UniProt Summary: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Pfam DomainsGO Terms
Pfam Domains
Lactamase B 2
Lactamase B
GO Terms
3-tRNA processing endoribonuclease activity
endonucleolytic cleavage involved in tRNA processing
tRNA 3-trailer cleavage, endonucleolytic
tRNA 3-trailer cleavage
tRNA 3-end processing
ncRNA 3-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA 3-end processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ncRNA processing
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739