CPA4
Gene Information
- Official Symbol: CPA4
- Official Name: carboxypeptidase A4
- Aliases and Previous Symbols: N/A
- Entrez ID: 51200
- UniProt: Q9UI42
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. [provided by RefSeq, Jul 2008].
- UniProt Summary: Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). {ECO:0000269|PubMed:10383164, ECO:0000269|PubMed:20385563}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8983
- Expression level (log2 read counts): 1.4
CPA4 Expression in NALM6 Cells: 1.4
