BCAR1
Gene Information
- Official Symbol: BCAR1
- Official Name: BCAR1 scaffold protein, Cas family member
- Aliases and Previous Symbols: N/A
- Entrez ID: 9564
- UniProt: P56945
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH3 2 |
| DUF3513 |
| Serine rich |
| SH3 1 |
GO Terms
| actin filament reorganization |
| hepatocyte growth factor receptor signaling pathway |
| cellular response to hepatocyte growth factor stimulus |
| response to hepatocyte growth factor |
| neurotrophin TRK receptor signaling pathway |
| neurotrophin signaling pathway |
| platelet-derived growth factor receptor signaling pathway |
| epidermal growth factor receptor signaling pathway |
| actin cytoskeleton reorganization |
| vascular endothelial growth factor receptor signaling pathway |
| ERBB signaling pathway |
| insulin receptor signaling pathway |
| ruffle |
| integrin-mediated signaling pathway |
| positive regulation of endothelial cell migration |
| B cell receptor signaling pathway |
| SH3 domain binding |
| positive regulation of epithelial cell migration |
| regulation of endothelial cell migration |
| cellular response to insulin stimulus |
| T cell receptor signaling pathway |
| lamellipodium |
| cell chemotaxis |
| actin cytoskeleton |
| regulation of epithelial cell migration |
| response to insulin |
| actin filament organization |
| cellular response to peptide hormone stimulus |
| antigen receptor-mediated signaling pathway |
| cellular response to peptide |
| response to peptide hormone |
| focal adhesion |
| regulation of cell growth |
| immune response-activating cell surface receptor signaling pathway |
| supramolecular fiber organization |
| protein kinase binding |
| response to peptide |
| immune response-regulating cell surface receptor signaling pathway |
| cell division |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| positive regulation of cell migration |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| positive regulation of cell motility |
| response to growth factor |
| positive regulation of cellular component movement |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| activation of immune response |
| cellular response to nitrogen compound |
| regulation of growth |
| enzyme linked receptor protein signaling pathway |
| regulation of cell migration |
| positive regulation of immune response |
| response to hormone |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cytoskeleton organization |
| positive regulation of immune system process |
| regulation of immune response |
| cellular response to endogenous stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to endogenous stimulus |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of multicellular organismal process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 120/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 8/28 |
| blood | 1/28 |
| bone | 2/26 |
| breast | 5/33 |
| central nervous system | 8/56 |
| cervix | 0/4 |
| colorectal | 2/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 6/16 |
| kidney | 5/21 |
| liver | 4/20 |
| lung | 12/75 |
| lymphocyte | 0/16 |
| ovary | 6/26 |
| pancreas | 12/24 |
| peripheral nervous system | 3/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 3/24 |
| soft tissue | 3/9 |
| thyroid | 1/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 7/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12130
- Expression level (log2 read counts): -2.01
Expression Distribution
BCAR1 Expression in NALM6 Cells: -2.01
