DCAF6
Gene Information
- Official Symbol: DCAF6
- Official Name: DDB1 and CUL4 associated factor 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 55827
- UniProt: Q58WW2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].
- UniProt Summary: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:16964240}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13060
- Expression level (log2 read counts): 4.96
DCAF6 Expression in NALM6 Cells: 4.96
