EIF4EBP2
Gene Information
- Official Symbol: EIF4EBP2
- Official Name: eukaryotic translation initiation factor 4E binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 1979
- UniProt: Q13542
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| eIF 4EBP |
GO Terms
| eukaryotic initiation factor 4E binding |
| translation repressor activity |
| negative regulation of translational initiation |
| TOR signaling |
| intraspecies interaction between organisms |
| social behavior |
| multi-organism behavior |
| regulation of translational initiation |
| postsynapse |
| insulin receptor signaling pathway |
| memory |
| negative regulation of translation |
| cAMP-mediated signaling |
| negative regulation of cellular amide metabolic process |
| cellular response to insulin stimulus |
| cyclic-nucleotide-mediated signaling |
| regulation of synaptic plasticity |
| response to insulin |
| learning or memory |
| cellular response to peptide hormone stimulus |
| cognition |
| cellular response to peptide |
| second-messenger-mediated signaling |
| regulation of translation |
| translation |
| response to peptide hormone |
| regulation of cellular amide metabolic process |
| peptide biosynthetic process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| response to peptide |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| posttranscriptional regulation of gene expression |
| amide biosynthetic process |
| peptide metabolic process |
| behavior |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| enzyme linked receptor protein signaling pathway |
| cellular amide metabolic process |
| response to hormone |
| response to organonitrogen compound |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| cellular response to endogenous stimulus |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| cellular nitrogen compound biosynthetic process |
| intracellular signal transduction |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| macromolecule biosynthetic process |
| system process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6306
- Expression level (log2 read counts): 7.62
Expression Distribution
EIF4EBP2 Expression in NALM6 Cells: 7.62
