====== Sulforaphane 9μM R08 exp526 no dilution day6 ======
==== Mechanism of Action ====
Organosulfur compound, found in cruciferous plants
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Natural Product




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Sulforaphane%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 4478-93-7
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/5350|5350]]
    * **<color #00a2e8>IUPAC:</color>** %%1-isothiocyanato-4-methylsulfinylbutane%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3
    * **<color #00a2e8>INCHI Key:</color>** SUVMJBTUFCVSAD-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 177.3
    * **<color #00a2e8>Canonical SMILES:</color>** CS(=O)CCCCN=C=S
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C6H11NOS2
{{:chemogenomics:structures:chem-0330.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** S699115
    * **<color #00a2e8>Lot #:</color>** 5-YMK-45-1
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C6H11NOS2 200.01743; found 200.01687
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Sulforaphane
    * **<color #00a2e8>Min:</color>** -21.7878; **<color #00a2e8>Max:</color>** 99.8167
{{:chemogenomics:dose_response:dr_582.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |8.1350    |
| IC20  |8.8770    |
| IC30  |9.4080    |
| IC40  |9.8670    |
| IC50  |10.3100    |
| IC60  |10.7700    |
| IC70  |11.2900    |
| IC80  |11.9700    |
| IC90  |13.0600    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 08
    * **<color #00a2e8>Dose</color>**: 9µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.5
    * **<color #00a2e8>Numbers of reads</color>**: 14952951


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|7/15|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Sulforaphane_9uM_Round-8_exp526.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Sulforaphane 9μM R08 exp526 no dilution day6'>
{{:chemogenomics:cranks_plots:exp526.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:T:TCF4|TCF4]]|-3.72|<0.01|
|[[:human_genes:D:DLGAP5|DLGAP5]]|-3.16|<0.01|
|[[:human_genes:P:PAG1|PAG1]]|-2.89|0.02|
|[[:human_genes:N:NPRL2|NPRL2]]|-2.81|0.05|
|[[:human_genes:V:VBP1|VBP1]]|-2.79|0.02|
|[[:human_genes:G:GAK|GAK]]|-2.74|0.02|
|[[:human_genes:K:KIF22|KIF22]]|-2.64|0.03|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.57|0.06|
|[[:human_genes:M:MSI2|MSI2]]|-2.55|0.04|
|[[:human_genes:U:UBE2C|UBE2C]]|-2.45|0.05|
|[[:human_genes:P:PPME1|PPME1]]|-2.40|0.09|
|[[:human_genes:P:PSMA7|PSMA7]]|-2.40|0.22|
|[[:human_genes:S:SEPHS1|SEPHS1]]|-2.39|0.07|
|[[:human_genes:I:IPO11|IPO11]]|-2.34|0.08|
|[[:human_genes:K:KPNB1|KPNB1]]|-2.30|0.36|
|[[:human_genes:H:HNRNPM|HNRNPM]]|-2.29|0.09|
|[[:human_genes:M:MON2|MON2]]|-2.29|0.09|
|[[:human_genes:C:CSK|CSK]]|-2.29|0.09|
|[[:human_genes:P:PPIL2|PPIL2]]|-2.27|0.14|
|[[:human_genes:K:KIF4A|KIF4A]]|-2.26|0.09|
|[[:human_genes:K:KEAP1|KEAP1]]|-2.25|0.14|
|[[:human_genes:R:RANBP1|RANBP1]]|-2.22|0.11|
|[[:human_genes:M:MTMR4|MTMR4]]|-2.17|0.14|
|[[:human_genes:T:TNPO1|TNPO1]]|-2.17|0.20|
|[[:human_genes:M:MKLN1|MKLN1]]|-2.16|0.14|
|[[:human_genes:M:MAPK11|MAPK11]]|-2.15|0.20|
|[[:human_genes:Q:QSER1|QSER1]]|-2.14|0.14|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.14|0.14|
|[[:human_genes:T:TACC3|TACC3]]|-2.13|0.14|
|[[:human_genes:W:WDR61|WDR61]]|-2.12|0.21|
|[[:human_genes:L:LOC391322|LOC391322]]|2.10|0.68|
|[[:human_genes:N:NSD1|NSD1]]|2.14|0.20|
|[[:human_genes:L:LRP6|LRP6]]|2.14|0.15|
|[[:human_genes:E:EIF4G1|EIF4G1]]|2.15|0.20|
|[[:human_genes:S:SYT14|SYT14]]|2.17|0.20|
|[[:human_genes:C:CD79A|CD79A]]|2.18|0.20|
|[[:human_genes:P:PDPK1|PDPK1]]|2.19|0.12|
|[[:human_genes:G:GANAB|GANAB]]|2.19|0.23|
|[[:human_genes:R:ROMO1|ROMO1]]|2.19|0.23|
|[[:human_genes:A:ADCY1|ADCY1]]|2.21|0.20|
|[[:human_genes:A:ADIPOR1|ADIPOR1]]|2.33|0.06|
|[[:human_genes:P:PQBP1|PQBP1]]|2.34|0.06|
|[[:human_genes:L:LSM14A|LSM14A]]|2.37|0.10|
|[[:human_genes:C:CD19|CD19]]|2.44|0.07|
|[[:human_genes:P:PRADC1|PRADC1]]|2.47|0.03|
|[[:human_genes:D:DPH6|DPH6]]|2.56|0.02|
|[[:human_genes:P:PPIP5K2|PPIP5K2]]|2.58|0.04|
|[[:human_genes:S:SMC1A|SMC1A]]|2.70|0.20|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.78|0.02|
|[[:human_genes:S:SLC4A7|SLC4A7]]|2.78|0.02|
|[[:human_genes:P:PIK3CD|PIK3CD]]|2.78|<0.01|
|[[:human_genes:C:CD81|CD81]]|2.86|<0.01|
|[[:human_genes:S:SYK|SYK]]|3.01|<0.01|
|[[:human_genes:R:RICTOR|RICTOR]]|3.23|<0.01|
|[[:human_genes:R:RHOH|RHOH]]|3.41|<0.01|
|[[:human_genes:M:MLST8|MLST8]]|3.50|<0.01|
|[[:human_genes:S:SRM|SRM]]|3.62|<0.01|
|[[:human_genes:A:AHCYL1|AHCYL1]]|3.68|<0.01|
|[[:human_genes:M:MAPKAP1|MAPKAP1]]|4.15|<0.01|
|[[:human_genes:A:AKT2|AKT2]]|4.30|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.079|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|0.062|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|0.061|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|0.06|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|0.297|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.092|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.088|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.085|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.083|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.081|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.079|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.074|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp274|Citral 50μM R06 exp274]]|0.066|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|0.065|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.065|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.064|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|0.064|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|0.064|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|0.062|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.061|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|0.061|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|0.06|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.06|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.059|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.059|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|0.058|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|0.058|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.057|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.056|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.053|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|0.052|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp275|Citral 75μM R06 exp275]]|0.052|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.051|<button type="primary" size="small" modal="33">View</button>|
</modal>


<modal id="1" size="lg" title="Sulforaphane 9μM R08 exp526 no dilution day6  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp526_vs_exp535.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Sulforaphane 9μM R08 exp526 no dilution day6  vs  Taxol 0.004μM R03 exp103">
{{:chemogenomics:comparison_plots:exp103_vs_exp526.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Sulforaphane 9μM R08 exp526 no dilution day6  vs  Vincristine 0.0005μM R04 exp190">
{{:chemogenomics:comparison_plots:exp190_vs_exp526.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Sulforaphane 9μM R08 exp526 no dilution day6  vs  Thimerosal 0.85μM R08 exp529">
{{:chemogenomics:comparison_plots:exp526_vs_exp529.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Sulforaphane 9μM R08 exp525  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp525_vs_exp526.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp488_vs_exp526.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Rucaparib 6.5μM R08 exp520  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp520_vs_exp526.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp489_vs_exp526.png?nolink |}}
</modal>

<modal id="9" size="lg" title="MLN-4924 0.2μM R00 exp21  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp21_vs_exp526.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp440_vs_exp526.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Benzoate 20000μM R08 exp456  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp456_vs_exp526.png?nolink |}}
</modal>

<modal id="12" size="lg" title="AICAR 240μM R03 exp116  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp116_vs_exp526.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Citral 50μM R06 exp274  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp274_vs_exp526.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Lead acetate 2000μM R08 exp498 no dilution day6  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp498_vs_exp526.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Quercetin 20μM R08 exp517  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp517_vs_exp526.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Olaparib 4μM R08 exp512  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp512_vs_exp526.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp102_vs_exp526.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Combretastatin A4 0.002 to 0.003μM day4 R04 exp179  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp179_vs_exp526.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Lead acetate 2000μM R08 exp497  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp497_vs_exp526.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BML-284 0.09μM R08 exp460  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp460_vs_exp526.png?nolink |}}
</modal>

<modal id="21" size="lg" title="All-trans-Retinoic-Acid 40μM R07 exp334  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp334_vs_exp526.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Demecolcine 0.03μM R05 exp228  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp228_vs_exp526.png?nolink |}}
</modal>

<modal id="23" size="lg" title="MS023 2μM R03 exp134  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp134_vs_exp526.png?nolink |}}
</modal>

<modal id="24" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp468_vs_exp526.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Ethanol 0.01 R05 exp234  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp234_vs_exp526.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Ixabepilone 0.004 to 0.005μM on day4 R04 exp184  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp184_vs_exp526.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Arsenate 40μM R06 exp264  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp264_vs_exp526.png?nolink |}}
</modal>

<modal id="28" size="lg" title="B02 10μM R08 exp453  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp453_vs_exp526.png?nolink |}}
</modal>

<modal id="29" size="lg" title="ML-792 0.2μM R08 exp505  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp505_vs_exp526.png?nolink |}}
</modal>

<modal id="30" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp500_vs_exp526.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Benzoate 10000μM R08 exp455  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp455_vs_exp526.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Citral 75μM R06 exp275  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp275_vs_exp526.png?nolink |}}
</modal>

<modal id="33" size="lg" title="LY2090314 0.003μM R08 exp499  vs  Sulforaphane 9μM R08 exp526 no dilution day6">
{{:chemogenomics:comparison_plots:exp499_vs_exp526.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|mitotic chromosome movement towards spindle pole|394.50|DLGAP5,KPNB1|
|ribosomal protein import into nucleus|394.50|IPO11,KPNB1|
|mitotic spindle organization|24.92|DLGAP5,KPNB1,KIF4A,TACC3|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|TORC2 complex|207.11|MAPKAP1,MLST8,RICTOR|
|B cell receptor signaling pathway|51.38|SYK,PIK3CD,CD19,CD79A|
</modal>