UniProt Summary: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Pfam DomainsGO Terms
Pfam Domains
Cadherin C
Cadherin
GO Terms
desmosome
cornified envelope
cornification
homophilic cell adhesion via plasma membrane adhesion molecules
cell-cell junction
keratinization
cell-cell adhesion via plasma-membrane adhesion molecules
keratinocyte differentiation
epidermal cell differentiation
skin development
epidermis development
cell-cell adhesion
epithelial cell differentiation
calcium ion binding
cell adhesion
biological adhesion
programmed cell death
cell death
epithelium development
tissue development
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739