Pfam Domains GO Terms
| Bcl-2 |
| caspase binding |
| signal transduction in absence of ligand |
| extrinsic apoptotic signaling pathway in absence of ligand |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| extrinsic apoptotic signaling pathway |
| female gamete generation |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| intrinsic apoptotic signaling pathway |
| positive regulation of cysteine-type endopeptidase activity |
| mitochondrial outer membrane |
| positive regulation of endopeptidase activity |
| positive regulation of peptidase activity |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| nuclear membrane |
| regulation of cysteine-type endopeptidase activity |
| apoptotic signaling pathway |
| positive regulation of proteolysis |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| protein heterodimerization activity |
| spermatogenesis |
| male gamete generation |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| gamete generation |
| positive regulation of cell death |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| cellular response to DNA damage stimulus |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| multi-organism reproductive process |
| negative regulation of cell death |
| programmed cell death |
| cell death |
| mitochondrion |
| regulation of hydrolase activity |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution