BCAM
Gene Information
- Official Symbol: BCAM
- Official Name: basal cell adhesion molecule (Lutheran blood group)
- Aliases and Previous Symbols: N/A
- Entrez ID: 4059
- UniProt: P50895
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]. Sequence Note: This RefSeq record represents the LU*0010101 allele.
- UniProt Summary: Laminin alpha-5 receptor. May mediate intracellular signaling. {ECO:0000269|PubMed:9616226}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3986
- Expression level (log2 read counts): 2.55
BCAM Expression in NALM6 Cells: 2.55
