELQ,RNF168|
|DNA-templated DNA replication maintenance of fidelity|46.31|MCM9,SMARCAL1,CENPS,CENPX|
|recombinational repair|41.25|MCM9,SWSAP1,UBE2N,RAD54L,ZSWIM7,HELQ,SPIDR,LIG3|
|double-strand break repair via homologous recombination|37.03|MCM9,UBE2N,RAD54L,ZSWIM7,HELQ,SPIDR,LIG3|
|DNA recombination|35.77|MCM9,SWSAP1,CENPS,POLB,UBE2N,RAD54L,ZSWIM7,HELQ,NFRKB,RNF168,SPIDR,LIG3,CENPX|
|double-strand break repair|33.58|MCM9,SWSAP1,SMARCAL1,POLB,UBE2N,RAD54L,ZSWIM7,HELQ,RNF168,SPIDR,LIG3|
|DNA-templated DNA replication|28.32|MCM9,SMARCAL1,CENPS,POLB,LIG3,CENPX|
|ATP-dependent activity, acting on DNA|26.92|MCM9,SMARCAL1,RAD54L,HELLS,HELQ|
|positive regulation of DNA repair|25.36|UBE2N,HELQ,NFRKB,RNF168,SPIDR|
|response to ionizing radiation|23.24|POLB,RAD54L,MDM2,RNF168,SPIDR|
|DNA repair|20.94|MCM9,SWSAP1,SMARCAL1,CENPS,POLB,UBE2N,ZBTB1,RAD54L,ZSWIM7,HELQ,NFRKB,RNF168,SPIDR,LIG3,USP7,CENPX|
|helicase activity|20.59|MCM9,SMARCAL1,RAD54L,HELLS,HELQ|
|DNA replication|19.08|MCM9,SMARCAL1,CENPS,POLB,LIG3,CENPX|
|catalytic activity, acting on DNA|18.28|MCM9,SMARCAL1,POLB,RAD54L,HELLS,HELQ,LIG3|
|DNA damage response|14.65|MCM9,SWSAP1,SMARCAL1,CENPS,POLB,UBE2N,ZBTB1,RAD54L,ZSWIM7,MDM2,HELQ,NFRKB,RNF168,SPIDR,LIG3,USP7,CENPX|
|DNA metabolic process|14.61|MCM9,SWSAP1,SMARCAL1,CENPS,POLB,UBE2N,ZBTB1,RAD54L,HELLS,ZSWIM7,HELQ,NFRKB,RNF168,SPIDR,LIG3,USP7,CENPX|
|positive regulation of DNA metabolic process|12.92|UBE2N,HELQ,NFRKB,RNF168,SPIDR,USP7|
|chromosome organization|9.76|MCM9,SMARCAL1,RAD54L,HELQ,NFRKB,ITPA,CENPX|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.30|APAF1,CASP9|
|NAD DNA ADP-ribosyltransferase activity|552.30|PARP1,PARP2|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|441.84|APAF1,DIABLO,CYCS,CASP9|
|TORC2 complex|207.11|MAPKAP1,MLST8,RICTOR|
|regulation of mitochondrial membrane permeability|40.17|TP53,BAK1,PMAIP1,VDAC2|
|apoptotic mitochondrial changes|39.45|TP53,BAK1,PMAIP1,VDAC2|
|neuron apoptotic process|27.34|TP53,APAF1,PARP2,DIABLO,CASP9|
|positive regulation of cysteine-type endopeptidase activity|26.94|BAK1,APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|26.30|APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|site of DNA damage|25.57|PARP1,TP53,SLFN11,ADPRS,PARP2|
|intrinsic apoptotic signaling pathway|24.16|TP53,BAK1,APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|positive regulation of endopeptidase activity|23.01|BAK1,APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|positive regulation of peptidase activity|20.97|BAK1,APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|regulation of cysteine-type endopeptidase activity|17.72|BAK1,APAF1,PMAIP1,DIABLO,CYCS,CASP9|
|apoptotic signaling pathway|16.14|TP53,BAK1,APAF1,PARP2,PMAIP1,DIABLO,VDAC2,CYCS,CASP9|
|cellular response to external stimulus|11.82|TP53,BAK1,MAPKAP1,PMAIP1,MLST8,RICTOR,GCN1|
|response to nutrient levels|9.34|TP53,APAF1,MAPKAP1,PARP2,PMAIP1,MLST8,RICTOR,GCN1|
|response to extracellular stimulus|8.80|TP53,APAF1,MAPKAP1,PARP2,PMAIP1,MLST8,RICTOR,GCN1|
|DNA damage response|6.98|PARP1,TP53,SLFN11,BAK1,ADPRS,PARP2,PMAIP1,MLST8,CASP9|
</modal>