BRK1
Gene Information
- Official Symbol: BRK1
- Official Name: BRICK1 subunit of SCAR/WAVE actin nucleating complex
- Aliases and Previous Symbols: N/A
- Entrez ID: 55845
- UniProt: Q8WUW1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q91VR8, ECO:0000269|PubMed:18560548}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| positive regulation of Arp2/3 complex-mediated actin nucleation |
| SCAR complex |
| positive regulation of actin nucleation |
| regulation of Arp2/3 complex-mediated actin nucleation |
| positive regulation of lamellipodium assembly |
| Rac protein signal transduction |
| regulation of actin nucleation |
| positive regulation of lamellipodium organization |
| regulation of lamellipodium assembly |
| protein homotrimerization |
| regulation of lamellipodium organization |
| Rac GTPase binding |
| protein trimerization |
| vascular endothelial growth factor receptor signaling pathway |
| positive regulation of actin filament polymerization |
| positive regulation of plasma membrane bounded cell projection assembly |
| positive regulation of protein polymerization |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| protein-containing complex binding |
| small GTPase mediated signal transduction |
| phagocytosis |
| protein homooligomerization |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| regulation of cellular component size |
| in utero embryonic development |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| immune response-regulating cell surface receptor signaling pathway |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| regulation of cellular component biogenesis |
| embryo development |
| identical protein binding |
| cell motility |
| localization of cell |
| immune effector process |
| cytoskeleton organization |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of cell population proliferation |
| regulation of immune system process |
| intracellular signal transduction |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| SNS-032 15μM R08 exp443 | -1.88 |
| GSK343 3μM R03 exp124 | -1.85 |
| LB-100 4.1μM R02 exp72 | 1.86 |
| Docetaxel 0.002μM R01 exp45 | 1.95 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 24/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 6/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 3/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 1/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17864
- Expression level (log2 read counts): 6.18
Expression Distribution
BRK1 Expression in NALM6 Cells: 6.18
