CHRNB4
Gene Information
- Official Symbol: CHRNB4
- Official Name: cholinergic receptor nicotinic beta 4 subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 1143
- UniProt: P30926
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Pfam Domains GO Terms
Pfam Domains
| Neur chan LBD |
| Neur chan memb |
GO Terms
| synaptic transmission involved in micturition |
| positive regulation of transmission of nerve impulse |
| behavioral response to nicotine |
| micturition |
| cholinergic synapse |
| ligand-gated ion channel activity |
| acetylcholine receptor activity |
| acetylcholine-gated cation-selective channel activity |
| acetylcholine-gated channel complex |
| acetylcholine binding |
| regulation of transmission of nerve impulse |
| synaptic transmission, cholinergic |
| neuromuscular synaptic transmission |
| excretion |
| extracellular ligand-gated ion channel activity |
| response to nicotine |
| smooth muscle contraction |
| regulation of smooth muscle contraction |
| excitatory postsynaptic potential |
| positive regulation of nervous system process |
| chemical synaptic transmission, postsynaptic |
| tertiary granule membrane |
| specific granule membrane |
| action potential |
| regulation of postsynaptic membrane potential |
| regulation of neurotransmitter secretion |
| protein heterooligomerization |
| renal system process |
| regulation of nervous system process |
| regulation of neurotransmitter transport |
| adult behavior |
| regulation of muscle contraction |
| locomotory behavior |
| postsynaptic membrane |
| regulation of muscle system process |
| muscle contraction |
| synapse |
| muscle system process |
| neuron projection |
| regulation of neurotransmitter levels |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| neutrophil degranulation |
| protein heterodimerization activity |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| response to toxic substance |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| cell junction |
| behavior |
| myeloid leukocyte activation |
| regulation of system process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulated exocytosis |
| regulation of secretion by cell |
| leukocyte mediated immunity |
| exocytosis |
| regulation of secretion |
| regulation of cellular localization |
| leukocyte activation |
| ion transmembrane transport |
| secretion by cell |
| response to drug |
| export from cell |
| cell activation |
| immune effector process |
| cell-cell signaling |
| secretion |
| transmembrane transport |
| ion transport |
| nervous system process |
| integral component of plasma membrane |
| protein-containing complex assembly |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10484
- Expression level (log2 read counts): 2.49
Expression Distribution
CHRNB4 Expression in NALM6 Cells: 2.49
