CSNK1G1
Gene Information
- Official Symbol: CSNK1G1
- Official Name: casein kinase 1 gamma 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 53944
- UniProt: Q9HCP0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016].
- UniProt Summary: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269|PubMed:21680713}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17066
- Expression level (log2 read counts): 5.81
CSNK1G1 Expression in NALM6 Cells: 5.81
