CAPN2
Gene Information
- Official Symbol: CAPN2
- Official Name: calpain 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 824
- UniProt: P17655
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.
Pfam Domains GO Terms
Pfam Domains
| Calpain III |
| Peptidase C2 |
GO Terms
| positive regulation of phosphatidylcholine biosynthetic process |
| regulation of phosphatidylcholine biosynthetic process |
| positive regulation of phospholipid biosynthetic process |
| positive regulation of striated muscle cell apoptotic process |
| positive regulation of cardiac muscle cell apoptotic process |
| behavioral response to pain |
| protein autoprocessing |
| regulation of phospholipid biosynthetic process |
| calcium-dependent cysteine-type endopeptidase activity |
| perinuclear endoplasmic reticulum |
| pseudopodium |
| positive regulation of myoblast fusion |
| cellular response to interferon-beta |
| regulation of myoblast fusion |
| myoblast fusion |
| positive regulation of syncytium formation by plasma membrane fusion |
| positive regulation of muscle cell apoptotic process |
| response to interferon-beta |
| regulation of syncytium formation by plasma membrane fusion |
| cysteine-type peptidase activity |
| response to pain |
| positive regulation of myotube differentiation |
| cell-cell fusion |
| syncytium formation by plasma membrane fusion |
| regulation of cardiac muscle cell apoptotic process |
| syncytium formation |
| regulation of striated muscle cell apoptotic process |
| positive regulation of phospholipid metabolic process |
| cortical actin cytoskeleton |
| myotube differentiation |
| regulation of myotube differentiation |
| positive regulation of striated muscle cell differentiation |
| extracellular matrix disassembly |
| multicellular organismal response to stress |
| regulation of muscle cell apoptotic process |
| cellular response to amino acid stimulus |
| cytoskeletal protein binding |
| mitochondrial intermembrane space |
| positive regulation of lipid biosynthetic process |
| regulation of phospholipid metabolic process |
| positive regulation of muscle cell differentiation |
| positive regulation of neuron death |
| blastocyst development |
| regulation of striated muscle cell differentiation |
| chromatin |
| response to amino acid |
| response to hydrogen peroxide |
| regulation of interleukin-6 production |
| positive regulation of lipid metabolic process |
| regulation of muscle cell differentiation |
| protein processing |
| female pregnancy |
| cellular response to lipopolysaccharide |
| regulation of lipid biosynthetic process |
| cellular response to molecule of bacterial origin |
| response to reactive oxygen species |
| striated muscle cell differentiation |
| cellular response to acid chemical |
| multi-multicellular organism process |
| cellular response to biotic stimulus |
| protein maturation |
| membrane raft |
| muscle cell differentiation |
| lysosome |
| response to antibiotic |
| regulation of neuron death |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| extracellular matrix organization |
| response to hypoxia |
| response to acid chemical |
| enzyme binding |
| response to decreased oxygen levels |
| neuronal cell body |
| in utero embryonic development |
| response to oxygen levels |
| extracellular structure organization |
| response to oxidative stress |
| external side of plasma membrane |
| regulation of lipid metabolic process |
| cellular component disassembly |
| focal adhesion |
| dendrite |
| muscle structure development |
| protein heterodimerization activity |
| response to toxic substance |
| cellular response to lipid |
| response to inorganic substance |
| regulation of cytoskeleton organization |
| behavior |
| proteolysis involved in cellular protein catabolic process |
| cellular response to organonitrogen compound |
| cellular protein catabolic process |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| cellular response to nitrogen compound |
| protein catabolic process |
| response to bacterium |
| regulation of cytokine production |
| positive regulation of cell death |
| calcium ion binding |
| response to lipid |
| anatomical structure formation involved in morphogenesis |
| cellular macromolecule catabolic process |
| positive regulation of cell differentiation |
| embryo development |
| Golgi apparatus |
| multi-organism reproductive process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| response to drug |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| response to cytokine |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| proteolysis |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell death |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Docetaxel 0.002μM R01 exp45 | -1.71 |
| Pyridostatin 4μM R05 exp240 | 1.88 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7090
- Expression level (log2 read counts): 2.8
Expression Distribution
CAPN2 Expression in NALM6 Cells: 2.8
