COPRS
Gene Information
- Official Symbol: COPRS
- Official Name: coordinator of PRMT5 and differentiation stimulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 55352
- UniProt: Q9NQ92
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10897
- Expression level (log2 read counts): 4.33
COPRS Expression in NALM6 Cells: 4.33
