AP1G2
Gene Information
- Official Symbol: AP1G2
- Official Name: adaptor related protein complex 1 subunit gamma 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8906
- UniProt: O75843
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. [provided by RefSeq, Aug 2017].
- UniProt Summary: May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV). {ECO:0000269|PubMed:16867982, ECO:0000269|PubMed:17553870, ECO:0000269|PubMed:9733768}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4236
- Expression level (log2 read counts): 6.43
AP1G2 Expression in NALM6 Cells: 6.43
