C15orf43
Gene Information
- Official Symbol: TERB2
- Official Name: telomere repeat binding bouquet formation protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 145645
- UniProt: Q8NHR7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. {ECO:0000250|UniProtKB:Q9D494}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12838
- Expression level (log2 read counts): -0.33
C15ORF43 Expression in NALM6 Cells: -0.33
