EIF4EBP1
Gene Information
- Official Symbol: EIF4EBP1
- Official Name: eukaryotic translation initiation factor 4E binding protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1978
- UniProt: Q13541
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| eIF 4EBP |
GO Terms
| cap-independent translational initiation of linear mRNA |
| cap-independent translational initiation |
| IRES-dependent translational initiation of linear mRNA |
| eukaryotic initiation factor 4E binding |
| translation repressor activity |
| postsynaptic cytosol |
| negative regulation of translational initiation |
| TOR signaling |
| cellular response to dexamethasone stimulus |
| cytoplasmic translational initiation |
| protein phosphatase 2A binding |
| response to dexamethasone |
| response to amino acid starvation |
| response to ischemia |
| cellular response to glucocorticoid stimulus |
| cellular response to corticosteroid stimulus |
| cytoplasmic translation |
| regulation of translational initiation |
| insulin receptor signaling pathway |
| cellular response to ketone |
| response to antineoplastic agent |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| response to ethanol |
| negative regulation of translation |
| negative regulation of protein complex assembly |
| translational initiation |
| response to glucocorticoid |
| negative regulation of cellular amide metabolic process |
| positive regulation of mitotic cell cycle |
| response to corticosteroid |
| cellular response to insulin stimulus |
| lung development |
| respiratory tube development |
| cellular response to xenobiotic stimulus |
| cellular response to hypoxia |
| cellular response to steroid hormone stimulus |
| response to ketone |
| response to starvation |
| respiratory system development |
| cellular response to decreased oxygen levels |
| cellular response to oxygen levels |
| response to insulin |
| response to alcohol |
| cellular response to peptide hormone stimulus |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| response to xenobiotic stimulus |
| response to antibiotic |
| cellular response to peptide |
| response to steroid hormone |
| response to hypoxia |
| glutamatergic synapse |
| regulation of translation |
| response to decreased oxygen levels |
| positive regulation of cell cycle |
| response to oxygen levels |
| translation |
| response to peptide hormone |
| regulation of cellular amide metabolic process |
| cellular response to drug |
| peptide biosynthetic process |
| regulation of protein complex assembly |
| response to peptide |
| response to nutrient levels |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cellular response to lipid |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| response to extracellular stimulus |
| cellular response to organic cyclic compound |
| protein-containing complex |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| cellular response to nitrogen compound |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| enzyme linked receptor protein signaling pathway |
| cellular amide metabolic process |
| tube development |
| response to lipid |
| response to hormone |
| response to organic cyclic compound |
| regulation of cellular component biogenesis |
| cell cycle process |
| response to organonitrogen compound |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| response to abiotic stimulus |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 2μM R07 exp306 | 1.79 |
| INK128 0.2μM R02 exp70 | 2.3 |
| Torin1 0.08μM R02 exp82 | 3.51 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7682
- Expression level (log2 read counts): 5.26
Expression Distribution
EIF4EBP1 Expression in NALM6 Cells: 5.26
