CAV1
Gene Information
- Official Symbol: CAV1
- Official Name: caveolin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 857
- UniProt: Q03135
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010].
- UniProt Summary: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). {ECO:0000250|UniProtKB:P49817, ECO:0000269|PubMed:11751885, ECO:0000269|PubMed:17287217, ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:25893292}.
Pfam Domains GO Terms
Pfam Domains
| Caveolin |
GO Terms
| negative regulation of inward rectifier potassium channel activity |
| negative regulation of peptidyl-tyrosine autophosphorylation |
| inward rectifier potassium channel inhibitor activity |
| angiotensin-activated signaling pathway involved in heart process |
| positive regulation of gap junction assembly |
| nitric oxide homeostasis |
| receptor internalization involved in canonical Wnt signaling pathway |
| endocytosis involved in viral entry into host cell |
| receptor-mediated endocytosis of virus by host cell |
| protein localization to plasma membrane raft |
| positive regulation of cell adhesion molecule production |
| regulation of gap junction assembly |
| regulation of inward rectifier potassium channel activity |
| caveola assembly |
| negative regulation of pinocytosis |
| regulation of peptidyl-tyrosine autophosphorylation |
| regulation of cell adhesion molecule production |
| caveolin-mediated endocytosis |
| regulation of the force of heart contraction by chemical signal |
| mammary gland involution |
| plasma membrane raft assembly |
| cellular response to hyperoxia |
| G protein-coupled receptor signaling pathway involved in heart process |
| regulation of entry of bacterium into host cell |
| negative regulation of nitric-oxide synthase activity |
| positive regulation of ER-associated ubiquitin-dependent protein catabolic process |
| positive regulation of toll-like receptor 3 signaling pathway |
| protein localization to basolateral plasma membrane |
| protein localization to membrane raft |
| regulation of cardiac muscle cell action potential involved in regulation of contraction |
| regulation of membrane repolarization during action potential |
| patched binding |
| plasma membrane raft organization |
| regulation of cell communication by electrical coupling involved in cardiac conduction |
| regulation of ER-associated ubiquitin-dependent protein catabolic process |
| angiotensin-activated signaling pathway |
| regulation of toll-like receptor 3 signaling pathway |
| peptidase activator activity |
| gas homeostasis |
| regulation of pinocytosis |
| negative regulation of monooxygenase activity |
| membrane raft assembly |
| regulation of cell communication by electrical coupling |
| negative regulation of necroptotic process |
| negative regulation of tyrosine phosphorylation of STAT protein |
| negative regulation of voltage-gated potassium channel activity |
| negative regulation of protein autophosphorylation |
| negative regulation of programmed necrotic cell death |
| nitric-oxide synthase binding |
| cellular response to increased oxygen levels |
| negative regulation of nitric oxide metabolic process |
| negative regulation of nitric oxide biosynthetic process |
| regulation of ventricular cardiac muscle cell action potential |
| positive regulation of ERAD pathway |
| negative regulation of necrotic cell death |
| negative regulation of anoikis |
| cellular response to exogenous dsRNA |
| regulation of necroptotic process |
| acrosomal membrane |
| negative regulation of potassium ion transmembrane transporter activity |
| regulation of programmed necrotic cell death |
| negative regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of receptor signaling pathway via STAT |
| membrane raft organization |
| cellular response to angiotensin |
| beta-catenin destruction complex disassembly |
| response to hyperoxia |
| cellular response to dsRNA |
| positive regulation of toll-like receptor signaling pathway |
| negative regulation of potassium ion transmembrane transport |
| negative regulation of oxidoreductase activity |
| regulation of anoikis |
| response to angiotensin |
| negative regulation of peptidyl-serine phosphorylation |
| inactivation of MAPK activity |
| regulation of the force of heart contraction |
| negative regulation of reactive oxygen species biosynthetic process |
| response to increased oxygen levels |
| regulation of cardiac muscle cell action potential |
| regulation of ERAD pathway |
| negative regulation of protein tyrosine kinase activity |
| lipid storage |
| regulation of necrotic cell death |
| regulation of ruffle assembly |
| positive regulation of vasoconstriction |
| vasoconstriction |
| negative regulation of potassium ion transport |
| positive regulation of cell junction assembly |
| regulation of membrane repolarization |
| membrane assembly |
| negative regulation of endothelial cell proliferation |
| positive regulation of response to endoplasmic reticulum stress |
| regulation of heart rate by cardiac conduction |
| regulation of cardiac muscle cell contraction |
| negative regulation of blood vessel diameter |
| membrane biogenesis |
| negative regulation of epithelial cell differentiation |
| regulation of actin filament-based movement |
| negative regulation of cation channel activity |
| mammary gland morphogenesis |
| negative regulation of endocytosis |
| regulation of nitric-oxide synthase activity |
| response to exogenous dsRNA |
| lactation |
| response to progesterone |
| regulation of protein autophosphorylation |
| molecular adaptor activity |
| cholesterol binding |
| response to ischemia |
| regulation of action potential |
| positive regulation of extrinsic apoptotic signaling pathway |
| negative regulation of peptidyl-tyrosine phosphorylation |
| membrane depolarization |
| response to dsRNA |
| negative regulation of reactive oxygen species metabolic process |
| T cell costimulation |
| regulation of monooxygenase activity |
| positive regulation of calcium ion transport into cytosol |
| Rac GTPase binding |
| cholesterol transport |
| lymphocyte costimulation |
| regulation of potassium ion transmembrane transporter activity |
| regulation of nitric oxide biosynthetic process |
| transport of virus |
| regulation of vasoconstriction |
| positive regulation of intrinsic apoptotic signaling pathway |
| regulation of smooth muscle contraction |
| negative regulation of cytokine-mediated signaling pathway |
| receptor internalization |
| negative regulation of response to cytokine stimulus |
| sterol transport |
| vasculogenesis |
| regulation of toll-like receptor signaling pathway |
| regulation of cardiac conduction |
| endocytic vesicle membrane |
| positive regulation of blood circulation |
| multi-organism localization |
| multi-organism transport |
| negative regulation of ion transmembrane transporter activity |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| body fluid secretion |
| negative regulation of protein ubiquitination |
| negative regulation of MAP kinase activity |
| triglyceride metabolic process |
| maintenance of protein location in cell |
| caveola |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| response to estrogen |
| regulation of cardiac muscle contraction |
| regulation of blood coagulation |
| regulation of tyrosine phosphorylation of STAT protein |
| negative regulation of transporter activity |
| cholesterol homeostasis |
| protein binding, bridging |
| regulation of hemostasis |
| regulation of potassium ion transmembrane transport |
| sterol homeostasis |
| ATPase binding |
| lipid droplet |
| regulation of coagulation |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| negative regulation of cation transmembrane transport |
| regulation of response to endoplasmic reticulum stress |
| negative regulation of protein modification by small protein conjugation or removal |
| regulation of reactive oxygen species biosynthetic process |
| regulation of fatty acid metabolic process |
| regulation of cell junction assembly |
| regulation of protein tyrosine kinase activity |
| canonical Wnt signaling pathway |
| regulation of striated muscle contraction |
| plasma membrane organization |
| cardiac conduction |
| positive regulation of protein binding |
| viral entry into host cell |
| regulation of potassium ion transport |
| negative regulation of ion transmembrane transport |
| regulation of oxidoreductase activity |
| maintenance of location in cell |
| regulation of heart rate |
| positive regulation of ubiquitin-dependent protein catabolic process |
| positive regulation of cold-induced thermogenesis |
| acylglycerol metabolic process |
| regulation of calcium ion transport into cytosol |
| gland morphogenesis |
| sarcolemma |
| heart process |
| neutral lipid metabolic process |
| tissue remodeling |
| negative regulation of protein binding |
| entry into host |
| entry into host cell |
| positive regulation of proteasomal protein catabolic process |
| receptor metabolic process |
| positive regulation of peptidyl-serine phosphorylation |
| maintenance of protein location |
| regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| positive regulation of protein ubiquitination |
| negative regulation of transmembrane transport |
| positive regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of calcium ion transport |
| regulation of proteasomal ubiquitin-dependent protein catabolic process |
| skeletal muscle tissue development |
| negative regulation of epithelial cell proliferation |
| ion channel binding |
| mammary gland development |
| regulation of endothelial cell proliferation |
| regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of protein serine/threonine kinase activity |
| skeletal muscle organ development |
| lipid homeostasis |
| regulation of receptor signaling pathway via STAT |
| positive regulation of protein modification by small protein conjugation or removal |
| multicellular organismal signaling |
| cell cortex |
| regulation of peptidyl-serine phosphorylation |
| regulation of wound healing |
| organic hydroxy compound transport |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| positive regulation of cellular protein catabolic process |
| regulation of epithelial cell differentiation |
| positive regulation of canonical Wnt signaling pathway |
| regulation of cold-induced thermogenesis |
| negative regulation of ion transport |
| negative regulation of cellular response to growth factor stimulus |
| response to calcium ion |
| early endosome membrane |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of ubiquitin-dependent protein catabolic process |
| regulation of extrinsic apoptotic signaling pathway |
| cellular response to transforming growth factor beta stimulus |
| interaction with host |
| regulation of muscle contraction |
| regulation of intrinsic apoptotic signaling pathway |
| response to transforming growth factor beta |
| regulation of cytokine-mediated signaling pathway |
| maintenance of location |
| regulation of response to wounding |
| negative regulation of MAPK cascade |
| vascular process in circulatory system |
| negative regulation of binding |
| regulation of cation channel activity |
| regulation of cellular ketone metabolic process |
| negative regulation of canonical Wnt signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of Wnt signaling pathway |
| positive regulation of binding |
| regulation of reactive oxygen species metabolic process |
| regulation of proteasomal protein catabolic process |
| positive regulation of peptidase activity |
| structural molecule activity |
| response to ketone |
| cilium |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of protein ubiquitination |
| viral life cycle |
| regulation of cell projection assembly |
| positive regulation of T cell activation |
| regulation of endocytosis |
| negative regulation of Wnt signaling pathway |
| cellular response to oxygen levels |
| regulation of proteolysis involved in cellular protein catabolic process |
| positive regulation of protein catabolic process |
| positive regulation of leukocyte cell-cell adhesion |
| regulation of protein binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| negative regulation of protein kinase activity |
| membrane raft |
| protein localization to cell periphery |
| regulation of protein modification by small protein conjugation or removal |
| regulation of muscle system process |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| receptor-mediated endocytosis |
| protein-containing complex disassembly |
| regulation of heart contraction |
| negative regulation of kinase activity |
| regulation of calcium ion transport |
| regulation of cellular protein catabolic process |
| calcium ion transport |
| cytoplasmic vesicle |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| regulation of ion transmembrane transporter activity |
| positive regulation of DNA-binding transcription factor activity |
| regulation of transmembrane transporter activity |
| protein-containing complex binding |
| cellular response to peptide hormone stimulus |
| endosome |
| regulation of cellular response to growth factor stimulus |
| positive regulation of ion transport |
| negative regulation of transferase activity |
| regulation of transporter activity |
| regulation of canonical Wnt signaling pathway |
| positive regulation of cytosolic calcium ion concentration |
| striated muscle tissue development |
| apoptotic signaling pathway |
| regulation of blood circulation |
| muscle organ development |
| divalent metal ion transport |
| muscle tissue development |
| regulation of leukocyte cell-cell adhesion |
| lipid transport |
| vesicle organization |
| divalent inorganic cation transport |
| regulation of T cell activation |
| angiogenesis |
| lipid localization |
| cellular response to peptide |
| response to steroid hormone |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| regulation of epithelial cell proliferation |
| signaling receptor binding |
| protein homooligomerization |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| response to hypoxia |
| enzyme binding |
| regulation of neurotransmitter levels |
| Wnt signaling pathway |
| response to decreased oxygen levels |
| positive regulation of proteolysis |
| cell-cell signaling by wnt |
| positive regulation of lymphocyte activation |
| regulation of Wnt signaling pathway |
| positive regulation of response to biotic stimulus |
| positive regulation of cellular catabolic process |
| response to metal ion |
| regulation of binding |
| leukocyte migration |
| glycerolipid metabolic process |
| response to oxygen levels |
| regulation of protein catabolic process |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| blood circulation |
| response to peptide hormone |
| circulatory system process |
| regulation of lipid metabolic process |
| regulation of apoptotic signaling pathway |
| regulation of cell-cell adhesion |
| cellular component disassembly |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| gland development |
| focal adhesion |
| positive regulation of cell activation |
| endomembrane system organization |
| regulation of DNA-binding transcription factor activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of small molecule metabolic process |
| regulation of membrane potential |
| positive regulation of catabolic process |
| cellular calcium ion homeostasis |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| calcium ion homeostasis |
| regulation of innate immune response |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| response to peptide |
| positive regulation of defense response |
| muscle structure development |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| negative regulation of transport |
| blood vessel development |
| protein heterodimerization activity |
| divalent inorganic cation homeostasis |
| regulation of body fluid levels |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| vasculature development |
| regulation of anatomical structure size |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| regulation of response to biotic stimulus |
| positive regulation of cell motility |
| posttranscriptional regulation of gene expression |
| response to growth factor |
| response to inorganic substance |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| endocytosis |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| regulation of system process |
| negative regulation of protein modification process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| Golgi membrane |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| regulation of cell activation |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| tube morphogenesis |
| cellular response to nitrogen compound |
| import into cell |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| viral process |
| negative regulation of cellular component organization |
| cation homeostasis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| regulation of defense response |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| symbiotic process |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| cation transport |
| regulation of cellular catabolic process |
| tube development |
| regulation of cell migration |
| response to lipid |
| membrane organization |
| negative regulation of transcription by RNA polymerase II |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| response to organic cyclic compound |
| apoptotic process |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| Golgi apparatus |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of catabolic process |
| negative regulation of cell death |
| response to organonitrogen compound |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| cell death |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| negative regulation of cellular macromolecule biosynthetic process |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
| system process |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18402
- Expression level (log2 read counts): -2.47
Expression Distribution
CAV1 Expression in NALM6 Cells: -2.47
