BNIP3
Gene Information
- Official Symbol: BNIP3
- Official Name: BCL2 interacting protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 664
- UniProt: Q12983
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
Pfam Domains GO Terms
Pfam Domains
| BNIP3 |
GO Terms
| intrinsic apoptotic signaling pathway in response to hypoxia |
| negative regulation of mitochondrial membrane permeability involved in apoptotic process |
| cellular response to cobalt ion |
| cardiac muscle cell apoptotic process |
| striated muscle cell apoptotic process |
| mitochondrial protein catabolic process |
| granzyme-mediated apoptotic signaling pathway |
| negative regulation of mitochondrial fusion |
| muscle cell apoptotic process |
| negative regulation of mitochondrial membrane permeability |
| autophagic cell death |
| positive regulation of necrotic cell death |
| negative regulation of membrane permeability |
| regulation of aerobic respiration |
| regulation of mitochondrial fusion |
| response to cobalt ion |
| mitochondrial fragmentation involved in apoptotic process |
| positive regulation of mitochondrial calcium ion concentration |
| negative regulation of mitochondrial membrane potential |
| negative regulation of membrane potential |
| positive regulation of striated muscle cell apoptotic process |
| positive regulation of cardiac muscle cell apoptotic process |
| mitochondrial outer membrane permeabilization |
| positive regulation of mitochondrial fission |
| positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| mitochondrial outer membrane permeabilization involved in programmed cell death |
| positive regulation of autophagy of mitochondrion |
| integral component of mitochondrial outer membrane |
| positive regulation of mitochondrial membrane permeability |
| response to hyperoxia |
| regulation of mitochondrial fission |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| positive regulation of membrane permeability |
| mitochondrial calcium ion homeostasis |
| positive regulation of muscle cell apoptotic process |
| brown fat cell differentiation |
| response to increased oxygen levels |
| regulation of necrotic cell death |
| positive regulation of release of cytochrome c from mitochondria |
| regulation of cellular respiration |
| GTPase binding |
| regulation of cardiac muscle cell apoptotic process |
| positive regulation of protein complex disassembly |
| mitochondrion disassembly |
| regulation of striated muscle cell apoptotic process |
| autophagy of mitochondrion |
| toxin transport |
| regulation of autophagy of mitochondrion |
| neuron apoptotic process |
| regulation of release of cytochrome c from mitochondria |
| neuron death |
| negative regulation of mitochondrion organization |
| negative regulation of reactive oxygen species metabolic process |
| apoptotic mitochondrial changes |
| organelle disassembly |
| positive regulation of macroautophagy |
| regulation of muscle cell apoptotic process |
| oligodendrocyte differentiation |
| cellular response to hydrogen peroxide |
| regulation of mitochondrial membrane potential |
| regulation of mitochondrial membrane permeability |
| cellular response to mechanical stimulus |
| regulation of membrane permeability |
| mitochondrial membrane |
| fat cell differentiation |
| reactive oxygen species metabolic process |
| regulation of protein complex disassembly |
| positive regulation of mitochondrion organization |
| cerebral cortex development |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| positive regulation of autophagy |
| mitochondrial membrane organization |
| cellular response to reactive oxygen species |
| intrinsic apoptotic signaling pathway |
| regulation of generation of precursor metabolites and energy |
| mitochondrial outer membrane |
| glial cell differentiation |
| regulation of macroautophagy |
| pallium development |
| positive regulation of apoptotic signaling pathway |
| regulation of reactive oxygen species metabolic process |
| nuclear envelope |
| regulation of mitochondrion organization |
| cellular response to hypoxia |
| cellular response to metal ion |
| defense response to virus |
| response to reactive oxygen species |
| cellular response to decreased oxygen levels |
| response to mechanical stimulus |
| cellular response to toxic substance |
| gliogenesis |
| cellular response to oxygen levels |
| mitochondrial transport |
| cellular response to inorganic substance |
| cellular response to oxidative stress |
| postsynaptic density |
| telencephalon development |
| autophagy |
| process utilizing autophagic mechanism |
| response to virus |
| apoptotic signaling pathway |
| response to antibiotic |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| regulation of autophagy |
| cellular response to external stimulus |
| response to hypoxia |
| response to decreased oxygen levels |
| positive regulation of cellular catabolic process |
| response to metal ion |
| negative regulation of organelle organization |
| response to oxygen levels |
| forebrain development |
| response to oxidative stress |
| regulation of apoptotic signaling pathway |
| cellular component disassembly |
| cellular response to drug |
| dendrite |
| regulation of membrane potential |
| positive regulation of catabolic process |
| cellular calcium ion homeostasis |
| mitochondrion organization |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| response to toxic substance |
| response to inorganic substance |
| cellular metal ion homeostasis |
| cellular protein catabolic process |
| positive regulation of organelle organization |
| metal ion homeostasis |
| cellular cation homeostasis |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| protein catabolic process |
| response to bacterium |
| positive regulation of cell death |
| viral process |
| negative regulation of cellular component organization |
| cation homeostasis |
| inorganic ion homeostasis |
| brain development |
| cellular chemical homeostasis |
| head development |
| symbiotic process |
| ion homeostasis |
| interspecies interaction between organisms |
| regulation of cellular catabolic process |
| membrane organization |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| cellular homeostasis |
| cellular macromolecule catabolic process |
| negative regulation of programmed cell death |
| apoptotic process |
| negative regulation of developmental process |
| defense response to other organism |
| central nervous system development |
| negative regulation of cell death |
| regulation of catabolic process |
| endoplasmic reticulum |
| response to drug |
| macromolecule catabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| immune effector process |
| cell death |
| chemical homeostasis |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| positive regulation of developmental process |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| neurogenesis |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3408
- Expression level (log2 read counts): 5.62
Expression Distribution
BNIP3 Expression in NALM6 Cells: 5.62
