DCLRE1C
Gene Information
- Official Symbol: DCLRE1C
- Official Name: DNA cross-link repair 1C
- Aliases and Previous Symbols: N/A
- Entrez ID: 64421
- UniProt: Q96SD1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
- UniProt Summary: N/A
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8862
- Expression level (log2 read counts): 5.81
DCLRE1C Expression in NALM6 Cells: 5.81
