CD300A
Gene Information
- Official Symbol: CD300A
- Official Name: CD300a molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 11314
- UniProt: Q9UGN4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}.
Pfam Domains GO Terms
Pfam Domains
| V-set |
GO Terms
| negative regulation of activation of Janus kinase activity |
| negative regulation of phagocytosis, engulfment |
| negative regulation of NK T cell activation |
| negative regulation of membrane invagination |
| negative regulation of MyD88-dependent toll-like receptor signaling pathway |
| negative regulation of eosinophil activation |
| negative regulation of eosinophil migration |
| regulation of MyD88-dependent toll-like receptor signaling pathway |
| regulation of eosinophil activation |
| regulation of eosinophil migration |
| negative regulation of neutrophil activation |
| negative regulation of mast cell degranulation |
| negative regulation of B cell receptor signaling pathway |
| regulation of activation of Janus kinase activity |
| negative regulation of mast cell activation involved in immune response |
| regulation of NK T cell activation |
| regulation of neutrophil activation |
| negative regulation of myeloid leukocyte mediated immunity |
| phosphatidylethanolamine binding |
| negative regulation of leukocyte degranulation |
| negative regulation of mast cell activation |
| regulation of phagocytosis, engulfment |
| negative regulation of B cell proliferation |
| regulation of membrane invagination |
| negative regulation of phagocytosis |
| positive regulation of phosphoprotein phosphatase activity |
| negative regulation of regulated secretory pathway |
| regulation of B cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| negative regulation of fibroblast proliferation |
| negative regulation of B cell activation |
| positive regulation of phosphatase activity |
| regulation of mast cell degranulation |
| negative regulation of exocytosis |
| regulation of mast cell activation involved in immune response |
| negative regulation of alpha-beta T cell activation |
| regulation of T cell receptor signaling pathway |
| negative regulation of toll-like receptor signaling pathway |
| negative regulation of endocytosis |
| positive regulation of protein dephosphorylation |
| regulation of mast cell activation |
| negative regulation of leukocyte migration |
| regulation of leukocyte degranulation |
| negative regulation of leukocyte mediated immunity |
| negative regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of dephosphorylation |
| regulation of myeloid leukocyte mediated immunity |
| phosphatidylserine binding |
| negative regulation of intracellular transport |
| ficolin-1-rich granule membrane |
| regulation of B cell proliferation |
| regulation of antigen receptor-mediated signaling pathway |
| regulation of toll-like receptor signaling pathway |
| tertiary granule membrane |
| negative regulation of lymphocyte proliferation |
| negative regulation of MAP kinase activity |
| negative regulation of mononuclear cell proliferation |
| negative regulation of leukocyte proliferation |
| regulation of fibroblast proliferation |
| regulation of alpha-beta T cell activation |
| regulation of phagocytosis |
| negative regulation of T cell activation |
| regulation of phosphoprotein phosphatase activity |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of receptor signaling pathway via JAK-STAT |
| negative regulation of protein serine/threonine kinase activity |
| regulation of receptor signaling pathway via STAT |
| regulation of protein dephosphorylation |
| negative regulation of lymphocyte activation |
| negative regulation of immune response |
| regulation of regulated secretory pathway |
| negative regulation of MAPK cascade |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| regulation of phosphatase activity |
| regulation of leukocyte migration |
| negative regulation of cell activation |
| negative regulation of secretion by cell |
| signaling receptor activity |
| regulation of endocytosis |
| regulation of leukocyte mediated immunity |
| regulation of B cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of dephosphorylation |
| positive regulation of immune effector process |
| regulation of leukocyte proliferation |
| regulation of exocytosis |
| negative regulation of protein kinase activity |
| negative regulation of secretion |
| negative regulation of kinase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of cell migration |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| regulation of leukocyte cell-cell adhesion |
| negative regulation of cellular component movement |
| regulation of T cell activation |
| negative regulation of locomotion |
| regulation of MAP kinase activity |
| regulation of intracellular transport |
| regulation of cell-cell adhesion |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of innate immune response |
| regulation of immune effector process |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| regulation of response to biotic stimulus |
| myeloid cell activation involved in immune response |
| regulation of vesicle-mediated transport |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| regulation of leukocyte activation |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| regulation of cellular localization |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.504 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4659
- Expression level (log2 read counts): -4.6
Expression Distribution
CD300A Expression in NALM6 Cells: -4.6
