UniProt Summary: Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. {ECO:0000269|PubMed:24530860, ECO:0000269|PubMed:25261981, ECO:0000269|PubMed:28545464}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
peroxisome
process utilizing autophagic mechanism
autophagy
regulation of autophagy
regulation of cellular catabolic process
regulation of catabolic process
mitochondrion
cellular catabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739