CASP6
Gene Information
- Official Symbol: CASP6
- Official Name: caspase 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 839
- UniProt: P55212
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015].
- UniProt Summary: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 18809
- Expression level (log2 read counts): 4.56
CASP6 Expression in NALM6 Cells: 4.56
