CLIP3
Gene Information
- Official Symbol: CLIP3
- Official Name: CAP-Gly domain containing linker protein 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 25999
- UniProt: Q96DZ5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}.
Pfam Domains GO Terms
Pfam Domains
| CAP GLY |
| Ank 2 |
GO Terms
| ganglioside binding |
| chaperone-mediated protein transport |
| negative regulation of microtubule polymerization |
| peptidyl-L-cysteine S-palmitoylation |
| peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine |
| protein palmitoylation |
| Golgi stack |
| negative regulation of microtubule polymerization or depolymerization |
| peptidyl-cysteine modification |
| membrane biogenesis |
| positive regulation of glucose transmembrane transport |
| regulation of microtubule polymerization |
| positive regulation of protein localization to plasma membrane |
| regulation of tumor necrosis factor-mediated signaling pathway |
| positive regulation of protein localization to cell periphery |
| negative regulation of protein polymerization |
| regulation of glucose transmembrane transport |
| regulation of microtubule polymerization or depolymerization |
| recycling endosome membrane |
| protein lipidation |
| lipoprotein biosynthetic process |
| trans-Golgi network membrane |
| regulation of protein localization to plasma membrane |
| positive regulation of endocytosis |
| fat cell differentiation |
| regulation of protein localization to cell periphery |
| lipoprotein metabolic process |
| positive regulation of protein localization to membrane |
| negative regulation of supramolecular fiber organization |
| negative regulation of protein complex assembly |
| negative regulation of cytoskeleton organization |
| early endosome membrane |
| regulation of cytokine-mediated signaling pathway |
| trans-Golgi network |
| regulation of response to cytokine stimulus |
| protein acylation |
| regulation of microtubule cytoskeleton organization |
| regulation of protein localization to membrane |
| positive regulation of transmembrane transport |
| regulation of endocytosis |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| membrane raft |
| microtubule binding |
| positive regulation of cellular protein localization |
| regulation of supramolecular fiber organization |
| negative regulation of organelle organization |
| regulation of protein complex assembly |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| regulation of transmembrane transport |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| peptidyl-amino acid modification |
| regulation of cellular localization |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of organelle organization |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| protein transport |
| peptide transport |
| regulation of apoptotic process |
| regulation of programmed cell death |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| regulation of cell death |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7172
- Expression level (log2 read counts): 1.92
Expression Distribution
CLIP3 Expression in NALM6 Cells: 1.92
