CXCL11
Gene Information
- Official Symbol: CXCL11
- Official Name: C-X-C motif chemokine ligand 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 6373
- UniProt: O14625
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Pfam Domains GO Terms
Pfam Domains
| IL8 |
GO Terms
| CXCR3 chemokine receptor binding |
| T cell chemotaxis |
| T cell migration |
| positive regulation of release of sequestered calcium ion into cytosol |
| lymphocyte chemotaxis |
| chemokine activity |
| positive regulation of calcium ion transport into cytosol |
| antimicrobial humoral immune response mediated by antimicrobial peptide |
| lymphocyte migration |
| positive regulation of calcium ion transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| chemokine-mediated signaling pathway |
| cell |
| neutrophil chemotaxis |
| granulocyte chemotaxis |
| response to chemokine |
| cellular response to chemokine |
| neutrophil migration |
| regulation of calcium ion transport into cytosol |
| granulocyte migration |
| antimicrobial humoral response |
| positive regulation of calcium ion transport |
| regulation of sequestering of calcium ion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| myeloid leukocyte migration |
| positive regulation of cation transmembrane transport |
| leukocyte chemotaxis |
| cAMP-mediated signaling |
| regulation of calcium ion transmembrane transport |
| positive regulation of ion transmembrane transport |
| heparin binding |
| cyclic-nucleotide-mediated signaling |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| positive regulation of transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| cell chemotaxis |
| cellular response to biotic stimulus |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of calcium ion transport |
| positive regulation of ion transport |
| positive regulation of cytosolic calcium ion concentration |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| regulation of cytosolic calcium ion concentration |
| regulation of cation transmembrane transport |
| second-messenger-mediated signaling |
| humoral immune response |
| leukocyte migration |
| regulation of metal ion transport |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| divalent inorganic cation homeostasis |
| inflammatory response |
| cellular response to lipid |
| chemotaxis |
| taxis |
| cellular metal ion homeostasis |
| regulation of transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulation of ion transport |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| ion homeostasis |
| response to lipid |
| cellular homeostasis |
| regulation of cellular localization |
| cell migration |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| cellular response to oxygen-containing compound |
| cell motility |
| localization of cell |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| extracellular space |
| regulation of cell population proliferation |
| homeostatic process |
| intracellular signal transduction |
| regulation of transport |
| immune response |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17149
- Expression level (log2 read counts): -6.6
Expression Distribution
CXCL11 Expression in NALM6 Cells: -6.6
