UniProt Summary: Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. {ECO:0000269|PubMed:17452337}.
Pfam DomainsGO Terms
Pfam Domains
ELMO CED12
GO Terms
GTPase activator activity
positive regulation of GTPase activity
regulation of GTPase activity
positive regulation of hydrolase activity
regulation of hydrolase activity
positive regulation of catalytic activity
positive regulation of molecular function
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739