====== Q15 2.7μM R02 exp79 ======
==== Mechanism of Action ====
Putative condensin inhibitor
  * **<color #00a2e8>Class / Subclass 1:</color>** Cell Cycle / Chromosome Dynamics Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 1071780-64-7
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 584.0421
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C31H27ClFN7O2
{{:chemogenomics:structures:chem-0055.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Chemistry Platform
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C31H27ClFN7O2 584.19716; found 584.19427
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Q15
    * **<color #00a2e8>Min:</color>** -15.2028; **<color #00a2e8>Max:</color>** 99.7587
{{:chemogenomics:dose_response:dr_22.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |2.4826    |
| IC30  |2.6903    |
| IC40  |2.8735    |
| IC50  |3.0525    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 2.7µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.6
    * **<color #00a2e8>Numbers of reads</color>**: 11718749


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|23/34|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Q15_2.7uM_Round-2_exp79.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Q15 2.7μM R02 exp79'>
{{:chemogenomics:cranks_plots:exp79.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:V:VKORC1L1|VKORC1L1]]|-4.08|<0.01|
|[[:human_genes:A:ACBD3|ACBD3]]|-3.95|<0.01|
|[[:human_genes:D:DDX23|DDX23]]|-3.63|0.03|
|[[:human_genes:O:OSBPL11|OSBPL11]]|-3.62|<0.01|
|[[:human_genes:L:LDLR|LDLR]]|-3.53|<0.01|
|[[:human_genes:S:SPTLC2|SPTLC2]]|-3.52|<0.01|
|[[:human_genes:C:CHKA|CHKA]]|-3.40|<0.01|
|[[:human_genes:O:OSBPL8|OSBPL8]]|-3.33|<0.01|
|[[:human_genes:A:ATP6V0A2|ATP6V0A2]]|-3.31|<0.01|
|[[:human_genes:O:OSBPL9|OSBPL9]]|-3.24|<0.01|
|[[:human_genes:U:UPF2|UPF2]]|-3.04|0.23|
|[[:human_genes:H:HSPE1|HSPE1]]|-3.03|0.06|
|[[:human_genes:C:COMMD5|COMMD5]]|-2.76|<0.01|
|[[:human_genes:A:AP5S1|AP5S1]]|-2.69|0.01|
|[[:human_genes:C:COL4A3BP|COL4A3BP]]|-2.62|0.01|
|[[:human_genes:A:ATP6V1B2|ATP6V1B2]]|-2.56|0.04|
|[[:human_genes:R:RPS14|RPS14]]|-2.54|0.10|
|[[:human_genes:F:FLVCR1|FLVCR1]]|-2.51|0.04|
|[[:human_genes:P:PCYT1A|PCYT1A]]|-2.51|0.03|
|[[:human_genes:R:RAB1B|RAB1B]]|-2.51|0.03|
|[[:human_genes:S:SCAP|SCAP]]|-2.47|0.04|
|[[:human_genes:D:DAGLB|DAGLB]]|-2.46|0.03|
|[[:human_genes:P:PSMA5|PSMA5]]|-2.45|0.22|
|[[:human_genes:C:CLVS1|CLVS1]]|-2.45|0.03|
|[[:human_genes:R:RPL18A|RPL18A]]|-2.45|0.03|
|[[:human_genes:W:WDR7|WDR7]]|-2.43|0.06|
|[[:human_genes:C:COPB1|COPB1]]|-2.42|0.23|
|[[:human_genes:S:SCYL3|SCYL3]]|-2.41|0.06|
|[[:human_genes:U:UNC50|UNC50]]|-2.40|0.04|
|[[:human_genes:T:TRAPPC13|TRAPPC13]]|-2.39|0.04|
|[[:human_genes:R:RFK|RFK]]|2.43|0.02|
|[[:human_genes:P:PGLS|PGLS]]|2.46|0.02|
|[[:human_genes:Z:ZNF562|ZNF562]]|2.48|0.02|
|[[:human_genes:A:ATP5L|ATP5L]]|2.50|0.03|
|[[:human_genes:C:C12orf44|C12orf44]]|2.59|0.01|
|[[:human_genes:W:WSB1|WSB1]]|2.59|0.14|
|[[:human_genes:L:LCLAT1|LCLAT1]]|2.60|0.01|
|[[:human_genes:D:DNAJC3|DNAJC3]]|2.62|<0.01|
|[[:human_genes:S:SLC20A1|SLC20A1]]|2.69|0.01|
|[[:human_genes:Z:ZCRB1|ZCRB1]]|2.70|0.01|
|[[:human_genes:P:PI4K2B|PI4K2B]]|2.79|<0.01|
|[[:human_genes:W:WIBG|WIBG]]|2.97|0.02|
|[[:human_genes:I:INSIG1|INSIG1]]|2.98|<0.01|
|[[:human_genes:C:CDS2|CDS2]]|3.00|0.02|
|[[:human_genes:E:ELF1|ELF1]]|3.03|<0.01|
|[[:human_genes:S:SP1|SP1]]|3.05|<0.01|
|[[:human_genes:R:RPE|RPE]]|3.16|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|3.21|<0.01|
|[[:human_genes:N:NONO|NONO]]|3.28|0.00|
|[[:human_genes:P:PFKP|PFKP]]|3.39|0.00|
|[[:human_genes:S:SLC5A3|SLC5A3]]|3.52|0.00|
|[[:human_genes:T:TKT|TKT]]|3.56|0.00|
|[[:human_genes:U:UBE2G1|UBE2G1]]|3.61|0.00|
|[[:human_genes:G:GPI|GPI]]|3.63|<0.01|
|[[:human_genes:A:ACACA|ACACA]]|4.27|0.00|
|[[:human_genes:H:HK2|HK2]]|4.31|0.00|
|[[:human_genes:C:CHP1|CHP1]]|5.29|0.00|
|[[:human_genes:P:PGP|PGP]]|5.60|0.00|
|[[:human_genes:A:AGPAT6|AGPAT6]]|6.13|0.00|
|[[:human_genes:K:KCTD5|KCTD5]]|6.16|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|0.101|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|0.089|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|0.069|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|0.054|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.164|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|0.102|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.073|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|0.072|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|0.059|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|0.053|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.051|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.051|<button type="primary" size="small" modal="12">View</button>|
</modal>


<modal id="1" size="lg" title="Q15 2.7μM R02 exp79  vs  Vemurafenib 6.6μM R02 exp89">
{{:chemogenomics:comparison_plots:exp79_vs_exp89.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Q15 2.7μM R02 exp79  vs  Vemurafenib 6.6μM R08 exp434">
{{:chemogenomics:comparison_plots:exp434_vs_exp79.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Q15 2.7μM R02 exp79  vs  UM0125461 0.74μM R02 exp84">
{{:chemogenomics:comparison_plots:exp79_vs_exp84.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Q15 2.7μM R02 exp79  vs  WYE-354 6μM R02 exp90">
{{:chemogenomics:comparison_plots:exp79_vs_exp90.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Q15 1 to 2μM on day4 R04 exp164  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp164_vs_exp79.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Clomiphene 4.4μM R02 exp68  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp68_vs_exp79.png?nolink |}}
</modal>

<modal id="7" size="lg" title="BH1 1μM R04 exp169  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp169_vs_exp79.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Bafilomycin-A1 0.009μM R08 exp454  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp454_vs_exp79.png?nolink |}}
</modal>

<modal id="9" size="lg" title="CFI-400945 25μM R08 exp469  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp469_vs_exp79.png?nolink |}}
</modal>

<modal id="10" size="lg" title="∆-9-Tetrahydrocannabinol 30μM R08 exp445  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp445_vs_exp79.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Bortezomib 0.05μM R00 exp7  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp7_vs_exp79.png?nolink |}}
</modal>

<modal id="12" size="lg" title="FTY720 3μM R08 exp483  vs  Q15 2.7μM R02 exp79">
{{:chemogenomics:comparison_plots:exp483_vs_exp79.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|pentose-phosphate shunt, non-oxidative branch|221.12|TKT,RPE|
|CDP-diacylglycerol biosynthetic process|138.20|GPAT4,CDS2,LCLAT1|
|CDP-diacylglycerol metabolic process|138.20|GPAT4,CDS2,LCLAT1|
|pentose-phosphate shunt|138.20|TKT,RPE,PGLS|
|glucose 6-phosphate metabolic process|138.20|HK2,GPI,TKT,RPE,PGLS|
|NADPH regeneration|110.56|TKT,RPE,PGLS|
|generation of precursor metabolites and energy|11.76|HK2,GPI,TKT,PFKP,RPE,ATP5MG,PGLS,NDUFB11|
|glycerolipid metabolic process|9.76|GPAT4,PGP,CDS2,INSIG1,PI4K2B,LCLAT1|
|purine nucleotide metabolic process|9.70|GPAT4,ACACA,TKT,RPE,ATP5MG,PGLS,NDUFB11|
|nucleotide metabolic process|9.66|GPAT4,ACACA,TKT,RPE,ATP5MG,PGLS,RFK,NDUFB11|
|organophosphate metabolic process|9.60|GPAT4,PGP,HK2,ACACA,GPI,TKT,PFKP,RPE,CDS2,PI4K2B,LCLAT1,ATP5MG,PGLS,RFK,NDUFB11|
|organophosphate biosynthetic process|9.59|GPAT4,ACACA,TKT,CDS2,PI4K2B,LCLAT1,ATP5MG,RFK,NDUFB11|
|nucleoside phosphate metabolic process|9.47|GPAT4,ACACA,TKT,RPE,ATP5MG,PGLS,RFK,NDUFB11|
|purine-containing compound metabolic process|9.06|GPAT4,ACACA,TKT,RPE,ATP5MG,PGLS,NDUFB11|
|nucleobase-containing small molecule metabolic process|8.25|GPAT4,ACACA,TKT,RPE,ATP5MG,PGLS,RFK,NDUFB11|
|carbohydrate derivative metabolic process|6.64|GPAT4,HK2,ACACA,GPI,TKT,PFKP,RPE,ATP5MG,PGLS,RFK,NDUFB11|
</modal>