====== RO-3307 4.7μM R02 exp80 ======
==== Mechanism of Action ====
Inhibits CDK1, ATP-competitive, causes G2/M arrest
  * **<color #00a2e8>Class / Subclass 1:</color>** Cell Cycle / Kinase Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%(5Z)-5-(Quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 872573-93-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/135400873|135400873]]
    * **<color #00a2e8>IUPAC:</color>** %%(5Z)-5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylimino)-1,3-thiazolidin-4-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
    * **<color #00a2e8>INCHI Key:</color>** XOLMRFUGOINFDQ-YBEGLDIGSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 351.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC2=C(C=CC(=C2)C=C3C(=O)NC(=NCC4=CC=CS4)S3)N=C1
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC2=C(C=CC(=C2)/C=C\\3/C(=O)NC(=NCC4=CC=CS4)S3)N=C1
    * **<color #00a2e8>Molecular Formula:</color>** C18H13N3OS2
{{:chemogenomics:structures:chem-0056.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Tocris Bioscience
    * **<color #00a2e8>Catalog #:</color>** 4181
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C18H13N3OS2 352.05728; found 352.05802
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** RO-3306
    * **<color #00a2e8>Min:</color>** -12.5148; **<color #00a2e8>Max:</color>** 79.2860
{{:chemogenomics:dose_response:dr_23.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |4.5355    |
| IC30  |4.7770    |
| IC40  |4.9845    |
| IC50  |5.1828    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 02
    * **<color #00a2e8>Dose</color>**: 4.7µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.7
    * **<color #00a2e8>Numbers of reads</color>**: 11335426


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/73|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/RO_3306_4.7uM_Round-2_exp80.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='RO-3307 4.7μM R02 exp80'>
{{:chemogenomics:cranks_plots:exp80.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FAM122A|FAM122A]]|-2.87|0.04|
|[[:human_genes:C:CDK1|CDK1]]|-2.86|0.42|
|[[:human_genes:I:IVL|IVL]]|-2.80|0.16|
|[[:human_genes:T:TSC1|TSC1]]|-2.57|0.14|
|[[:human_genes:C:COPZ1|COPZ1]]|-2.38|0.35|
|[[:human_genes:C:CDC73|CDC73]]|-2.33|0.42|
|[[:human_genes:T:TCF4|TCF4]]|-2.21|0.35|
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.19|0.37|
|[[:human_genes:E:ERICH2|ERICH2]]|-2.19|0.35|
|[[:human_genes:D:DDX3X|DDX3X]]|-2.17|0.35|
|[[:human_genes:P:PRMT7|PRMT7]]|-2.14|0.35|
|[[:human_genes:S:SRRM3|SRRM3]]|-2.14|0.35|
|[[:human_genes:N:NCAPG2|NCAPG2]]|-2.12|0.42|
|[[:human_genes:T:TSC2|TSC2]]|-2.11|0.35|
|[[:human_genes:P:PLS3|PLS3]]|-2.11|0.35|
|[[:human_genes:V:VPS25|VPS25]]|-2.11|0.73|
|[[:human_genes:M:MME|MME]]|-2.08|0.42|
|[[:human_genes:L:LAS1L|LAS1L]]|-2.07|0.73|
|[[:human_genes:U:UBE4A|UBE4A]]|-2.07|0.37|
|[[:human_genes:N:NAA50|NAA50]]|-2.06|0.37|
|[[:human_genes:T:TAF1|TAF1]]|-2.05|0.42|
|[[:human_genes:C:CCDC172|CCDC172]]|-2.04|0.42|
|[[:human_genes:Z:ZNF486|ZNF486]]|-2.03|0.42|
|[[:human_genes:Z:ZC3H14|ZC3H14]]|-2.03|0.42|
|[[:human_genes:R:RIPPLY1|RIPPLY1]]|-2.02|0.42|
|[[:human_genes:I:INTS9|INTS9]]|-2.01|0.42|
|[[:human_genes:P:POLD1|POLD1]]|-2.00|0.42|
|[[:human_genes:A:AZI2|AZI2]]|-1.99|0.42|
|[[:human_genes:D:DUSP16|DUSP16]]|-1.97|0.42|
|[[:human_genes:R:RPS13|RPS13]]|-1.95|0.53|
|[[:human_genes:G:GMPPB|GMPPB]]|2.86|0.04|
|[[:human_genes:P:PPP1CA|PPP1CA]]|2.88|<0.01|
|[[:human_genes:P:PPP6C|PPP6C]]|2.92|<0.01|
|[[:human_genes:D:DDX42|DDX42]]|2.98|0.00|
|[[:human_genes:E:ENY2|ENY2]]|2.99|<0.01|
|[[:human_genes:L:LCMT1|LCMT1]]|3.00|0.00|
|[[:human_genes:K:KCTD5|KCTD5]]|3.03|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|3.04|0.00|
|[[:human_genes:F:FOPNL|FOPNL]]|3.12|0.00|
|[[:human_genes:D:DIABLO|DIABLO]]|3.20|0.00|
|[[:human_genes:C:CEP128|CEP128]]|3.20|0.00|
|[[:human_genes:T:TFAP4|TFAP4]]|3.29|0.00|
|[[:human_genes:V:VDAC2|VDAC2]]|3.32|0.00|
|[[:human_genes:H:HCCS|HCCS]]|3.32|<0.01|
|[[:human_genes:C:CASP2|CASP2]]|3.33|0.00|
|[[:human_genes:C:CASP9|CASP9]]|3.43|0.00|
|[[:human_genes:M:MTOR|MTOR]]|3.46|0.00|
|[[:human_genes:U:UBP1|UBP1]]|3.58|0.00|
|[[:human_genes:P:PPP6R3|PPP6R3]]|3.65|0.00|
|[[:human_genes:A:APAF1|APAF1]]|3.70|0.00|
|[[:human_genes:C:CYB5R4|CYB5R4]]|3.82|0.00|
|[[:human_genes:M:MLST8|MLST8]]|3.86|0.00|
|[[:human_genes:K:KIAA0753|KIAA0753]]|3.92|0.00|
|[[:human_genes:C:C2CD3|C2CD3]]|4.06|0.00|
|[[:human_genes:P:PPP2R4|PPP2R4]]|4.07|0.00|
|[[:human_genes:M:MARCH5|MARCH5]]|4.34|0.00|
|[[:human_genes:P:PPME1|PPME1]]|4.99|0.00|
|[[:human_genes:T:TIPRL|TIPRL]]|5.04|0.00|
|[[:human_genes:B:BAK1|BAK1]]|5.94|0.00|
|[[:human_genes:C:CCNF|CCNF]]|6.32|0.00|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.132|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.099|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.093|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.09|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.076|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.074|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.073|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.071|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp59|UMK57 1μM R01 exp59]]|0.069|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.137|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.129|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|0.118|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.111|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.11|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.107|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.107|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.105|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.105|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.099|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|0.099|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.099|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.091|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.091|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.09|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.089|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.085|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.083|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.077|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.073|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.072|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.072|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.071|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.067|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.066|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|0.066|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.062|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.06|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.059|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.058|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.058|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.057|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.055|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.055|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.054|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.053|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.052|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|0.051|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|0.051|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.051|<button type="primary" size="small" modal="49">View</button>|
</modal>


<modal id="1" size="lg" title="RO-3307 4.7μM R02 exp80  vs  Tozasertib 0.1μM R07 exp414">
{{:chemogenomics:comparison_plots:exp414_vs_exp80.png?nolink |}}
</modal>

<modal id="2" size="lg" title="RO-3307 4.7μM R02 exp80  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp34_vs_exp80.png?nolink |}}
</modal>

<modal id="3" size="lg" title="RO-3307 4.7μM R02 exp80  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp531_vs_exp80.png?nolink |}}
</modal>

<modal id="4" size="lg" title="RO-3307 4.7μM R02 exp80  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp524_vs_exp80.png?nolink |}}
</modal>

<modal id="5" size="lg" title="RO-3307 4.7μM R02 exp80  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp443_vs_exp80.png?nolink |}}
</modal>

<modal id="6" size="lg" title="RO-3307 4.7μM R02 exp80  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp80.png?nolink |}}
</modal>

<modal id="7" size="lg" title="RO-3307 4.7μM R02 exp80  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp527_vs_exp80.png?nolink |}}
</modal>

<modal id="8" size="lg" title="RO-3307 4.7μM R02 exp80  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp80_vs_exp85.png?nolink |}}
</modal>

<modal id="9" size="lg" title="RO-3307 4.7μM R02 exp80  vs  UMK57 1μM R01 exp59">
{{:chemogenomics:comparison_plots:exp59_vs_exp80.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Benzoate 20000μM R08 exp456  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp456_vs_exp80.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Latrunculin-B 10μM R07 exp374  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp374_vs_exp80.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Cytochalasin-B 5μM R07 exp349  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp349_vs_exp80.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp3_vs_exp80.png?nolink |}}
</modal>

<modal id="14" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp2_vs_exp80.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp478_vs_exp80.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Pimelic-diphenylamide-106 5μM R00 exp28  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp28_vs_exp80.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Bleomycin 5μM R08 exp459  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp459_vs_exp80.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Mitomycin-C 0.06μM R08 exp503  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp503_vs_exp80.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Etoposide 0.3μM R05 exp199  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp199_vs_exp80.png?nolink |}}
</modal>

<modal id="20" size="lg" title="BVD-523 15μM R02 exp67  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp67_vs_exp80.png?nolink |}}
</modal>

<modal id="21" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp259_vs_exp80.png?nolink |}}
</modal>

<modal id="22" size="lg" title="MS023 7μM R03 exp135  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp135_vs_exp80.png?nolink |}}
</modal>

<modal id="23" size="lg" title="AICAR 240μM R05 exp211  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp211_vs_exp80.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp357_vs_exp80.png?nolink |}}
</modal>

<modal id="25" size="lg" title="GSK626616 14μM R08 exp485  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp485_vs_exp80.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp355_vs_exp80.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Etoposide 1μM R00 exp19  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp19_vs_exp80.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Olaparib 4μM R08 exp512  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp512_vs_exp80.png?nolink |}}
</modal>

<modal id="29" size="lg" title="CI-1040 9.5μM R08 exp472  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp472_vs_exp80.png?nolink |}}
</modal>

<modal id="30" size="lg" title="AICAR 240μM R03 exp116  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp116_vs_exp80.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp440_vs_exp80.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Milciclib 2μM R08 exp502  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp502_vs_exp80.png?nolink |}}
</modal>

<modal id="33" size="lg" title="Hippuristanol 0.12μM R08 exp489 no dilution day6  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp489_vs_exp80.png?nolink |}}
</modal>

<modal id="34" size="lg" title="Hippuristanol 0.12μM R08 exp488  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp488_vs_exp80.png?nolink |}}
</modal>

<modal id="35" size="lg" title="Mdivi-1 15μM R05 exp217  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp217_vs_exp80.png?nolink |}}
</modal>

<modal id="36" size="lg" title="Centrinone 0.5μM R07 exp343  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp343_vs_exp80.png?nolink |}}
</modal>

<modal id="37" size="lg" title="Quercetin 20μM R08 exp517  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp517_vs_exp80.png?nolink |}}
</modal>

<modal id="38" size="lg" title="MS023 2μM R03 exp134  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp134_vs_exp80.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Atovaquone 15μM R08 exp451  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp451_vs_exp80.png?nolink |}}
</modal>

<modal id="40" size="lg" title="PU-H71 1μM R08 exp515  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp515_vs_exp80.png?nolink |}}
</modal>

<modal id="41" size="lg" title="CR131-b 0.005μM R08 exp474  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp474_vs_exp80.png?nolink |}}
</modal>

<modal id="42" size="lg" title="Ethanol 0.01 R05 exp234  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp234_vs_exp80.png?nolink |}}
</modal>

<modal id="43" size="lg" title="CB-5083 0.4μM R08 exp468  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp468_vs_exp80.png?nolink |}}
</modal>

<modal id="44" size="lg" title="LY2090314 0.003μM R08 exp500 no dilution day6  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp500_vs_exp80.png?nolink |}}
</modal>

<modal id="45" size="lg" title="Artemisinin 50μM R08 exp450  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp450_vs_exp80.png?nolink |}}
</modal>

<modal id="46" size="lg" title="JQ1 0.8μM R08 exp435  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp435_vs_exp80.png?nolink |}}
</modal>

<modal id="47" size="lg" title="LY2090314 0.003μM R08 exp499  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp499_vs_exp80.png?nolink |}}
</modal>

<modal id="48" size="lg" title="BI-D1870 3.15μM R02 exp66  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp66_vs_exp80.png?nolink |}}
</modal>

<modal id="49" size="lg" title="MLN-4924 2μM R00 exp22  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp22_vs_exp80.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.80|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|331.68|APAF1,CASP9,DIABLO|
|TORC1 complex|221.12|MLST8,MTOR|
|porin activity|221.12|BAK1,VDAC2|
|regulation of phosphoprotein phosphatase activity|51.42|TIPRL,PTPA,PPP6R3,MTOR|
|regulation of phosphatase activity|38.79|TIPRL,PTPA,PPP6R3,MTOR|
|regulation of protein dephosphorylation|30.71|TIPRL,PTPA,PPP6R3,MTOR|
|positive regulation of cysteine-type endopeptidase activity|22.47|BAK1,APAF1,CASP9,CASP2,DIABLO|
|regulation of dephosphorylation|22.34|TIPRL,PTPA,PPP6R3,MTOR|
|positive regulation of endopeptidase activity|19.19|BAK1,APAF1,CASP9,CASP2,DIABLO|
|centriole|18.68|CCNF,C2CD3,KIAA0753,CEP128,CEP20|
|positive regulation of peptidase activity|17.49|BAK1,APAF1,CASP9,CASP2,DIABLO|
|intrinsic apoptotic signaling pathway|17.27|BAK1,APAF1,CASP9,CASP2,DIABLO|
|regulation of cysteine-type endopeptidase activity|14.78|BAK1,APAF1,CASP9,CASP2,DIABLO|
|apoptotic signaling pathway|10.77|BAK1,APAF1,CASP9,CASP2,VDAC2,DIABLO|
|positive regulation of hydrolase activity|9.23|BAK1,PTPA,APAF1,MTOR,CASP9,CASP2,DIABLO,PLAA|
|positive regulation of apoptotic process|9.10|BAK1,PTPA,APAF1,CASP9,CASP2,TFAP4,DIABLO,PPP1CA|
|positive regulation of programmed cell death|8.72|BAK1,PTPA,APAF1,CASP9,CASP2,TFAP4,DIABLO,PPP1CA|
|regulation of hydrolase activity|7.52|BAK1,TIPRL,PTPA,APAF1,PPP6R3,MTOR,CASP9,CASP2,DIABLO,PLAA|
</modal>