ALKBH7
Gene Information
- Official Symbol: ALKBH7
- Official Name: alkB homolog 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 84266
- UniProt: Q9BT30
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:25122757}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8278
- Expression level (log2 read counts): 3.73
ALKBH7 Expression in NALM6 Cells: 3.73
