C10orf54
Gene Information
- Official Symbol: VSIR
- Official Name: V-set immunoregulatory receptor
- Aliases and Previous Symbols: N/A
- Entrez ID: 64115
- UniProt: Q9H7M9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). {ECO:0000250|UniProtKB:Q9D659, ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}.
Pfam Domains GO Terms
Pfam Domains
| V-set |
GO Terms
| positive regulation of collagen catabolic process |
| negative regulation of CD8-positive, alpha-beta T cell proliferation |
| regulation of collagen catabolic process |
| negative regulation of CD8-positive, alpha-beta T cell activation |
| regulation of CD8-positive, alpha-beta T cell proliferation |
| endopeptidase activator activity |
| negative regulation of CD4-positive, alpha-beta T cell proliferation |
| negative regulation of alpha-beta T cell proliferation |
| regulation of CD4-positive, alpha-beta T cell proliferation |
| positive regulation of regulatory T cell differentiation |
| negative regulation of interleukin-17 production |
| regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of interleukin-10 production |
| positive regulation of collagen metabolic process |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| regulation of interleukin-17 production |
| regulation of alpha-beta T cell proliferation |
| regulation of regulatory T cell differentiation |
| negative regulation of interferon-gamma production |
| negative regulation of alpha-beta T cell activation |
| regulation of collagen metabolic process |
| zymogen activation |
| regulation of interleukin-10 production |
| negative regulation of tumor necrosis factor production |
| negative regulation of T cell proliferation |
| regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| positive regulation of T cell differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| regulation of interferon-gamma production |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| regulation of T cell proliferation |
| protein processing |
| regulation of lymphocyte differentiation |
| positive regulation of endopeptidase activity |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| positive regulation of hemopoiesis |
| positive regulation of peptidase activity |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of leukocyte proliferation |
| protein maturation |
| positive regulation of cell-cell adhesion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cytokine production |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| enzyme binding |
| positive regulation of proteolysis |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| regulation of endopeptidase activity |
| positive regulation of catabolic process |
| negative regulation of immune system process |
| regulation of peptidase activity |
| regulation of hemopoiesis |
| positive regulation of cell migration |
| regulation of lymphocyte activation |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| regulation of leukocyte activation |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| regulation of cell migration |
| regulation of cell motility |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of catabolic process |
| identical protein binding |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| proteolysis |
| regulation of hydrolase activity |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of gene expression |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11504
- Expression level (log2 read counts): -0.91
Expression Distribution
C10ORF54 Expression in NALM6 Cells: -0.91
