Entrez Summary: This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
MGC-24
GO Terms
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
endosome membrane
lysosome
cytoplasmic vesicle
cell-cell adhesion via plasma-membrane adhesion molecules
endosome
negative regulation of cell adhesion
muscle organ development
lysosomal membrane
muscle structure development
cell-cell adhesion
hemopoiesis
hematopoietic or lymphoid organ development
immune system development
negative regulation of cell population proliferation
regulation of cell adhesion
cell adhesion
biological adhesion
integral component of plasma membrane
regulation of cell population proliferation
immune response
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739