BATF2
Gene Information
- Official Symbol: BATF2
- Official Name: basic leucine zipper ATF-like transcription factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 116071
- UniProt: Q8N1L9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter. {ECO:0000250, ECO:0000269|PubMed:20531301}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17185
- Expression level (log2 read counts): -2.31
BATF2 Expression in NALM6 Cells: -2.31
