UniProt Summary: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). {ECO:0000250}.
Pfam DomainsGO Terms
Pfam Domains
Pkinase
CK1gamma C
Pkinase Tyr
GO Terms
peptidyl-threonine phosphorylation
peptidyl-threonine modification
positive regulation of canonical Wnt signaling pathway
peptidyl-serine phosphorylation
positive regulation of Wnt signaling pathway
peptidyl-serine modification
protein kinase activity
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
protein serine/threonine kinase activity
cell surface receptor signaling pathway involved in cell-cell signaling
endocytosis
import into cell
peptidyl-amino acid modification
protein phosphorylation
cell-cell signaling
phosphorylation
ATP binding
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)