====== Mubritinib 0.2μM R02 exp65 ======
==== Mechanism of Action ====
Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase
  * **<color #00a2e8>Class / Subclass 1:</color>** Signal Transduction / Kinase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Mubritinib%%
    * **<color #00a2e8>Synonyms:</color>** TAK-165
    * **<color #00a2e8>CAS #:</color>** 366017-09-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/6444692|6444692]]
    * **<color #00a2e8>IUPAC:</color>** %%4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
    * **<color #00a2e8>INCHI Key:</color>** ZTFBIUXIQYRUNT-MDWZMJQESA-N
    * **<color #00a2e8>Molecular Weight:</color>** 468.5
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F
    * **<color #00a2e8>Molecular Formula:</color>** C25H23F3N4O2
{{:chemogenomics:structures:chem-0028.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Selleck Chemicals
    * **<color #00a2e8>Catalog #:</color>** S2216
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 1.31 min, m/z 469+ [M+H]+
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** MUTRITINIB
    * **<color #00a2e8>Min:</color>** -5.4651; **<color #00a2e8>Max:</color>** 38.1718
{{:chemogenomics:dose_response:dr_96.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 200nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 3.5
    * **<color #00a2e8>Numbers of reads</color>**: 11836345


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|3/11|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Mubritinib_0.2uM_Round-2_exp65.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Mubritinib 0.2μM R02 exp65'>
{{:chemogenomics:cranks_plots:exp65.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:H:HK1|HK1]]|-3.36|<0.01|
|[[:human_genes:G:GOT1|GOT1]]|-3.34|<0.01|
|[[:human_genes:P:PDXK|PDXK]]|-3.01|<0.01|
|[[:human_genes:C:CDC20|CDC20]]|-2.99|0.30|
|[[:human_genes:C:CDIPT|CDIPT]]|-2.87|0.30|
|[[:human_genes:A:AHCYL1|AHCYL1]]|-2.77|0.06|
|[[:human_genes:B:BSG|BSG]]|-2.66|0.07|
|[[:human_genes:T:TBCD|TBCD]]|-2.43|0.30|
|[[:human_genes:S:SARS|SARS]]|-2.40|0.63|
|[[:human_genes:O:OR5P3|OR5P3]]|-2.27|0.33|
|[[:human_genes:C:CPSF7|CPSF7]]|-2.25|0.30|
|[[:human_genes:R:RBM14|RBM14]]|-2.25|0.30|
|[[:human_genes:B:BCAT1|BCAT1]]|-2.24|0.30|
|[[:human_genes:R:RBM14-RBM4|RBM14-RBM4]]|-2.22|0.30|
|[[:human_genes:U:UBE2QL1|UBE2QL1]]|-2.19|0.30|
|[[:human_genes:A:ACACA|ACACA]]|-2.19|0.30|
|[[:human_genes:W:WSB1|WSB1]]|-2.11|0.58|
|[[:human_genes:S:SCN3A|SCN3A]]|-2.10|0.34|
|[[:human_genes:P:PGP|PGP]]|-2.10|0.30|
|[[:human_genes:C:C17orf64|C17orf64]]|-2.07|0.30|
|[[:human_genes:P:PNP|PNP]]|-2.07|0.30|
|[[:human_genes:Z:ZNF169|ZNF169]]|-2.05|0.30|
|[[:human_genes:G:GPD2|GPD2]]|-2.04|0.30|
|[[:human_genes:T:TACR3|TACR3]]|-2.01|0.33|
|[[:human_genes:A:ADAM28|ADAM28]]|-2.00|0.33|
|[[:human_genes:A:ARHGAP1|ARHGAP1]]|-2.00|0.42|
|[[:human_genes:R:RBMX|RBMX]]|-1.98|0.52|
|[[:human_genes:L:LOC147646|LOC147646]]|-1.97|0.43|
|[[:human_genes:C:C15orf27|C15orf27]]|-1.95|0.39|
|[[:human_genes:G:GLIS2|GLIS2]]|-1.95|0.45|
|[[:human_genes:T:TMEM165|TMEM165]]|2.30|0.08|
|[[:human_genes:P:PARS2|PARS2]]|2.31|0.11|
|[[:human_genes:M:MRPS27|MRPS27]]|2.34|0.15|
|[[:human_genes:C:CLUH|CLUH]]|2.35|0.07|
|[[:human_genes:A:ATP5F1|ATP5F1]]|2.35|0.07|
|[[:human_genes:R:RNASEH1|RNASEH1]]|2.36|0.06|
|[[:human_genes:D:DPH3|DPH3]]|2.36|0.07|
|[[:human_genes:Z:ZNF812|ZNF812]]|2.36|0.07|
|[[:human_genes:L:LARS2|LARS2]]|2.36|0.07|
|[[:human_genes:E:ENY2|ENY2]]|2.42|0.09|
|[[:human_genes:R:RBM33|RBM33]]|2.45|0.08|
|[[:human_genes:D:DARS2|DARS2]]|2.46|0.08|
|[[:human_genes:L:LUC7L3|LUC7L3]]|2.48|0.17|
|[[:human_genes:D:DIAPH3|DIAPH3]]|2.51|0.07|
|[[:human_genes:N:NR2C2AP|NR2C2AP]]|2.51|0.07|
|[[:human_genes:P:PREPL|PREPL]]|2.52|0.06|
|[[:human_genes:F:FASTKD1|FASTKD1]]|2.53|0.06|
|[[:human_genes:P:PRKAG1|PRKAG1]]|2.57|0.02|
|[[:human_genes:A:AKAP12|AKAP12]]|2.57|0.07|
|[[:human_genes:T:TOP1MT|TOP1MT]]|2.68|0.08|
|[[:human_genes:P:POLG|POLG]]|2.93|<0.01|
|[[:human_genes:I:IPPK|IPPK]]|3.18|<0.01|
|[[:human_genes:P:PGM3|PGM3]]|3.19|<0.01|
|[[:human_genes:C:CXorf56|CXorf56]]|3.21|<0.01|
|[[:human_genes:P:POLRMT|POLRMT]]|3.23|<0.01|
|[[:human_genes:P:PTMA|PTMA]]|3.30|0.01|
|[[:human_genes:I:IPMK|IPMK]]|3.41|<0.01|
|[[:human_genes:S:SLC7A1|SLC7A1]]|3.41|<0.01|
|[[:human_genes:A:ACSL3|ACSL3]]|3.64|<0.01|
|[[:human_genes:S:SLC25A51|SLC25A51]]|5.04|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|0.114|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|0.093|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|0.083|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|0.079|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|0.068|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|0.064|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|0.059|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|0.119|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|0.094|<button type="primary" size="small" modal="9">View</button>|
</modal>


<modal id="1" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  Rotenone 0.07μM R08 exp431">
{{:chemogenomics:comparison_plots:exp431_vs_exp65.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  QNZ 0.01μM R05 exp241">
{{:chemogenomics:comparison_plots:exp241_vs_exp65.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  QNZ 0.01μM R08 exp439">
{{:chemogenomics:comparison_plots:exp439_vs_exp65.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  Phenformin 20μM R05 exp212">
{{:chemogenomics:comparison_plots:exp212_vs_exp65.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  Oligomycin-A 2μM R00 exp25">
{{:chemogenomics:comparison_plots:exp25_vs_exp65.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  iCRT14 30μM R08 exp492">
{{:chemogenomics:comparison_plots:exp492_vs_exp65.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Mubritinib 0.2μM R02 exp65  vs  NMS-873 0.07μM R07 exp380">
{{:chemogenomics:comparison_plots:exp380_vs_exp65.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Mubritinib 0.2μM R01 exp48  vs  Mubritinib 0.2μM R02 exp65">
{{:chemogenomics:comparison_plots:exp48_vs_exp65.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Chloramphenicol 20μM R00 exp13  vs  Mubritinib 0.2μM R02 exp65">
{{:chemogenomics:comparison_plots:exp13_vs_exp65.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|glycerol metabolic process|104.74|GOT1,PGP,GPD2|
|alditol metabolic process|94.77|GOT1,PGP,GPD2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|NAD transmembrane transport|276.40|SLC25A51,SLC25A52|
|NAD transmembrane transporter activity|276.40|SLC25A51,SLC25A52|
|mitochondrial gene expression|19.88|POLRMT,FASTKD1,DARS2,LARS2,MRPS27|
|mitochondrial matrix|11.64|POLRMT,POLG,TOP1MT,FASTKD1,DARS2,LARS2,ATP5PB,MRPS27,PARS2,NDUFA10|
</modal>