CD80
Gene Information
- Official Symbol: CD80
- Official Name: CD80 molecule
- Aliases and Previous Symbols: N/A
- Entrez ID: 941
- UniProt: P33681
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. {ECO:0000269|PubMed:10583602}.
Pfam Domains GO Terms
Pfam Domains
| C2-set 2 |
| V-set |
GO Terms
| positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process |
| protein complex involved in cell adhesion |
| regulation of granulocyte macrophage colony-stimulating factor biosynthetic process |
| positive regulation of T-helper 1 cell differentiation |
| regulation of T-helper 1 cell differentiation |
| positive regulation of granulocyte macrophage colony-stimulating factor production |
| positive regulation of interleukin-2 biosynthetic process |
| regulation of granulocyte macrophage colony-stimulating factor production |
| regulation of interleukin-2 biosynthetic process |
| positive regulation of T-helper 1 type immune response |
| positive regulation of T-helper cell differentiation |
| regulation of T-helper 1 type immune response |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of interleukin-2 production |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| regulation of T-helper cell differentiation |
| coreceptor activity |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| T cell costimulation |
| regulation of interleukin-2 production |
| lymphocyte costimulation |
| regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of alpha-beta T cell activation |
| negative regulation of T cell proliferation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of cytokine biosynthetic process |
| negative regulation of lymphocyte proliferation |
| negative regulation of mononuclear cell proliferation |
| virus receptor activity |
| negative regulation of leukocyte proliferation |
| positive regulation of T cell differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| viral entry into host cell |
| positive regulation of T cell proliferation |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| entry into host |
| entry into host cell |
| regulation of cytokine biosynthetic process |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| positive regulation of lymphocyte proliferation |
| positive regulation of mononuclear cell proliferation |
| positive regulation of leukocyte proliferation |
| regulation of T cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| regulation of T cell proliferation |
| interaction with host |
| regulation of adaptive immune response |
| positive regulation of protein kinase B signaling |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| cellular response to lipopolysaccharide |
| positive regulation of hemopoiesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| cellular response to molecule of bacterial origin |
| negative regulation of cell activation |
| viral life cycle |
| positive regulation of T cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| cellular response to biotic stimulus |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of protein kinase B signaling |
| regulation of leukocyte proliferation |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| regulation of leukocyte cell-cell adhesion |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| positive regulation of lymphocyte activation |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of cell activation |
| negative regulation of immune system process |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of immune effector process |
| regulation of lymphocyte activation |
| cellular response to lipid |
| regulation of leukocyte activation |
| cell surface |
| regulation of cell activation |
| cytokine-mediated signaling pathway |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| viral process |
| symbiotic process |
| interspecies interaction between organisms |
| response to lipid |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| positive regulation of cell differentiation |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| positive regulation of developmental process |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13195
- Expression level (log2 read counts): -4.27
Expression Distribution
CD80 Expression in NALM6 Cells: -4.27
