CCNB1IP1
Gene Information
- Official Symbol: CCNB1IP1
- Official Name: cyclin B1 interacting protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 57820
- UniProt: Q9NPC3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269|PubMed:12612082, ECO:0000269|PubMed:17297447}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17840
- Expression level (log2 read counts): 5.68
CCNB1IP1 Expression in NALM6 Cells: 5.68
