ALDOC
Gene Information
- Official Symbol: ALDOC
- Official Name: aldolase, fructose-bisphosphate C
- Aliases and Previous Symbols: N/A
- Entrez ID: 230
- UniProt: P09972
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Glycolytic |
GO Terms
| fructose-bisphosphate aldolase activity |
| fructose 1,6-bisphosphate metabolic process |
| fructose metabolic process |
| glucose catabolic process to pyruvate |
| NADH regeneration |
| canonical glycolysis |
| glycolytic process through glucose-6-phosphate |
| glycolytic process through fructose-6-phosphate |
| glucose catabolic process |
| NADH metabolic process |
| glycolytic process |
| ATP generation from ADP |
| gluconeogenesis |
| NAD metabolic process |
| hexose biosynthetic process |
| ADP metabolic process |
| hexose catabolic process |
| monosaccharide biosynthetic process |
| tertiary granule lumen |
| nucleoside diphosphate phosphorylation |
| nucleotide phosphorylation |
| purine ribonucleoside diphosphate metabolic process |
| purine nucleoside diphosphate metabolic process |
| monosaccharide catabolic process |
| ribonucleoside diphosphate metabolic process |
| pyruvate metabolic process |
| cytoskeletal protein binding |
| nucleoside diphosphate metabolic process |
| glucose metabolic process |
| secretory granule lumen |
| carbohydrate catabolic process |
| ficolin-1-rich granule lumen |
| carbohydrate biosynthetic process |
| hexose metabolic process |
| monosaccharide metabolic process |
| ATP metabolic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| cytoskeleton |
| purine-containing compound metabolic process |
| generation of precursor metabolites and energy |
| small molecule catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| carbohydrate metabolic process |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| monocarboxylic acid metabolic process |
| nucleobase-containing small molecule metabolic process |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| epithelial cell differentiation |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| leukocyte activation |
| oxidation-reduction process |
| oxoacid metabolic process |
| secretion by cell |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| epithelium development |
| secretion |
| phosphorylation |
| small molecule metabolic process |
| tissue development |
| organic substance catabolic process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SGC2096 2.6μM R03 exp153 | -2.24 |
| Olaparib 4μM R08 exp512 | -1.93 |
| Azithromycin 100μM R08 exp452 | 1.78 |
| Fas-L 44ng/ml R08 exp482 | 1.78 |
| Cadmium 60μM R08 exp462 | 2.47 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4022
- Expression level (log2 read counts): 4.53
Expression Distribution
ALDOC Expression in NALM6 Cells: 4.53
