CNGA3
Gene Information
- Official Symbol: CNGA3
- Official Name: cyclic nucleotide gated channel subunit alpha 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 1261
- UniProt: Q16281
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
- UniProt Summary: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5978
- Expression level (log2 read counts): -0.67
CNGA3 Expression in NALM6 Cells: -0.67
