ADAMTS5
Gene Information
- Official Symbol: ADAMTS5
- Official Name: ADAM metallopeptidase with thrombospondin type 1 motif 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 11096
- UniProt: Q9UNA0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. {ECO:0000250|UniProtKB:Q9R001, ECO:0000269|PubMed:16133547, ECO:0000269|PubMed:18992360}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16699
- Expression level (log2 read counts): -3.02
ADAMTS5 Expression in NALM6 Cells: -3.02
